Unit 4 - Pharmacokinetics, Absorption, Distribution, Administration

Question 1

What method of distribution do drugs follow?

Answer 1

Passive diffusion

Question 2

What does absorption extent indicate?

Answer 2

Bioavailability

Question 3

What does absorption rate refer to?

Answer 3

half-life & time to peak concentration

Question 4

What can rate and extent be influenced by?

Answer 4

Biopharmaceutical - drug formation
Physicochemical - solubility
Hydrophilicity and lipophilicity
Protein binding
Complexation characteristics with food or drugs
Physiologic factors - barrier integrity, motility, volume, pH of body fluids at the absorptive site, protein binding capacity, or degradation or biotransformation potential

Question 5

Most acids in the biological system are ______ acids hence they do not dissociate into H+ and an anion.

Answer 5

weak

Question 6

Which acid is the exception to the weak acids in the body?

Answer 6

Hydrochloric acid

Question 7

What is the pH of human blood?

Answer 7

7.35-7.45

Question 8

wHAT IS THE NORMAL