UNIT 6: CENTRAL NEUROTRANSMITTERS (PART 2) Flashcards by elowiz <3

Q

T/F

Neurotransmitter must be present in higher concentratiuon in the synaptic area than in other areas

A

True

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Q

T/F

Neurotransmitters are released by electrical or chemical stimulation via calcium-dependent mechanism

A

True

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Q

T/F

Synaptic Mimicry is the production of same postsynaptic response and is seen with physiologic activation of the synapse

A

True

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Q

Which Neurotransmitter is being described:
G protein-coupled muscarininc M1 Receptors?

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

a. Acetylcholine

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Q

Which Neurotransmitter is being described:
* Slows excitation
* Decreeases permeanility to potassium

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

a. Acetylcholine

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Q

Which Neurotransmitter is being described:
* Increases cAMP

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

b. Dopamine

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Q

Which Neurotransmitter is being described
* G protein-coupled activation of K+ channels

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

b. Dopamine

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Q

Which Neurotransmitter is being described
* has both excitatory and inhibitory response

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

c. Norepinephrine

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Q

Which Neurotransmitter is being described
* Excitatory: decreases K+ conductance

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

c. Norepinephrine

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Q

Which Neurotransmitter is being described
* Inhibitory: increases K+ conductance

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

c. Norepinephrine

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Q

Which Neurotransmitter is being described
* Multip;e 5 hydroxytrptamine
* Excitatoru depending on the receptor subtype activated

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. Serotonin

A

d. Serotonin

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Q

Which Neurotransmitter is being described
* Excitatory for most neurons
* NMDA receptor
* Inhibition of adenyl cyclase

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

Glutamic Acid

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Q

Which Neurotransmitter is being described
* Primary NTA mediating IPSPs

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

GABA

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Q

Which Neurotransmitter is being described
* Numerous in the cord
* Inhibitory
* Increase CL conductance

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

Glycine

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Q

Which Neurotransmitter is being described
* Beta-endorphins, dynorphins

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

Opiod Peptides

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Q

List Amino Acid Neurotransmitters

A

Glutamate
GABA
Glycine

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Q

Amino Acid NTA that mediates excitatory synaptic transmission

a. Glutamate
b. GABA & Glycine

A

Glutamate

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Q

T/F

Glutamate interact with AMPA and NMDA (ionotropic receptor) on presynaptic and MGLUR (metabotropic) on posysynaptic

A

True

Q

Aminoacid NTA that is inhibitory neurotransmitter
a. Glutamate
b. Gaba
c. Glycine
d. Both b and c

A

d. Both b and c

Q

Inhibitory NTA present throughtout the CNS including the spinal cord

a. GABA
b. Glycine
c. Both a & b

A

GABA

Q

Inhibitory NTA present in Spinal Cord and Brain Stem

a. GABA
b. Glycine
c. Both a & b

A

b. Glycine

Q

Its receptors are pentameric sturctures and are selectively permeable to CL-
a. GABA
b. Glycine
c. Both a & b

A

b. Glycine

Q

A potent spinal cord convulsant that selectively blocks glycine receptors

A

Strychnine

Q

Ionotropic Receptor ** which Pentameric structures that are selectively permeable to Cl-**

a. GABAa
b. GABAb

A

a. GABAa

NTA that Causes slow inhibition of the neuron by activating the M2 subtype of receptor, which opens potassium channels. a. Acetylcholine b. Dopamine c. Norepinephrine d. Histamine

a. Acetylcholine

**Metabotropic receptor that is**Selectively activated by the antispastic drug **baclofen.** a. GABAa b. GABAb

b. GABAb

NTA that mediates large family of G protein-coupled muscarining receptors a. Acetylcholine b. Dopamine c. Norepinephrine d. Histamine

a. Acetylcholine

List down the Monoamine Neurotransmitters

a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

Which Monoamine NTA is described * all are metabotropic * Exerts slow inhibitory actions a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

a. Dopamine

Which Monoamine transmitter is described * located in the locus coeruleus or lateral tegmental area of the reticular formation a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

b. Norepinephrine

Which Monoamine transmitter is described * Hyperpolarizes neurons by increasing potassium conductance a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

b. Norepinephrine

Which Monoamine transmitter is described * Enhances excitatory by both direct and indirect mechanism a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

b. Norepinephrine

Which Monoamine transmitter is described * Contained in unmyelinated fibers that diffusely innervate most regions of the CNS a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

c. 5-hydroxytryptamine

Which Monoamine transmitter is described * Both excitatory and inhibitory actions can occur on the same neuron * Regulates brain functions a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

c. 5-hydroxytryptamine

Which Monoamine transmitter is described * Originated from neurons in the midline raphe nuclei of the pons and upper brain stem a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

c. 5-hydroxytryptamine

Which Monoamine transmitter is described * Made in the tuberomammillary nucleus * all are matobotropic * for sedative properties a. Dopamine b. Norepinephrine c. 5-hydroxytryptamine d. Histamine

d. Histamine

Neuropeptide produced in the lateral and posterior hypothalamus

Orexin

Neuropeptide that releases glutamate

Orexin

Neuropeptide that Exhibit firing patterns associated with wakefulness and project to and activate monoamine and acetylcholine neurons involved in sleep-wake cycles.

Orexin

List the other signaling substances

* Endocanbinoids * Nitric Oxide * Purines

Which other signaling substance is described? * Activated by calcium-calmodulin * Activation of NMDA receptors a. Endocannibinoids b. Nitric Oxide c. Purines

d. Nitric Oxide

Which other signaling substance is described? * Can function as retrograde synaptic messengers a. Endocannibinoids b. Nitric Oxide c. Purines

a. Endocannibinoids