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alien pcol > UNIT 6: CENTRAL NEUROTRANSMITTERS (PART 2) > Flashcards

UNIT 6: CENTRAL NEUROTRANSMITTERS (PART 2) Flashcards

1
Q

T/F

Neurotransmitter must be present in higher concentratiuon in the synaptic area than in other areas

A

True

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2
Q

T/F

Neurotransmitters are released by electrical or chemical stimulation via calcium-dependent mechanism

A

True

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3
Q

T/F

Synaptic Mimicry is the production of same postsynaptic response and is seen with physiologic activation of the synapse

A

True

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4
Q

Which Neurotransmitter is being described:
G protein-coupled muscarininc M1 Receptors?

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

a. Acetylcholine

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5
Q

Which Neurotransmitter is being described:
* Slows excitation
* Decreeases permeanility to potassium

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

a. Acetylcholine

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6
Q

Which Neurotransmitter is being described:
* Increases cAMP

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

b. Dopamine

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7
Q

Which Neurotransmitter is being described
* G protein-coupled activation of K+ channels

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

b. Dopamine

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8
Q

Which Neurotransmitter is being described
* has both excitatory and inhibitory response

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

c. Norepinephrine

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9
Q

Which Neurotransmitter is being described
* Excitatory: decreases K+ conductance

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

c. Norepinephrine

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10
Q

Which Neurotransmitter is being described
* Inhibitory: increases K+ conductance

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. serotonin

A

c. Norepinephrine

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11
Q

Which Neurotransmitter is being described
* Multip;e 5 hydroxytrptamine
* Excitatoru depending on the receptor subtype activated

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. Serotonin

A

d. Serotonin

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12
Q

Which Neurotransmitter is being described
* Excitatory for most neurons
* NMDA receptor
* Inhibition of adenyl cyclase

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

Glutamic Acid

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13
Q

Which Neurotransmitter is being described
* Primary NTA mediating IPSPs

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

GABA

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14
Q

Which Neurotransmitter is being described
* Numerous in the cord
* Inhibitory
* Increase CL conductance

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

Glycine

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15
Q

Which Neurotransmitter is being described
* Beta-endorphins, dynorphins

a. Glutamic Acid
b. GABA
c. Glycine
d. Opioid Peptides

A

Opiod Peptides

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16
Q

List Amino Acid Neurotransmitters

A
  • Glutamate
  • GABA
  • Glycine
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17
Q

Amino Acid NTA that mediates excitatory synaptic transmission

a. Glutamate
b. GABA & Glycine

A

Glutamate

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18
Q

T/F

Glutamate interact with AMPA and NMDA (ionotropic receptor) on presynaptic and MGLUR (metabotropic) on posysynaptic

19
Q

Aminoacid NTA that is inhibitory neurotransmitter
a. Glutamate
b. Gaba
c. Glycine
d. Both b and c

A

d. Both b and c

20
Q

Inhibitory NTA present throughtout the CNS including the spinal cord

a. GABA
b. Glycine
c. Both a & b

21
Q

Inhibitory NTA present in Spinal Cord and Brain Stem

a. GABA
b. Glycine
c. Both a & b

A

b. Glycine

22
Q

Its receptors are pentameric sturctures and are selectively permeable to CL-
a. GABA
b. Glycine
c. Both a & b

A

b. Glycine

23
Q

A potent spinal cord convulsant that selectively blocks glycine receptors

A

Strychnine

24
Q

Ionotropic Receptor ** which Pentameric structures that are selectively permeable to Cl-**

a. GABAa
b. GABAb

25
Q

NTA that Causes slow inhibition of the neuron by activating the M2 subtype of receptor, which opens potassium channels.

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. Histamine

A

a. Acetylcholine

26
Q

Metabotropic receptor that isSelectively activated by the antispastic drug baclofen.

a. GABAa
b. GABAb

27
Q

NTA that mediates large family of G protein-coupled muscarining receptors

a. Acetylcholine
b. Dopamine
c. Norepinephrine
d. Histamine

A

a. Acetylcholine

28
Q

List down the Monoamine Neurotransmitters

A

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

29
Q

Which Monoamine NTA is described
* all are metabotropic
* Exerts slow inhibitory actions

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

a. Dopamine

30
Q

Which Monoamine transmitter is described
* located in the locus coeruleus or lateral tegmental area of the reticular formation

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

b. Norepinephrine

31
Q

Which Monoamine transmitter is described
* Hyperpolarizes neurons by increasing potassium conductance

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

b. Norepinephrine

32
Q

Which Monoamine transmitter is described
* Enhances excitatory by both direct and indirect mechanism

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

b. Norepinephrine

33
Q

Which Monoamine transmitter is described
* Contained in unmyelinated fibers that diffusely innervate most regions of the CNS

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

c. 5-hydroxytryptamine

34
Q

Which Monoamine transmitter is described
* Both excitatory and inhibitory actions can occur on the same neuron
* Regulates brain functions

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

c. 5-hydroxytryptamine

35
Q

Which Monoamine transmitter is described
* Originated from neurons in the midline raphe nuclei of the pons and upper brain stem

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

c. 5-hydroxytryptamine

36
Q

Which Monoamine transmitter is described
* Made in the tuberomammillary nucleus
* all are matobotropic
* for sedative properties

a. Dopamine
b. Norepinephrine
c. 5-hydroxytryptamine
d. Histamine

A

d. Histamine

37
Q

Neuropeptide produced in the lateral and posterior hypothalamus

38
Q

Neuropeptide that releases glutamate

39
Q

Neuropeptide that Exhibit firing patterns associated with wakefulness and project to and activate monoamine and acetylcholine neurons involved in sleep-wake cycles.

40
Q

List the other signaling substances

A
  • Endocanbinoids
  • Nitric Oxide
  • Purines
41
Q

Which other signaling substance is described?
* Activated by calcium-calmodulin
* Activation of NMDA receptors

a. Endocannibinoids
b. Nitric Oxide
c. Purines

A

d. Nitric Oxide

42
Q

Which other signaling substance is described?
* Can function as retrograde synaptic messengers

a. Endocannibinoids
b. Nitric Oxide
c. Purines

A

a. Endocannibinoids

alien pcol (4 decks)

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