Unit 6 Study Guide Flashcards
Epicardium
- outermost layer
- also called the visceral layer of serous pericardium
- composed of simple squamous epithelium and an underlying layer of areolar connective tissue
- as we age, the epicardium thickens as it becomes more invested with adipose connective tissue
- Heart receives nutrients from coronary vessels
Myocardium
- middle layer of the hart
- composed of cardiac muscle tissue
- thickest of the three layers
- contraction of this muscle generates the force necessary to pump blood
Endocardium
- covers the internal surface of the heart and external surface of the heart valves
- composed of simple squamous epithelium and an underlying layer of areolar connective tissue
- Epithelial layer of the endocardium is continuous with the epithelial layer of the endothelium - lines blood vessels
Atrioventricular Valves
Right:
- covers the right atrioventricular opening
- has three cusps (tricuspid)
Left:
- covers the left atrioventricular opening
- has two cusps (bicuspid)
When the cusps are open
allows blood to move from an atrium into the ventricle
when the ventricles contract
- blood is force superiorly as ventricular pressure rises, which causes AV valves to close.
AV valves
prevent blood flow back into the atrium
Semilunar valves
- pulmonary semilunar valve
- aortic semilunar valve
pulmonary semilunar valve
- located between the right ventricle and pulmonary trunk
aortic semilunar valve
- located between the left ventricle and the ascending aorta
The semilunar valves open when
- the ventricles contract and the force of blood pushes the semilunar valves open and blood enters the arterial trunks.
the semilunar valves close when
- the ventricles relax and the pressure in the ventricles becomes less than the pressure in an arterial trunk
- prevents back flow into the ventricle
function of the fibrous skeleton of the heart
- provides structural support at the boundary between the atria and the ventricles
- forms supportive fibrous rings to anchor the heart valves
- provides a rigid framework for the attachment of cardiac muscle tissue
- acts as an electrical insulator because it does not conduct action potentials and thus prevents the ventricle chambers from contracting at the same time as the atrial chambers.
sarcolemma
- invaginate to form T-tubules that extend to the SR.
T-tubules
- invaginate one per sarcomere and overlie Z discs.
sarcoplasmic reticulum
- surrounds bundles of myofilaments called myofibrils in cardiac muscle, but is less extensive than the SR in skeletal muscle and lacks both terminal cistern and a tight association with T-tubules.
myofilaments
- arranged in sarcomeres and appear striated.
Overlap of thick and thin filaments
- does not occur when cardiac muscles are at rest.
- occurs when cardiac muscle is stretched as blood is added to the chamber.
intercalated discs
link cardiac muscle cells mechanically and electrically.
desmosomes
- act as mechanical junctions to prevent cardiac muscle cells from pulling apart in times of stress/friction.
gap junctions
- provide a low-resistance pathway for the flow of ions between the cardiac cells. Allow an action potential to move continuously along the sarcolemma of cardiac muscle cells, resulting in synchronous contraction of that chamber - functional synctyium
conduction system
- electrical activity is initiated at the SA node, and an action potential is then transmitted through the conduction system
cardiac muscle cells
- the action potential spreads across the sarcolemma of the cardiac muscle cells, causing sarcomeres within cardiac muscle cells to contract.
- these events occur twice in cardiac muscle cells of the atria and then again in the ventricles
Nodal cells
- located in the SA node
- pacemaker cells
- initiate a heartbeat by spontaneously depolarizing to generate an AP
resting membrane potenital
-60 mV
autorhythmicity
- capable of depolarizing and firing an AP spontaneously without any external influence.
reaching threshold
- slow voltage-gated Na+ channels open (repolarization from previous cycle).
- Na+ flows into nodal cells, changing RMP from -60 mV to -40 mV which is threshold value
- without outside stimulation
depolarization
- changing of the membrane potential to threshold potential triggers opening of fast voltage-gated Ca2+ channels
- Ca2+ entry into nodal cells cause a change in the membrane potential from -40 mV to a slightly positive value (just above 0 mV)
repolarization
- calcium channels close and voltage-gated K+ channels open
- K+ flows out to change the membrane potential back to -60 mV.
- depolarization triggers the reopening of slow voltage-gated Na+ channels