Unit6: Chapter 47 (Karch 7th Ed) - Lipid-Lowering Agents Flashcards
- When planning patient care the nurse recognizes what patient is at greatest risk of developing coronary
artery disease?
A) A 32-year-old Asian American with total cholesterol of 120 mg/dL
B) A 62-year-old white American with total cholesterol of 260 mg/dL
C) A 48-year-old African American with total cholesterol of 198 mg/dL
D) A 26-year-old Native American with total cholesterol of 150 mg/dL
Ans: B
Feedback:
White Americans have the highest incidence of coronary artery disease (CAD). This patient has total
cholesterol of 260 mg/dL, which is considered high according to the Third Report of the National
Cholesterol Education Program Expert Panel. The other three patients could be at risk due to cultural
risk factors such as hypertension, diabetes, high (HDL) and low density lipoprotein (LDL) levels, and
HDL level to cholesterol ratio. However, their total cholesterol levels fall within normal or desirable
range.
- The nurse is assessing a patient who reports taking cholestyramine (Questran) mixed with diet cola
twice per day. What is an appropriate nursing diagnosis for this patient?
A) Acute pain related to central nervous system and GI effects
B) Constipation related to GI effects
C) Noncompliance related to how the drug is taken
D) Deficient knowledge regarding drug therapy
Ans: D
Feedback:
Cholestyramine should be mixed with water or other noncarbonated fluids so the nurse now recognizes
the need for medication teaching and chooses the nursing diagnosis related to deficient knowledge.
Nothing in this question indicates that the patient is experiencing any adverse effects from the drug so
that pain and constipation would not be optimal nursing diagnoses. Until the nurse assesses the
patient’s understanding of how to take the drug, it would be incorrect to assume noncompliance when it may actually be lack of understanding
- A patient tells the nurse he has had an exacerbation of hemorrhoidal irritation. What drug would the
nurse suspect is most likely to contribute to this adverse effect?
A) Bile acid sequestrants
B) Beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
C) Cholesterol absorption inhibitor
D) Fibrates
Ans: A
Feedback:
Direct gastrointestinal (GI) irritation, including nausea, constipation that may progress to fecal
impaction, and aggravation of hemorrhoids, may occur with use of bile acid sequestrants. GI irritation,
and specifically irritation of hemorrhoids is not associated with use of HMG-CoA reductase inhibitors,
cholesterol absorption inhibitors, or fibrates.
- The nurse is engaged in patient teaching about a newly prescribed bile acid sequestrant that may be
mixed with a carbonated beverage. What bile acid sequestrant is the nurse describing?
A) Cholestyramine (Questran)
B) Colesevelam (Welchol)
C) Colestipol (Colestid)
D) Ezetimibe (Zetia)
Ans: C
Feedback:
Colestipol can be mixed with a carbonated beverage. The mixture should be stirred and all of the liquid
should be swallowed. Ezetimibe is a cholesterol absorption inhibitor and comes in tablet form. The
other two options are bile acid sequestrants, but should not be taken with carbonated beverages. The
carbonation interferes with the absorption of the drug.
- The patient asks the nurse what atorvastatin (Lipitor), newly prescribed, will do. What expected
outcome will the nurse describe?
A) Decrease in serum cholesterol only
B) Decrease in serum cholesterol and low density lipoprotein (LDL) levels
C) Decrease in sitosterol and serum cholesterol
D) Decrease in campesterol and LDL levels
Ans: B
Feedback:
Atorvastatin is a beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor and should lower
serum cholesterol and LDL levels as well as prevention of a first myocardial infarction and slow the
progression of coronary artery disease. A decrease in serum cholesterol alone would result from the use
of a bile acid sequestrant. A cholesterol absorption inhibitor would also decrease sitosterol and
campesterol levels as well as decrease levels of serum cholesterol and LDL.
- The nurse is taking a health history on a 38-year-old man who is taking atorvastatin (Lipitor) for high
cholesterol. What will the nurse question specifically related to the safe use of this drug?
A) Alcohol
B) Nicotine
C) Caffeine
D) Herbal therapy
Ans: A
Feedback:
Beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are contraindicated
with active liver disease or a history of alcohol-related liver disease so it is important for the nurse to
ask about the patient’s use of alcohol. Nicotine, caffeine, and herbal therapies are usually not identified
as producing any drug drug interactions with atorvastatin.
- A 9-year-old child has received an order for oral pravastatin (Pravachol) 40 mg/d for genetically linked
hyperlipidemia. In preparation for patient teaching concerning this drug, what initial action will the
nurse take?
A) Ask the parents to be present for the teaching session.
B) Determine the appropriate time to discuss the drug with the patient.
C) Question the doctor concerning the ordered dosage.
D) Review the child’s normal daily dietary intake of fatty foods.
Ans: C
Feedback:
The nurse should question the order initially. The dosage is twice the dose for a 9-year-old is expected
to receive. The other options are appropriate and would be done. However, out of safety concerns, the
nurse would clarify the dosage first.
8. The nurse is caring for a patient taking ezetimibe (Zetia) and monitors the patient for what common adverse effects? A) Bloating and flank pain B) Neuropathy and flatulence C) Mild abdominal pain and diarrhea D) Constipation and flank pain
Ans: C
Feedback:
The most common adverse effects of ezetimibe are mild abdominal pain and diarrhea. Bloating and
flatulence are associated with bile acid sequestrants and the fibrates. Constipation is usually associated
with bile acid sequestrants. Neuropathy and flank pain are usually not associated with lipid-lowering
agents.
- The nurse is preparing a patient for discharge who will receive a prescription for an beta-hydroxy-betamethylglutaryl
coenzyme A (HMG-CoA) inhibitor. What statement by the patient demonstrates that
they have a clear understanding of the teaching provided by the nurse?
A) I will not need to follow that low-fat diet anymore because this drug will take care of my lipids.
B) I should plan to take this drug before bedtime, because my body makes lipids mostly at night.
C) After I start taking this drug, I will not have to worry about the exercise routine the doctor
prescribed.
D) I should take this drug first thing in the morning and make sure I drink a full glass of water.
Ans: B
Feedback:
HMG-CoA inhibitors should be taken at bedtime because the body produces lipids mostly at night. Diet
and exercise are still important when taking these drugs because the drug is most effective in
combination with other lipid-lowering actions
- A patient taking atorvastatin (Lipitor) comes to the clinic with complaints of acute muscle pain not
associated with exercise or injury. The nurse will ask questions to determine if this patient has been
taking what contraindicated substance?
A) Over-the-counter (OTC) medications
B) Ginseng
C) Grapefruit juice
D) Saw palmetto
Ans: C
Feedback:
Grapefruit juice can decrease the breakdown of atorvastatin, leading to increased serum levels and toxic
adverse effects, including rhabdomyolysis. Patients on this drug should be cautioned to avoid drinking
grapefruit juice. OTC drugs, ginseng, and saw palmetto are not associated with increased toxicity
- What are the most common adverse effects of lovastatin (Mevacor)?
A) Nausea, flatulence, and constipation
B) Increased appetite and blood pressure
C) Confusion and mental disorientation
D) Hiccups, sinus congestion, and dizziness
Ans: A
Feedback:
GI problems such as nausea, vomiting, flatulence, constipation, or diarrhea can occur with lovastatin.
Increased appetite is not associated with lovastatin but patients may think that taking this drug means
they can now eat anything they want and this would indicate the need for further teaching. Confusion and mental disorientation are not associated with this drug. Hiccups, sinus congestion, and dizziness
would require exploration for cause because they are not normally associated with lovastatin therapy.
- The patient receives a prescription for niacin and the nurse is teaching his or her about the medication.
The nurse instructs the patient to call the provider if what common adverse effect of niacin occurs?
A) Hypotension
B) Abdominal pain
C) Vomiting
D) Diarrhea
Ans: B
Feedback:
Niacin is associated with intense cutaneous flushing, nausea, and abdominal pain, making its use
somewhat limited. It also increases serum levels of uric acid and may predispose patients to the
development of gout. Hypotension, vomiting, and diarrhea are not normally associated with the drug
- The nurse is providing medication teaching to a patient who will begin taking niacin with a bile acid
sequestrant. How does the nurse instruct the patient to take these two medications?
A) Both medications should be taken 4 to 6 hours apart.
B) Both medications should be taken in the morning.
C) One medication should be taken in the morning but the other is taken at bedtime.
D) Both medications can be taken at once just before going to bed.
Ans: A
Feedback:
When niacin is prescribed with a bile acid sequestrant, the patient should be told to take the two
medications 4 to 6 hours apart in the evening, with the niacin normally taken first.
- The nurse is teaching a patient about a peroxisome proliferator receptor alpha activator named Trilipix
(fenofibric acid). The patient asks what this drug does. What is the nurse’s best response?
A) Micelles are absorbed into the intestinal wall and combined with proteins to become chylomicrons
B) The drug makes the liver use cholesterol to produce more bile acids.
C) The drug works in the brush border of the small intestine to prevent the absorption of dietary
cholesterol.
D) The drug activates a specific hepatic receptor, resulting in increased breakdown of lipids and
reduction in triglyceride levels.
Ans: D
Feedback:
Fenofibric acid is the first drug in this class. It activates a specific hepatic receptor that results in
increased breakdown of lipids, elimination of triglyceride-rich particles from the plasma and reduction
in the production to an enzyme that naturally inhibits lipid breakdown. The result is seen as a decrease
in triglyceride levels, changes in low density lipoprotein production, which makes them more easily
broken down in the body, and an increase in high density lipoprotein levels.
- The nurse conducts a review of research related to Beta-hydroxy-beta-methylglutaryl coenzyme A
inhibitors and finds the only one associated with data to show a reduction in coronary artery disease and
incidence of myocardial infarction is what drug?
A) Pravastatin (Pravachol)
B) Lovastatin (Mevacor)
C) Atorvastatin (Lipitor)
D) Fluvastatin (Lescol)
Ans: A
Feedback:
Pravastatin is the only statin with outcome data to show effectiveness in decreasing coronary artery
disease and incidence of myocardial infarction (MI); it prevents a first MI even in patients who do not
have a documented elevated cholesterol level. The other medications do not have any evidence of
effectiveness for this patient