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Anesthesia Pharm > Uptake/Distribution of VA > Flashcards

Uptake/Distribution of VA Flashcards

1
Q

definition of MAC

A

Fe agent or alveolar concentration at which 50% of patients don’t move upon noxious stimuli

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2
Q

brain concentration of MAC

A

estimated by alveolar concentration or Et concentration

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3
Q

MAC awake

A

1/3 - 1/4 MAC

patient able to respond appropriately

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4
Q

MAC intubation

A

> > MAC

more stimulating than incision

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5
Q

MAC incision

A

= MAC

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6
Q

MAC BAR

A

30-40% > MAC

blunt/no autonomic responses

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7
Q

factors that decrease MAC (12)

A
  1. hypothermia
  2. severe hypotension
  3. age
  4. opioids/ketamine
  5. chronic amphetamine use
  6. reserpine/a-methyldopa
  7. cholinesterase inhibitors
  8. IV LA
  9. pregnancy
  10. hypoxemia- PaO2 < 40
  11. anemia
  12. a2-agonists
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8
Q

factors that increase MAC (5)

A
  1. hyperthermia
  2. hyperthyrodism
  3. alcoholism
  4. dextroamphetamine
  5. young age
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9
Q

factors that DO NOT effect MAC (6)

A
  1. duration of anesthesia
  2. sex
  3. metabolic acid-base status
  4. hypercapnia/hypocapnia
  5. isovolemic anemia
  6. hypertension
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10
Q

awareness

A

postop recall of events occurring during GA

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11
Q

amnesic wakefulness

A

responsiveness during GA without postop recall

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12
Q

dreaming

A

any experience that patients are able to recall postop that they think occurred during GA & that they believe is dreaming

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13
Q

explicit memory

A

conscious recollection of previous experiences (awareness)

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14
Q

implicit memory

A

changes in performance or behavior that are produced by previous experiences but without conscious recollection of experience

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15
Q

lambda/Ostwald coefficient

A
  • mls of gas that will dissolve in 1ml of blood at 37C
  • when Pp of agent in blood and gas are in equilibrium, coefficient tells you how much agent is dissolved for each ml causing anesthesia
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16
Q

Henry’s Law

A

amount of gas that dissolves in a liquid is directly proportional to the Pp of gas over the liquid

17
Q

VRG

A
  • brain, heart, kidney, liver
  • 10% body mass ~ 75% CO
  • 70ml blood/100ml tissue/min
  • high uptake d/t perfusion
  • N2O 50% equilibrated 2 min; 90% in 4-8 min
18
Q

Muscle

A
  • 50% body mass ~ 19% CO
  • 3ml blood/100ml tissue/min
  • N2O 50% equilibrated in 20-25 min
  • Sevo 50% equilibrated in 80 min
  • full equilibration in 2-4 hours
19
Q

Fat

A
  • 20% body mass ~ 6% CO
  • 400ml/min
  • N2O 50% equilibrated in 75 min
  • Sevo 50% equilibrated in 30 hours

Anesthesia Pharm (12 decks)

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