Unit II

Question 1

Neutrophils in storage pool

Answer 1

metameyelocytes, bands and segmented neutrophils

Question 2

Neutrophils in mitotic pool

Answer 2

myleloblast, promyelocyte, and meyelocytes

Question 3

ANC: normal- 500 microliters

Answer 3

mild risk of infection

Question 4

ANC

Answer 4

moderate to severe risk of infection

Question 5

ANC:

Answer 5

very severe risk of infection

Question 6

Location of Th0 cells

Answer 6

paracortex of lymph nodes

Question 7

Tfh- separate lineage from Th1 and Th2?

Answer 7

NO acquire surface marker (CXCR5)

Question 8

Phenotype of Treg

Answer 8

CD4/CD25

Question 9

Lack Treg?

Answer 9

autoimmunity

Question 10

Treg speceficity

Answer 10

NO antigen specificity- suppress any Th cell

Question 11

Cytokine that converts CTLs to memory cells

Answer 11

IL-21

Question 12

How do you distinguish Th1 and Th2 cells?

Answer 12

Look at lymphokines they make

Question 13

HLA gene is on chromosome ___

Answer 13

6

Question 14

Stromal cells are more concentrated in the ___ of the thymus

Answer 14

medulla

Question 15

Only lymphoid organ that does not contain reticular fibers

Answer 15

thymus- no bulk flow of fluid through it

Question 16

Smallpox

Answer 16

has been eliminated by vaccination

Question 17

Rabies

Answer 17

• active immunization is possible

- HOWEVER if someone is bit, you can immunize after because progression is so slow

Question 18

Conjugate vaccines are effective in

Answer 18

babies and elderly

Question 19

RotaShield

Answer 19

intussusception

- hypertrophy of Peyer’s patches

Question 20

2 safer alternatives to RotaShield

Answer 20

• RotaTeq

- RotaRix

Question 21

Influenza virus is rarely associated with

Answer 21

Guillain-Barre syndrome

Question 22

Adjuvants lead to

Answer 22

innate immune response-> more effective adaptive response

Question 23

Most common approved adjuvant

Answer 23

alum

Question 24

alum mimics

Answer 24

certain PAMPs

Question 25

Only FDA-approved adjuvant

Answer 25

Lipid A, part of endotoxin | Added to Cervarix

Question 26

Sabin

Answer 26

attenuated, live, oral-> high levels of IgA

Question 27

Salk

Answer 27

killed, injected-> IgG

Question 28

No antibody>->

Answer 28

T cell response required

Question 29

If mother has rubella in first eight weeks of gestation, the likelihood of fetal infection is

Answer 29

50%

Question 30

Advantage of DNA vaccines

Answer 30

speed, can be available rapidly

Question 31

Protein and killed viruses are given:

Answer 31

early

Question 32

Live viruses are given after

Answer 32

1 year

Question 33

MMR is given at

Answer 33

1 year

Question 34

4 decreased bone marrow production:

Answer 34

1. Kostmann syndrome 2. Shwachman- Diamon syndrome 3. Cyclic neutropenia 4. Idiopathic neutropenia

Question 35

Patients with neutropenia are most susceptible to:

Answer 35

- Staphylococcus aureus and gram negative bacteria

Question 36

Monocytosis foun in (5)

Answer 36

1. hematologic malignancies 2. Collagen vascular diseases 3. granulomatous diseases 4. Infections 5. carcinoma

Question 37

Chronic granulomatous disease (CGD) is a deficiency in (4)

Answer 37

1. gp91phox 2. p22phox 3. p47phox 4. p67phox