Urinary Malignancy Flashcards
Risk factors of RCC
Smoking • ESRD • Obesity
• Urban living exposure
• Factory workers • Trichloroethylene exposure
• HTN
• Radiation • Survivor of Wilm’s tumor m in Pediatric
• Family history of RCC
altersurvival
Type of cell in RCC derived from
- Clear cell ( Proximal convoluted tubule )
- Papillary ( Proximal convoluted tubule )
- Chromophobe ( intercalated cells of Collecting Duct )
- Collecting duct ( Collecting Duct )
Clear Cell : round cells with abundant cytoplasm
Papillary : Type1 basophilic cell and Type2 eosinophilic cell
Chromophobe : thick cell wall with peri-nuclear halo
Collecting duct : cobblestone appearance
Von Hippel-Lindau Syndrome , Familial syndrome of RCC , VHL tumor…. Gene ?
Tumor suppressor gene
VHL …. Cell RCC
Clear cell
Manifestations of VHL
Hereditary papillary RCC (HPRCC)
Papillary RCC
Least common familial syndrome
Less aggressive
Bilateral and multi focal
No extra renal manifestations
Familial leiomyomatosis (HLRCC)
Birt-Hogg-Dube Syndrome
Clincal presentation of RCC
50% are incidental
Flank Pain if distention Mass
Hematuria
Palpable mass
Right side Varicocele uncommonunless
Lower limb edema
thereis other-pathology
Work up of RCC
Ttt RC
Epidemiology of bladder urethral cancer
Median age 70 years
4th most common cancer after prostate, lung and cancer
9th most common cancer among women
More common in Caucasian men
Risk factors of bladder urethleial cancer
Presentation of bladder cancer
Work up bladder cancer
Staging of bladder cancer
Risk factors of prostate cancer
Family history : risk is increased when the relative is closer and when the number of affected relatives is higher.
African descent
Advanced age > 65 year
Work up of prostate cancer
Ttt of prostate can so
