UNIT 13: BETA-LACTAM ANTIBIOTICS AND OTHER CELL WALL SYNTHESIS INHIBITORS Flashcards
Antimicrobial drug that can eradicate an infection in the **absence of host defense mechanism **
a. Bactericidal
b. Bacteriostatic
a. Bactericidal
Antimicrobial drug that inhibits microbial growth that requires host defense mechanism to eradicate infection
a. Bactericidal
b. Bacteriostatic
b. Bacteriostatic
Antimicrobial drug that kills bacteria
a. Bactericidal
b. Bacteriostatic
a. Bactericidal
Antimicrobial drug that decreases growth of bacteria
a. Bactericidal
b. Bacteriostatic
b. Bacteriostatic
Bactericidal which is a cell wall inhibitor
a. Vancomycin
b. Quinolones
c. Rifampin
d. Metronidazole
a. Vancomycin
Bactericidal that is a Gyrase inhibitor
a. Vancomycin
b. Quinolones
c. Rifampin
d. Metronidazole
b. Quinolones
Bactericidal used for Tuberculosis
a. Vancomycin
b. Quinolones
c. Rifampin
d. Metronidazole
c. Rifampin
Bactericidal used for amoebiasis
a. Vancomycin
b. Quinolones
c. Rifampin
d. Metronidazole
d. Metronidazole
Drugs with structures containing beta-lactam ring
Beta-lactam Antibiotics
Stronger drugs that produce greater adverse effects
Last Resort Antimicrobials
Inhibitor to protect hydrolysable penicillin from inactivation
Beta-Lactamase Inhibitor
Lowest concentration to inhibit growth of an organism
Minimal Inhibitory Concentration
Lowest concentration of killing 99.9% of bacteria
Minimum Bactericidal Concentration
Acts as the initial receptors for penicillin and other beta-lactam antibitocs
Penicillin-Binding Proteins
T/F
PBP2a increases the affinity to drugs; decreases drug resistance
False
Decreases the affinity to drugs; increases drug resistance
Chains of polysaccharides and polypeptides that are cross-linked
Peptidoglycan
A bacterial enzyme involved in the cross-linking of linear peptidoglycan chains
Transpeptidase
T/F
In selective toxicity, It is more toxic to the host than to the invader
False! duh
It’s more toxic for the invader
T/F
Increase permeability; decrease in resistance
luh kala mo false noh
TRUE yan gaga
T/F
Adjunctive agents are Beta-Lactamase Inhibitors that can protect against antibiotic inactivation.
True GAGA
Antibiotic Combinations for Tuberculosis
clue: HINOG
R - Rifampicin
I - Isoniazid
P - Pyrazinamide
E - Ethambutol
Who discovered Penicillin G?
Alexander Flemming
From what microorganism did Penicillin G come from
Penicillium notatum
Penicillin G is primarily used for what infection?
Syphilis
Drugs without Beta-Lactam Rings
Vancomycin
Clindamycin
Fosfomycin
Bacitracin
Erythromycin
DRUGS WITHOUT BETA-LACTAM RINGS ARE CINFUL
T/F
Penicillin G cannot be taken orally because it has low availability and is digested by stomach acid
True
A derivative of Penicillin G that is resistant to stomach acids
Amoxicillin
A drug that prolongs the half-life of penicillin
Probenecid
A drug that inhibits gastric acid and therefore increases bioavailability
Probenecid
Penicillin G is used for what infection
Streptococci
Meningococci
Gram (+) bacilli
Spirochetes: Syphilis & Leptosispirosis
Microbe Resistance to Penicillin G
S. Aureus
N. gonorrhea
Treatment for S. aureus and N. gonorrhea
Ceftriaxone + Doxycycline
T/F
When it comes to enterococci infection, Penicillin G is added with Aminoglycoside to produce a synergistic effect
True
Penicillin V is used for what infection
Oropharyngeal Infection
MOA of Penicillin G
Parental
IV / IM
MOA of Penicillin V
Oral
Known as Anti-Staphylococcal Penicillin
Methicillin, Naficillin, Oxacillin
What infection is treated with Methicillin, Nafcillin, Oxacillin
Staphylococcal infections
Microbe resistance to Methicillin, Nafcillin, Oxacillin
MRSA
MRSE
Treatment for MRSA & MRSE
Vancomycin and Clindamycin and Ceftaroline
Infections treated by Ampicillin and Amoxicillin
Enterococci
Escherichia coli
Haemophilus influenzae
Listeria monocytogenes
Proteus mirabilis
Moraxella catrrhalis
Infections treated by Piperacillin and Ticarcillin
Pseudomonas
Enterobacter
Klebsiella sp.
Nafcillin causes what allergy
Neutropenia
Ampicillin causes what allergy
Maculopapular rashes
Methicillin causes what allergy
Interstitial nephritis
Ampicilin may cause what GI disturbance
Pseudo Membranous Colitis
1st Generation Cephalosphorin drugs
- Cephalexin
- Cefazolin
- Cefadroxil
- Cephalotin
- Cephadrine
- Chephaprin
tips to rember: FaPha
1st Generation Cephalosphorin used for Dermatology Skin Infection
a. Cephalexin
b. Cefazolin
a. Cephalexin
1st Generation Cephalosphorin used for Skin preparation for surgery; skin prophylaxis
a. Cephalexin
b. Cefazolin
b. Cefazolin