Pathology (not already covered in Pathoma) Flashcards by Robbie Gruhl | Brainscape

Q

Presentation of tubulointerstitial nephritis

A

polyuria, nocturia

metabolic acidosis

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Q

Tubulointerstial Nephritis

key histological finding

A

massive proliferation of interstial tissue

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Q

Chronic Pyelonephritis

gross pathology changes

A

papillary necrosis at tips of papillae

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Q

Chronic Pyelonephritis

etiology

A

usually:

vesicoureteral reflux

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Q

Pyonephritis

complication from

A

chronic pyelonephritis

loss of renal parenchyma

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Q

Thryroidization of kidney seen in

A

chronic pyelonephritis

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Q

Chronic Pyelonephritis

presentation

A

usually silent

possibly recurrent acute pyelo

HTN and renal insufficiency

focal segmental glomerulosclerosis

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Q

Gross pathology

irregular, scarred surface of kidneys

if bilateral: asymmetrical

A

chonic pyelonephritis findings

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Q

Urate and Ca²⁺

tubulointerstiail diseases

A

like small stones, just in tubules

not in ureters

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Q

Urate Nephropathy

most common etiology

A

tumor lysis syndrome

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Q

Urate Nephropathy

type of

A

tubulointerstitial nephropathy

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Q

Bence-Jones proteins origninate form

A

multiple myeloma

monoclonal light chains

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Q

Bence-Jones proteinuria

damages

A

directly toxic to tubles

and

forms casts

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Q

Perinephric abcess

A

possible complication of chronic pyelo

may need to be drained with nephrostomy tubes

sometimes Abx just can’t get there enough to work

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Q

Acute Tubular Necrosis

1˚ etiology

A

hypoperfusion

shock, hypovolemia

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Q

2 etiologies of acute tubular necrosis

A

ischemia

nephrotoxic agents

esp. aminoglycoside Abx

Q

Eosinophilia in

A

acute interstitial nephritis

Q

Kimmelstiel-Wilson nodules

seen in

A

diabetic nephropathy

Q

Membranous Nephropathy

autoantigen

A

anti-phospholipase A2

Q

Membranous Nephropathy

basic pathology

A

chronic antigen-antibody mediated disease

anti-phospholipase A2

Q

Renal tumor

large and yellow on gross

A

renal cell carcinoma

Q

Renal Cell Carcinoma

assiciation

A

VHL

Von-Hippel Lindau disease

Q

Renal Cell Carcinoma

mutation

A

VHL

Von-Hippel Lindau

congenital or aquired

almost all acquired renal cell carcinomas have VHL mutation

if congenital VHL mutation, then Von-Hippel Lindau disease

Q

VHL chromosome

A

3p