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B&L random > Unit II > Flashcards

Unit II Flashcards

1
Q

Neutrophils in storage pool

A

metameyelocytes, bands and segmented neutrophils

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2
Q

Neutrophils in mitotic pool

A

myleloblast, promyelocyte, and meyelocytes

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3
Q

ANC: normal- 500 microliters

A

mild risk of infection

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4
Q

ANC

A

moderate to severe risk of infection

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5
Q

ANC:

A

very severe risk of infection

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6
Q

Location of Th0 cells

A

paracortex of lymph nodes

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7
Q

Tfh- separate lineage from Th1 and Th2?

A

NO acquire surface marker (CXCR5)

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8
Q

Phenotype of Treg

A

CD4/CD25

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9
Q

Lack Treg?

A

autoimmunity

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10
Q

Treg speceficity

A

NO antigen specificity- suppress any Th cell

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11
Q

Cytokine that converts CTLs to memory cells

A

IL-21

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12
Q

How do you distinguish Th1 and Th2 cells?

A

Look at lymphokines they make

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13
Q

HLA gene is on chromosome ___

A

6

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14
Q

Stromal cells are more concentrated in the ___ of the thymus

A

medulla

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15
Q

Only lymphoid organ that does not contain reticular fibers

A

thymus- no bulk flow of fluid through it

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16
Q

Smallpox

A

has been eliminated by vaccination

17
Q

Rabies

A
  • active immunization is possible

- HOWEVER if someone is bit, you can immunize after because progression is so slow

18
Q

Conjugate vaccines are effective in

A

babies and elderly

19
Q

RotaShield

A

intussusception

- hypertrophy of Peyer’s patches

20
Q

2 safer alternatives to RotaShield

A
  • RotaTeq

- RotaRix

21
Q

Influenza virus is rarely associated with

A

Guillain-Barre syndrome

22
Q

Adjuvants lead to

A

innate immune response-> more effective adaptive response

23
Q

Most common approved adjuvant

A

alum

24
Q

alum mimics

A

certain PAMPs

25
Q

Only FDA-approved adjuvant

A

Lipid A, part of endotoxin

Added to Cervarix

26
Q

Sabin

A

attenuated, live, oral-> high levels of IgA

27
Q

Salk

A

killed, injected-> IgG

28
Q

No antibody>->

A

T cell response required

29
Q

If mother has rubella in first eight weeks of gestation, the likelihood of fetal infection is

A

50%

30
Q

Advantage of DNA vaccines

A

speed, can be available rapidly

31
Q

Protein and killed viruses are given:

A

early

32
Q

Live viruses are given after

A

1 year

33
Q

MMR is given at

A

1 year

34
Q

4 decreased bone marrow production:

A
  1. Kostmann syndrome
  2. Shwachman- Diamon syndrome
  3. Cyclic neutropenia
  4. Idiopathic neutropenia
35
Q

Patients with neutropenia are most susceptible to:

A
  • Staphylococcus aureus and gram negative bacteria
36
Q

Monocytosis foun in (5)

A
  1. hematologic malignancies
  2. Collagen vascular diseases
  3. granulomatous diseases
  4. Infections
  5. carcinoma
37
Q

Chronic granulomatous disease (CGD) is a deficiency in (4)

A
  1. gp91phox
  2. p22phox
  3. p47phox
  4. p67phox

B&L random (6 decks)

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