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T4- Nutrition > Unit 5 vit B > Flashcards

Unit 5 vit B Flashcards

1
Q

B1 active form (1)

A

Thiamine pyrophosphate (TPP)

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2
Q

main fxn of thiamine

A

nrg

Nerve& Muscle integrity & fxn
Syn of Lipids:
Syn of Nucleic Acid

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3
Q

dx caused by deficiency of B1

A

Beriberi

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4
Q

difference btw wet beriberi and dry beriberi

A
  • Adult: “wet” beriberi → affects the heart and lungs
    • Causes edema, breathing difficulty, tachycardia, CHF, heath
  • Adult “Dry” beriberi: → affects peripheral N’s
    • Cause: NO EDEMA,eye rigidity w/ nystagmus, M weakness, → bed ridden → die of infection
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5
Q

deficiency in B1 can cause cc______: numbness, tingling, mental confusion, coma

A

polyneuropathy

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6
Q

vitamer of B2

A

riboflavin

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7
Q

BAF of B2

A

FMN: oxidizing agent → can do 1 or 2 e- transfers
FMNH2
FAD: accepts and donates e-‘s . it is riboflavin attached to ADP
FADH2

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8
Q

What is the main form of riboflavin in cells

A

FMN

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9
Q

What is the cofactor for FAD

A

succinate dehydrogenase

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10
Q

name 3 flavoproteins

A

glutathione reductase- antioxidation
Monoamine oxidase - metab. of NT
Xanthine oxidase- purine nucleotide metabolism

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11
Q

vit B__ syn sphingosine → sphinolipods

A

B2

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12
Q 
deficiency sx of VitB\_\_ : 
Dermatisis: breaking open of the skin in the face
•	cheilosis 
•	glossitis
•	angular stomatitis 
•	nose
Lacrimation & photophobia
A

riboflavin Vit B2

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13
Q

vitamers of B3

A 
Niacin = Nicotinic acid 
Niacinamide= Nicotinamide
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14
Q

BAF of niacin

A

NAD/ NADH

NADP/ NADPH

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15
Q

What (5) cycles is niacin a part of

A
  • glycolysis
  • pyruvate → acetyl CoA
  • Kreb cycle
  • B-oxidation of FFA
  • PPP
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16
Q

B3 syn the lipid ___

A

NADPH

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17
Q

name the dx the a deficiency B3 causes & sx

A

pellagra

Dermatitis: casal’s necklace, inflamed lips/tongue
Diarrhea
Dementia
Death

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18
Q

Excess of niacin will cause a ____ release that causes flushing, allergies, aggresive peptic ulcers

A

Histamine release

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19
Q

vitamer of B5

A

Pantothenic acid

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20
Q

BAF of B5

A

CoASH (covered in liver)

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21
Q

B5 produces CoA for what three transactions

A

pyruvate –> acetyl CoA (pre-kreb)

a-ketogluterate–> succinyl-CoA (krebs)

b-oxidation of FA (acyl-CoA)

22
Q

name (3) lipids that are syn by B5

A

acetyle-CoA (pre-kreb)
acyl-CoA (b-oxidation)
acyl-carrier protein (ACP) of FA synthase

23
Q

VitB__ Syn of AcH and porphyrin (in Hg)

A

B5

24
Q

(3) vitamers of VitB6

A

Pyridoxine
Pyridoxal
Pyridoxamine

25
Q

BAF of B6

A

Pyridoxal phosphate (B6PO4)

26
Q

What BAF makes a coenzyme for deamination of AA to form ketoacids for NRG

A

B6: pyridoxal phosphate

27
Q 
Coenzymes for Vit B\_\_ fxn to: 
•	biosyn of AA by transamination 
•	tryptophan produces → niacin 
•	heme from succinyl-CoA
•	serine can make → glycine and sphingosine from left over AA
A

VitB 6: pyridoxine

28
Q

Vit B ___ : decarboxylation of glutamic acid → GABA

A

Vit B6

29
Q

deficiency of VitB 6 causes (2) sx

A
  • Iron-Loading Microcytic anemia: Less heme → less Fe+2 → less O2 carrying capacity of blood → microcytic RBC
  • Convulsion
30
Q

how can a deficiency in Vit B6 cause pellagra (B3)

A

VitB 6 is a coenzyme for tryptophan

no tryptophan = decrease niacin = pellagra

31
Q

toxicity of B6 can cause infantile ___

A

seizures

32
Q

toxicity of B6 can reduce the efficacy of ___ for parkinsons

A

L-DOPA

Pyridoxal phosphate (B6PO4) → increases peripheral metab. Of L-DOPA

33
Q

BAF of vit B7

A

biotin

34
Q

Fill in the blank: Vit B7

  1. _______→ succinyl –CoA→ Kreb cycle

Gluconeogenesis:
2. ________→ pyruvate to oxaloacetate

Syn of FA:
3. _______→ acetyl-CoA to malonyl-CoA

Syn of nucleic acids:
4. formation of _______ (from pyrimidine & purine)

A
  1. propionyl carboxylase
  2. pyruvate carboxylase
  3. Acetyl-CoA carboxylase
  4. carbamoyl phosphate
35
Q

There is no dietary deficiencies for Biotin, but secondary cc that can cause B7 def: (2)

A
  • Seborrheic dermatitis: dandruff/ cradle cap

* Infantile desquamative erythroderma

36
Q

B9 vitamer

A

Folate
Folacin
Folic acid

(may contain 1 to 6 molecules of glutamic acid )

37
Q

B9 BAF

A

Dihydrofolate (H2-folate)

Tetrahydrofolate (H4-folate)

38
Q

3 fxn of B9

A

• hemopoiesis (dUMP→ TMP→ DNA)
• syn purine and pyrimidine nucleotides
* histidine metab (essential AA)

39
Q

2 dx caused by B9 def

A

megaloblastic-macrocytic anemia

trophical sprue

other sx of def:
• impaired syn of Nucleotides DNA / RNA (B9 to syn need purine and pyrimidine nucleotides to make DNA/RNA)
• Homocystinemia
• Neural tube defects

40
Q

excess of VitB9 maskes a deficiency of ___

A

B12

41
Q

(3) vitamers of B12

A

Cobalamin
Cyanocobalamin
Methycobalamin

42
Q

(2) BAF of B12

A

Methylcobalamin

5’-deoxyadenosylocobalamin

43
Q

Which vitamin is the only one to contain a mineral?

What mineral does it contain?

A

Cobalamin –> contains cobalt

44
Q

What causes “methyl folate trap”

A

deficiency of B12: H4 cant → H3

45
Q

deficiency of VitB___ comes on slowly because it is stored in the liver (seen in vegetarians)

A

B12

46
Q

deficiency of VitB____ is seen in vegetarians

A

B12- most of B12 comes from meat

47
Q 
VitB \_\_\_\_ deficiency sx:
•	megaloblastic macrocytic anemia 
•	Pernicious anemia: lack of IF
•	Impaired cell division (dUMP cant go to → TMP)
•	Neuro diorders
A

B12

48
Q

(2) vitamers of Vit C

A

Ascorbic acid
Dehydroascorbic acid

  • also the BAF
49
Q

Vit C is anti-____factor

A

anti-scorbutic factor

50
Q

(2) BAF of Vit C

A

Ascorbic acid
Dehydroascorbic acid

  • also the vitamers
51
Q

Vit C enhances __ absorption

A

iron

52
Q

(2)disease of Vit C deficiency

A
  1. scurvy: gingivitis, swollen jts, aching bones, pithed frog posture, delayed wound healing
  2. Periungual hemorrhage – bleeding under the nail bed

T4- Nutrition (7 decks)

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