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I Can't Feel My Face > Uptown Funk > Flashcards

Uptown Funk Flashcards

1
Q

A complex network of macromolecules in the extracellular space is known as..

A

the extracellular matrix (ECM).

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2
Q

A complex network of macromolecules in the extracellular space is known as..

A

the extracellular matrix (ECM).

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3
Q

The ECM is secreted by..

A

the cells which inhabit it.

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4
Q

The ECM..

A) Volume
B) Function

A

A) Substantial part of tissue volume

B) Gives structural and organizational support to tissues

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5
Q

This protein makes up 30% of the total body proteins..

A

Collagen.

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6
Q

90% of Collagen protein in the body is Type..

A

Type I.

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7
Q

Collagen has this type of structure.. which is stabilized by..

A

Triple-helical structure.. crosslinks.

Characteristic repeating sequence: Gly-X-Y

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8
Q

Two types of collagen are..

A

Fibrillar (Type I) and nonfibrillar collagens (Type IV).

Note: different types and combos of collagen molecules predominate in different tissues.

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9
Q

The synthesis of collagen is dependent upon..

A

physiologic conditions such as diet or mechanical stress.

Note: collagen is frequently remodeled.

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10
Q

This condition results from a genetic mutation that causes the glycine in Type I collagen to be replaced by another amino acid..

A

Osteogenesis/dentogenesis imperfecta.

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11
Q

Osteognesis/dentinogenesis imperfecta result in a mutated Type I collagen, involving this amino acid..

A

glycine.

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12
Q

Elastin functions to..

A

provide flexibility and resilience to the ECM.

Note: found in tissues that require elasticity (skin, lungs, intestines).

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13
Q

This is the predominent ECM molecule in blood vessels..

A

Elastin.

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14
Q

Elastin is stabilized by..

A

two-way crosslinks.

Note: lysyl oxidase important enzyme in elastin crosslinking

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15
Q

This ECM molecule is not synthesized after adolescence..

A

Elastin.

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16
Q

This molecule facilitates communication between intracellular and extracellular compartments..

A

Fibronectin.

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17
Q

Fibronectin Binds..

A

to other ECM molecules and to other integrin molecules on cells.

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18
Q

Fibronectin is important for..

A

cell adhesion, growth, migration, and wound healing.

Note: loss of fibronectin from surface of tumor cells, may play a role in metastasis

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19
Q

This molecule is found primarily in the basal lamina..

A

Laminin.

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20
Q

Laminin functions to..

A

give structural support to the ECM.

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21
Q

This molecule acts as a major component of basement membranes in epithelial and muscle tissues..

A

Laminin.

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22
Q

Laminin beings to cells through this family of proteins..

A

integrins.

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23
Q

Diseases associated with abnormal laminin..

A

muscular dystrophies, epidermolysis bullosa (lethal skin blistering), defects of kidney filter.

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24
Q

These are the gel-formers of the ECM..

A

Proteoglycans.

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25
Q

The many negative charges of proteoglycans attract.. resultiing in..

A

attract cations and water, resulting in the hydration of the ECM (provides rigidity and durability).

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26
Q

Proteoglycans make up this percentage of the ECM..

A
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27
Q

Because of the hydrophilicity of proteoglycans, these fill up most of the extracellular space..

A

GAG chains.

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28
Q

Proteoglycans have several functions, including..

A

binding of growth factors, regulation of enzymatic activity, and acting as co-receptors.

29
Q

Lysosomal storage diseases..

A

leads to the build of macromolecules within the lysome, which eventually leads to cell death.

Note: caused by genetic defect in gene coding for lysosomal activity. Not in notes.

30
Q

ECM regulates 3 cellular processes..

A

proliferation, differentiation, migration.

31
Q

Four main families of molecules comprise the ECM..

A

Collagens, Elastins, Glycoproteins, and Proteoglycans.

32
Q

Goodpasture’s Syndrome is..

A

an autoimmune disease associated with anomalies in Type IV collagen.

33
Q

Alport Syndrome is associated with..

A

defective Type IV collagen chains.

34
Q

This cofactor is needed for the synthesis of collagen..

A

Vitamin C (ascorbic acid).

35
Q

Two glycoproteins are..

A

fibronectin and laminin.

36
Q

The ECM is secreted by..

A

the cells which inhabit it.

37
Q

The ECM..

A) Volume
B) Function

A

A) Substantial part of tissue volume

B) Gives structural and organizational support to tissues

38
Q

This protein makes up 30% of the total body proteins..

A

Collagen.

39
Q

90% of Collagen protein in the body is Type..

A

Type I.

40
Q

Collagen has this type of structure.. which is stabilized by..

A

Triple-helical structure.. crosslinks.

Characteristic repeating sequence: Gly-X-Y

41
Q

Two types of collagen are..

A

Fibrillar (Type I) and nonfibrillar collagens (Type IV).

Note: different types and combos of collagen molecules predominate in different tissues.

42
Q

The synthesis of collagen is dependent upon..

A

physiologic conditions such as diet or mechanical stress.

Note: collagen is frequently remodeled.

43
Q

This condition results from a genetic mutation that causes the glycine in Type I collagen to be replaced by another amino acid..

A

Osteogenesis/dentogenesis imperfecta.

44
Q

Osteognesis/dentinogenesis imperfecta result in a mutated Type I collagen, involving this amino acid..

A

glycine.

45
Q

Elastin functions to..

A

provide flexibility and resilience to the ECM.

Note: found in tissues that require elasticity (skin, lungs, intestines).

46
Q

This is the predominent ECM molecule in blood vessels..

A

Elastin.

47
Q

Elastin is stabilized by..

A

two-way crosslinks.

Note: lysyl oxidase important enzyme in elastin crosslinking

48
Q

This ECM molecule is not synthesized after adolescence..

A

Elastin.

49
Q

This molecule facilitates communication between intracellular and extracellular compartments..

A

Fibronectin.

50
Q

Fibronectin Binds..

A

to other ECM molecules and to other integrin molecules on cells.

51
Q

Fibronectin is important for..

A

cell adhesion, growth, migration, and wound healing.

Note: loss of fibronectin from surface of tumor cells, may play a role in metastasis

52
Q

This molecule is found primarily in the basal lamina..

A

Laminin.

53
Q

Laminin functions to..

A

give structural support to the ECM.

54
Q

This molecule acts as a major component of basement membranes in epithelial and muscle tissues..

A

Laminin.

55
Q

Laminin beings to cells through this family of proteins..

A

integrins.

56
Q

Diseases associated with abnormal laminin..

A

muscular dystrophies, epidermolysis bullosa (lethal skin blistering), defects of kidney filter.

57
Q

These are the gel-formers of the ECM..

A

Proteoglycans.

58
Q

The many negative charges of proteoglycans attract.. resultiing in..

A

attract cations and water, resulting in the hydration of the ECM (provides rigidity and durability).

59
Q

Proteoglycans make up this percentage of the ECM..

A

Less than ten percent.

60
Q

Because of the hydrophilicity of proteoglycans, these fill up most of the extracellular space..

A

GAG chains.

61
Q

Proteoglycans have several functions, including..

A

binding of growth factors, regulation of enzymatic activity, and acting as co-receptors.

62
Q

Lysosomal storage diseases..

A

leads to the build of macromolecules within the lysome, which eventually leads to cell death.

Note: caused by genetic defect in gene coding for lysosomal activity. Not in notes.

63
Q

ECM regulates 3 cellular processes..

A

proliferation, differentiation, migration.

64
Q

Four main families of molecules comprise the ECM..

A

Collagens, Elastins, Glycoproteins, and Proteoglycans.

65
Q

Goodpasture’s Syndrome is..

A

an autoimmune disease associated with anomalies in Type IV collagen.

66
Q

Alport Syndrome is associated with..

A

defective Type IV collagen chains.

67
Q

This cofactor is needed for the synthesis of collagen..

A

Vitamin C (ascorbic acid).

68
Q

Two glycoproteins are..

A

fibronectin and laminin.

I Can't Feel My Face (3 decks)

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