Urinary Malignancy

Question 1

Risk factors of RCC

Answer 1

Smoking • ESRD • Obesity
• Urban living exposure
• Factory workers • Trichloroethylene exposure
• HTN
• Radiation • Survivor of Wilm’s tumor m in Pediatric
• Family history of RCC
altersurvival

Question 2

Type of cell in RCC derived from

Answer 2

• Clear cell ( Proximal convoluted tubule )
• Papillary ( Proximal convoluted tubule )
• Chromophobe ( intercalated cells of Collecting Duct )
• Collecting duct ( Collecting Duct )

Question 3

Answer 3

Clear Cell : round cells with abundant cytoplasm

Question 4

Answer 4

Papillary : Type1 basophilic cell and Type2 eosinophilic cell

Question 5

Answer 5

Chromophobe : thick cell wall with peri-nuclear halo

Question 6

Answer 6

Collecting duct : cobblestone appearance

Question 7

Von Hippel-Lindau Syndrome , Familial syndrome of RCC , VHL tumor…. Gene ?

Answer 7

Tumor suppressor gene

Question 8

VHL …. Cell RCC

Answer 8

Clear cell

Question 9

Manifestations of VHL

Answer 9

Question 10

Hereditary papillary RCC (HPRCC)

Answer 10

Papillary RCC
Least common familial syndrome
Less aggressive
Bilateral and multi focal
No extra renal manifestations

Question 11

Familial leiomyomatosis (HLRCC)

Answer 11

Question 12

Birt-Hogg-Dube Syndrome

Answer 12

Question 13

Clincal presentation of RCC

Answer 13

50% are incidental
Flank Pain if distention Mass
Hematuria
Palpable mass
Right side Varicocele uncommonunless
Lower limb edema
thereis other-pathology

Question 14

Work up of RCC

Answer 14

Question 15

Ttt RC

Answer 15

Question 16

Epidemiology of bladder urethral cancer

Answer 16

Median age 70 years
4th most common cancer after prostate, lung and cancer
9th most common cancer among women
More common in Caucasian men

Question 17

Risk factors of bladder urethleial cancer

Answer 17

Question 18

Presentation of bladder cancer

Answer 18

Question 19

Work up bladder cancer

Answer 19

Question 20

Staging of bladder cancer

Answer 20

Question 21

Risk factors of prostate cancer

Answer 21

Family history : risk is increased when the relative is closer and when the number of affected relatives is higher.

African descent

Advanced age > 65 year

Question 22

Work up of prostate cancer

Answer 22

Question 23

Ttt of prostate can so

Answer 23