urinary Flashcards
functions of the kidney (including specifics regarding homeostatic regulation of the blood):
CHIRFPE
controls bv
homeostatic regulation of blood composition
influences bp
releases erythropoietin ,increase RBC
filters blood
produces urine
excretion of wastes
How does kidney stabilize blood pH? (homeostatic regulation of blood composition , ions, fluid balance and blood ph)
controlling excretion of H+ hydrogen ions and CO3 bicarbonate ions in the urine
homeostatic regulation of blood composition includes
ions, fluid balance, blood ph
What major wastes does the kidney filter?
nitrogenous wastes (Urea/Uric Acid, Creatinine)
the blood test to measure their level, and the condition that results when they are high
The blood test is the blood urea nitrogen, BUN
When the BUN is high, it is called
Azotemia
the anatomy of the kidney (the structures, locations, and general functions).
cacop cocacap
Renal capsule surrounds the kidney.
Renal cortex is the outer area that contains nephrons. This is where most urine production occurs.
Renal Pyramids are conical structures in the renal medulla. They hold the collecting ducts that collect urine from nephrons and channel it down towards the renal papilla/minor calyx.
Renal columns are bands of cortical tissue that go between the pyramids out to the cortex. The columns provide a path for vessels to get out to the cortex.
minor calyx collects urine from the renal pyramid and funnels it towards the major calyx. Multiple minor calices merge to form the major calyx.
major calices merge to form the renal pelvis. renal pelvis is the large funnel shaped structure that funnels urine into the ureter.
flow of BLOOD through the kidney
renal artery
segmental artery
Interlobar artery
arcuate artery
interlobular artery
Then blood flows into the afferent glomerular arteriole
glomerulus
out of efferent glomerular arteriole
peritubular capillaries
venule
interlobular vein
arcuate vein
interlobar vein
renal vein
What type of capillaries make up glomerulus?
fenestrated capillaries
What type of cells surround glomerulus?
Podocytes
What vessels bring blood into and out of the glomerulus?
Afferent arteriole goes in and efferent arteriole goes out.
Which of the 2 vessels in glomerulus is smaller and why does that matter?
Efferent arteriole brings blood out of the glomerulus. It is smaller than the afferent. This makes it harder for blood to leave the glomerulus so there is increased pressure in the glomerulus (pushes out to drive filtration).
3 layers of the filtration membrane in the glomerulus
Endothelial cells, dense layer, podocytes
Which things pass through the filtration membrane of glomerulus and which things remain in the blood?
Small things like water, ions, amino acids, fatty acids, and glucose are pushed thorough from the blood into the capsular space. wigaf
Large things like plasma proteins and blood cells remain in the blood and do not enter the urine.
flow of FLUID through the kidney
Capsular space
PCT
nephron loop
DCT
Collecting duct
Papillary
Minor calyx
Major calyx
Renal pelvis
Ureter
Bladder
Urethra
cortical nephrons :
location
structure
function
Location: cortex
structure: short loop of henle / nephron loop
Materials reabsorbed enter peritubular capillaries
juxtamedullary nephrons:
Location
structure
Function
Location: medulla of the kidney
structure: long loop of henle / nephron loop
Materials reabsorbed enter the vasa recta
Function: allow the body to excrete concentrated urine. They allow for the reabsorption of more water so the water isn’t lost in the urine.
What is the primary function of the PCT?
and How is water reabsorbed?
REABSORPTION of nutrients, ions and water
diffusion
Describe the reabsorption that occurs in the LOH/nephron loop (include the different processes that occur in the descending limb versus the ascending limb and the permeability of each segment).
The LOH/nephron loop is for reabsorption of
Na+ Cl- and water.
Water , osmosis -descending limb
(impermeable to solutes & ions, ONLY WATER IS permeable)
Na/Cl, water -ascending limb via active transport.
is permeable to water and impermeable to solutes
descending limb
A major function of the DCT is
“selective reabsorption”
What does this “selective reabsorption” mean?
and what hormones act in this segment?
Reabsorption of ions or water occurs but ONLY if a particular hormone is present.
What hormones act in this segment? Calcitonin, Parathyroid Hormone (PTH), Aldosterone, Antidiuretic Hormone (ADH)… ADH really works in the collecting duct too.
What are the functions of those hormones in the selective reabsorption?
Calcitonin: Decreased reabsorption of calcium to promote the loss of calcium in the urine.
PTH: Increased reabsorption of calcium to recover calcium from the urine back into the body.
Aldosterone: Increased reabsorption of sodium (Na+) and excretion of potassium (K+).
ADH: Inserts aquaporins into the DCT and collecting duct to allow water to be reabsorbed from the urine. This decreases urine volume and allows us to conserve water.
hormones that Decreased reabsorption of calcium to promote the loss of calcium in the urine.
calcitonin