Untitled Deck Flashcards
What are glycosaminoglycans?
Glycosaminoglycans are long, rigid molecules made of repeating disaccharides that are negatively charged.
What is an example of a glycosaminoglycan?
Hyaluronic acid is an example of glycosaminoglycan.
What are the characteristics of glycosaminoglycans?
They are µm long, negatively charged, bind to cations, and cause hydration shells.
What effect does cation binding have on glycosaminoglycans?
Cation binding increases osmotic pressure in hydration shells, allowing cells to slide.
What receptors does hyaluronan bind to?
Hyaluronan can bind to CD44 receptors.
What is Synvisc One?
Synvisc One is a treatment for osteoarthritis in the knee involving hyaluronan.
What are proteoglycans?
Proteoglycans are a combination of proteins and glycosaminoglycans.
What are syndecans?
Syndecans are a type of proteoglycan that can bind fibroblast growth factors.
What is Syndecan I’s role?
Syndecan I controls hunger, and too much is linked to obesity.
What is fibronectin?
Fibronectin is a multiadhesive dimer that binds to cells via integrin receptors and is important in morphogenesis.
What is laminin?
Laminin is a multiadhesive trimer that can self-assemble into laminin sheets.
What did the experiments with Pc12 cells show?
The experiments showed that laminin supports a neuronal phenotype.
What are integrin receptors?
Integrin receptors are proteins that bind to components of the ECM and can bind to most but not all ECM components.
What are the characteristics of integrin receptors?
Most require cations, are dimers, have low affinity to their ligands, and exist in three states: inactive, low activity, and high activity.
What is extravasation?
Extravasation is the process where white blood cells go to the site of infection by attaching and slipping through capillary endothelial cells.
