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Repro Pharm > Ovarian/Bladder Cancer > Flashcards

Ovarian/Bladder Cancer Flashcards

1
Q

Carboplatin MOA

A

Forms DNA intrastrand crosslinks and adducts

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2
Q

Carboplatin Tox

A

Allergic platinum rxns; dose-related myelosuppression; cumulative anemia; dose-related N/V; Blood chemistry dyscrasia; elev hepatic enzymes, BUN/Cr

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3
Q

Carboplatin Use

A

Ovarian

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4
Q

Cisplatin MOA

A

Forms DNA intrastrand crosslinks and adducts

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5
Q

Cisplatin Tox

A

Allergic platinum rxns; dose-related severe nephrotox, myelosuppression, & N/V; significant ototox in children

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6
Q

Cisplatin Use

A

Ovarian + Bladder

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7
Q

Cyclophosphamide MOA

A

Pro-drug of active alkylating moiety

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8
Q

Cyclophosphamide Tox

A

Blood Dyscrasia: anemia/infxn; hemorrhagic cystitis (Mesna); N/V; rashes; amenorrhea/infertility; monitor for secondary malignancies; pulmonary fibrosis

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9
Q

Cyclophosphamide Use

A

Ovarian

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10
Q

Doxorubicin MOA

A

Intercalator, free radical generator, topo II inhibitor

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11
Q

Doxorubicin Tox

A

myelosuppression; CHF; hepatic dz; secondary malignancies; extravasational necrosis; N/V

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12
Q

Doxorubin Use

A

Ovarian + Bladder

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13
Q

Paclitaxel MOA

A

MT stabilizer inhibiting depolymerization

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14
Q

Paclitaxel Tox

A

Taxane hypersensitivity; myelosuppression; myalgia/arthralgia

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15
Q

Paclitaxel Use

A

Ovarian

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16
Q

BCG MOA

A

Binds to urothelial cells, activates APCs, induces prod of effector cells (CTL, NK, LAK, BAK)

17
Q

BCG Use

A

Bladder; 50 mL instillation held for 1-2 hr weekly x6

18
Q

Mitomycin C MOA

A

Mono- & bi-functional alkylating agent

19
Q

MItomycin C Tox

A

Pancytopenia (when IV); chemical cystitis; contact dermatitis but also as palmar and plantar erythemas if contact made w/ instillate solution or void volume

20
Q

Mytomycin C Use

21
Q

Thiotepa MOA

A

Polyfunctional alkylator with loss of aziridine (alkylator) moiety

22
Q

Thiotepa Tox

A

Pancytopenia (when IV); dysuria; urinary retention; chemical/hemorrhagic cystitis; renal dysfxn

23
Q

Thiotepa Use

Repro Pharm (7 decks)

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