Unit 4 Pharmacology I: Pharmacokinetics and Pharmacodynamics Flashcards
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Plasma concentration
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Ropivacaine (pKa 8.2)
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A large amount of drug has been removed from the plasma
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Drug elimination from the central compartment
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Lidocaine
Fentanyl
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Unionized fraction of the drug increases
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Rate of metabolism
Receptor binding efficacy
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5
194
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Propofol greater than + 0.7
Midazolam + 0.3-0.7
Rocuronium + Less than 0.3
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Elimination half-time is equal to context-sensitive half-time
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More likely to undergo renal elimination
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Zero order kinetics
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Free drug is dispersed across various physiologic compartments
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200%
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Maternal alkalosis and fetal acidosis
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drug S is 1/10th as potent as Drug R
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Plasma concentration and effect-site concentration
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It is calculated by LD50/ED50
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Therapeutic index
Median effective dose
Efficacy
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Aspirin
Phenoxybenzamine
