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pharmacy stage 2 > upper GI disorders: dyspepsia > Flashcards

upper GI disorders: dyspepsia Flashcards

1
Q

symptoms of PUD (peptic ulcer disease)

A

gastric ulcer pain made worse by food

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2
Q

major cause of PUD

A 
Caffeine 'smoking 
alcohol 
NSAID 
stress 
H. pylori
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3
Q

why does long term use of NSAID cause peptic ulceration

A

NSAID block COX enzymes and decrease Prostaglandin production

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4
Q

gastric ulceration is associated with what kind of acid secretion

A

decreased

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5
Q

duodenal ulceration is associated with what kind of acid secretion

A

increased

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6
Q

gastic ulcers are normally where

A

whole gastric area

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7
Q

dudoenal ulcers are normally where

A

antrial/pyloric region

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8
Q

which ulcer has less acid secreted

A

gastric

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9
Q

how can gastric damage through NSAID be prevented

A

use PEG1 analogue

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10
Q

COX-2 is switched on

A

sometimes

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11
Q

COX-1 is switched on

A

all the time

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12
Q

disadavantages of systemic anatacids

A

overload in kidneys

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13
Q

diadvantages of non-systemic antacids

A

most of dose stays in GI tract

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14
Q

adverse effects of magnesium hydroxide

A

laxative effect

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15
Q

magnesium antacids should not be used where

A

renal failure

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16
Q

mechanism of action of alginates

A

reacts with acids to form raft of alginic-acid gel

17
Q

how is HCi released from parietal cells

A
  • activate gastric receptors
  • activate muscarinic receptors through Ach
  • activate H2 receptor through histamine
18
Q

how can you stop Acid production from parietal cells

A

PPI
stop histamine receptor
block muscarinic receptor

19
Q

whih drug isnt used clinically

A

muscarinic receptor antagonists

20
Q

PPI act on what cells

A

parietal

21
Q

PPI’s end in what

A

azole

22
Q

which drugs are enteric coated

A

PPI

23
Q

PPI are a type of what

A

pro drug

24
Q

how do PPI work

A

active form irreversibly binds to cysteins of H+/K+ of ATPase inhibitting active proton pump
this prevent H+ movement from parietal cells to stomach
this causes gastric acid secretion to be blocked

25
Q

name two H2 receptor blockers

A

cimetidine

ranitidine

26
Q

Mechanism of action of H2 receptor

A

affects P450 pathway

27
Q

are H2 receptor antagonists competive or not

A

competitive

pharmacy stage 2 (11 decks)

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