Urinary Drugs Flashcards
Anticholinergic Drugs
Darifenacin, oxybutynin, Solifenacin, Trospium
Which anticholinergic is M3 selective
Darifenacin
Darifenacin, oxybutynin, solifenacin Tox
Peripheral: dry mouth, mydriasis, constipation, urinary retention, tachycardia; Central: sedation, confusion, hallucinations, slowed cognitive fxn, sleep disruption
Trospium Tox
Peripheral: dry mouth, mydriasis, constipation, urinary retention, tachycardia; LEAST likely to prod central effects b/c Quaternary
Darifenacin PK
2D6 + 3A4; 13-19 hr half-life; poor oral bioavailability
oxybutynin PK
3A4; 2 hr half-life; poor oral bioavailability; give extended release
Solifenacin PK
3A4; 45-68 hr half-life; 90% bioavailability
Trospium PK
No CYP metabolism; 12-20 hr half-life; poor oral bioavailability (take on empty stomach)
Mirabegron MOA
Beta-3 Agonist; increases bladder capacity by relaxing detrussor smooth muscle
Mirabegron Tox
Increases BP- monitoring recommended esp in HTN pts; tachycardia
MIrabegron PK
3A4»_space; 2D6; also butylcholinesterase, UGT, & alcohol dehydrogenase; 50 hr half-life; oral bioavailability dec by food
Neostigmine MOA
Inhibits Ach-Esterase; augments action of Ach at both muscarinic & nicotinic receptors
Neostigmine Tox
AV Block, Bradyarrhythmias, Cardiac arrest, Cardiac dysrhythmia, Hypotension, Syncope, Tachycardia
Neostigmine PK
Inactivated by cholinesterases & hepatic microsomal enzymes; half-life < 1 hr; poor oral bioavailability
Which drug is used for treatment of urinary retention
Neostigmine
AE of anticholinergics
urinary retention, CV (palpitations, tachycardia, prolonged QTc interval), GI (constipation)
CI of anticholinergics
angle closure or narrow-angle glaucoma
urinary and gastric obstruction
need for mental alertness
Alzheimer’s type dementia
