Ketamine Flashcards
1
Q
Mechanism of action
A
- antag NMDA
- antag muscarinic
- antag monoaminergic in brain -> sedation
- agon monoamerinergic in periphery -> increased HR/BP
- agon opioid
- inhib VGCa++ channel
2
Q
Pharmacokinetics
A
- extremely lipid soluble
- hepatic metabolism -> norketamine -> hydroxylated/conjugated -> water -> renal excretion
- renal elim t1/2 2-3 hours
3
Q
CV effects
A
increase SBP, HR, SVR
4
Q
Pulmonary effects
A
no resp depression, except increased with opioid use
5
Q
CNS effects
A
increase CBF, ICP, CMRO2
**contraindicated with head injury
6
Q
Concentration
A
10 mg/ml; 50 mg/ml
7
Q
Induction dose
A
1-3 mg/kg IV
4-8 mg/kg IM
8
Q
Adjunctive analgesic dose
A
0.2-0.5 mg/kg
9
Q
Risks
A
emergence delirium- pre-med with midazolam
