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Repro Pharm > Prostate Drugs > Flashcards

Prostate Drugs Flashcards

1
Q

Alfuzosin MOA

A

Short-acting selective Alpha-1 Blocker

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2
Q

Alfuozosin Tox

A

GI-xerostomia, nausea; CNS- dizziness, somnolence, asthenia, h/a, insomnia

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3
Q

Alfuozosin M&E

A

CYP3A4; fecal/renal elim

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4
Q

Does alfuozosin need does titration?

A

No

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5
Q

Tadalafil MOA

A

PDE-5 Inhibitor: decreases breakdown of cGMP; Relief of BPH occurs via smooth muscle relaxation

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6
Q

Tadalafil Tox

A

Uncommon; h/a, nausea, indigestion, nasopharyngitis, URTI; more rare-NAION, retinal artery occlusion, hearing loss

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7
Q

Tadalafil M&E

A

CYP3A4; fecal elim

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8
Q

Tadalafil DDI

A

Nitrates-profound hypotension exacerbated by alcohol

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9
Q

Saw Palmetto?

A

useless shit drug

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10
Q

Androgen Receptor Blockers (3)

A

Bicalutamide, flutamide, nilutamide

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11
Q

Bicalutamide MOA

A

Androgen Receptor Blocker; Prostate > Central; Antagonist + some agonist activity

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12
Q

Bicalutamide Tox

A

GI tox, hot flashes, aches/pains

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13
Q

Flutamide MOA

A

Androgen Receptor Blocker; Prostate; Antagonist

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14
Q

Flutamide Tox

A

GI tox, hot flashes, aches/pains
AND
Blood Dyscrasia

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15
Q

Flutamide BBW

A

Hepatotoxicity/Failure

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16
Q

Nilutamide MOA

A

Androgen Receptor Blocker; prostate & central

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17
Q

Nilutamide Tox

A

GI tox, hot flashes, aches/pains
AND
HF/ HTN, Blood Dyscrasia; Increased time to accommodate transition from light to dark

18
Q

Nilutamide BBW

A

Respiratory insufficiency

19
Q

Estramustine MOA

A

Targeted Alkylator; Estradiol w/ Alkylating Moiety which is a MT inhibitor: promotes dis-assembly and G2/M arrest and produces DNA strand breakage

20
Q

Estramustine Tox

A

Common: GI upset, gynecomastia, mastalgia, and impotence;
Testosterone levels decreased via negative feedback on HPA;
Due to Estradiol: edema, thromboembolism, MI, PE, stroke;
Elevated hepatic enzymes, hyperbilirubinemia

21
Q

Estramustine Administration

A

Oral

22
Q

GnRH agonists

A

Goserelin, Histrelin, Leuprolide, Triptorelin

23
Q

Histrelin Tox

A

Unique=Seizures & Suicidal Ideation;

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

24
Q

Goserelin Tox

A

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

25
Q

Leuprolide Tox

A

Unique=MI/HF

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

26
Q

Triptorelin Tox

A

Edema, HTN, h/a, fatigue, depression, dec bone mineral density, spinal compression, elevated TG, weight gain, DM, reduced libido, sexual dysfxn, gynecomastia, rarely hepatotox, aches/pains

27
Q

Pregnancy Categories of GnRH agonists

A

Cat X

28
Q

Goserelin Admin

A

SC; Initial transient dz flare avoided by 2-4 wks of AR blockers

29
Q

Histrelin Admin

A

SC; Initial transient dz flare avoided by 2-4 wks of AR blockers

30
Q

Leuprolide Admin

A

IM/SC; Initial transient dz flare avoided by 2-4 wks of AR blockers

31
Q

Triptorelin Admin

A

IM; Initial transient dz flare avoided by 2-4 wks of AR blockers

32
Q

Degarelix MOA

A

GnRH Antagonist; Reduced LH & FSH secretion; castrate testosterone levels w/in 3 days (quicker than GnRH Agonists)

33
Q

Degarelix Tox

A

Hot sweats, injxn site rxns, weight gain, HTN, arthralgia, chills, fatigue, impotence, elevated hepatic enzyme levels (reversible), QT prolongation

34
Q

Degarelix Admin

A

SC; Avoids initial dz flare

35
Q

Abiraterone MOA

A

17-Alpha-Reductase Inhibitor

36
Q

Abiraterone Tox

A

Produce hypermineralocorticoid state: HTN, hypokalemia, and fluid retention, caution w/ pre-existing CV issues; elevated hepatic enzymes; routine LFT’s required

37
Q

Abiraterone Pregnancy Cat

A

Cat X: women cannot handle drug, condom should be used if partner is pregnant

38
Q

Adjuvant tx with abiraterone

A

Tx in combo w/ corticosteroid to avoid hypermineralocorticoid state

39
Q

Sipuleucel-T MOA

A

Individualized immunotherapy to stimulate T cell immunity against Prostatic Acid Phosphatase (PAP)

40
Q

Sipuleucel-T Tox

A

Mild infusion rxns; fever/chills/dyspnea; N/V; paresthesias, citrate tox, fatigue

Repro Pharm (7 decks)

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