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Anesthesia Pharm > Etomidate > Flashcards

Etomidate Flashcards

1
Q

Mechanism of action

A

enhance effects of GABA at GABA(A) receptor with beta3 subunit

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2
Q

Time to unconsciousness

A

30-60 sec with rapid awakening

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3
Q

Pharmacokinetics

A
  • 75% protein bound
  • renal/biliary elimination t1/2 75min
  • ester hydrolysis to inactive metabolites
  • CL 5x that of pentothal
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4
Q

CV effects

A

no change SBP, HR, SVR

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5
Q

Pulmonary effects

A

minimal resp depression, however increased with opioids

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6
Q

CNS effects

A

decreased CBF, ICP, CMRO2

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7
Q

Concentration

A

2mg/ml

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8
Q

Induction dose

A

0.2-0.4 mg/kg

burns on injection

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9
Q

Risks

A
  • myoclonus- spontaneous jerking
  • adrenal suppression- inhibits 11beta- and 17alpha-hydroxylase -> decrease cortisol/aldosterone
  • increase PONV
  • NO analgesia
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Anesthesia Pharm (12 decks)

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