Urinary Drugs Flashcards
Anticholinergic Drugs
Darifenacin, oxybutynin, Solifenacin, Trospium
Which anticholinergic is M3 selective
Darifenacin
Darifenacin, oxybutynin, solifenacin Tox
Peripheral: dry mouth, mydriasis, constipation, urinary retention, tachycardia; Central: sedation, confusion, hallucinations, slowed cognitive fxn, sleep disruption
Trospium Tox
Peripheral: dry mouth, mydriasis, constipation, urinary retention, tachycardia; LEAST likely to prod central effects b/c Quaternary
Darifenacin PK
2D6 + 3A4; 13-19 hr half-life; poor oral bioavailability
oxybutynin PK
3A4; 2 hr half-life; poor oral bioavailability; give extended release
Solifenacin PK
3A4; 45-68 hr half-life; 90% bioavailability
Trospium PK
No CYP metabolism; 12-20 hr half-life; poor oral bioavailability (take on empty stomach)
Mirabegron MOA
Beta-3 Agonist; increases bladder capacity by relaxing detrussor smooth muscle
Mirabegron Tox
Increases BP- monitoring recommended esp in HTN pts; tachycardia
MIrabegron PK
3A4»_space; 2D6; also butylcholinesterase, UGT, & alcohol dehydrogenase; 50 hr half-life; oral bioavailability dec by food
Neostigmine MOA
Inhibits Ach-Esterase; augments action of Ach at both muscarinic & nicotinic receptors
Neostigmine Tox
AV Block, Bradyarrhythmias, Cardiac arrest, Cardiac dysrhythmia, Hypotension, Syncope, Tachycardia
Neostigmine PK
Inactivated by cholinesterases & hepatic microsomal enzymes; half-life < 1 hr; poor oral bioavailability
Which drug is used for treatment of urinary retention
Neostigmine
