Unit 4 Flashcards
The body’s response to infection, invasion, allergies, or cancer
Immunology
2 major immune pathways
- innate response
2. adaptive response
repeat infections are cleared by which immune response
adaptive
which immune response is triggered first always?
innate response
adaptive response
triggered by the innate response and is specialized and long lasting (like the seal team 6 of the immune system)
Which immune response responds the same every time?
Innate
Which cells are red in color?
Red Blood Cells - the only cell in the body with color
These types of Myeloid progenitors help with allergy and parasite response
basophils, eosinophils, monocytes
B lymphocytes, T lymphocytes, and natural killer cells are what type of progenitors?
Lymphoid Progenitor
Kills antibody coated cells and virus infected or tumor cells
Natural Killer Cells
Produces antibody and presents antigen
B cells
has CD4 and CD8
T cells
CD4
T cell that promotes immune response and activates B cells
CD8
T cell that kills viral, tumor, nonself cells (police of your cells)
phagocytose (eat, envelope) and kill bacteria
Neutrophils
Best antigen presenters, typically trigger T cell response
Dendritic Cells
initiates inflammatory, antibacterial response with antiviral and antitumor activity
Macrophages (Big Eater)
Primary Lymphoid Organs
Thymus and Bone Marrow
Secondary Lymphoid Organs
Bone Marrow, Spleen, Lymph Nodes, and more
where is lymphoid tissue located?
lungs, intestinal tract, and urogenital tract
Where do T cells mature?
Thymus
messengers between immune cells and important for initiating immune system
cytokines
when the cells spread apart to allow things to flow through the tissue after inflammatory response
vasodilation
caused by increased blood volume at injury
inflammation
when leukocytes make it to an inflammatory site, they only phagocyte what?
Unknown or foreign microbes
type of cytokines that are chemo attractants to site of damage or infection
chemokines
Signs of illness are signs of what?
Healing
aposis
cell death
phagocyte types
neutrophils, macrophages
phagocytosis process
- bacteria is ingested, forming phagosome
- phagosome fuses with lysosome
- lysosome enzymes digest material
- digestion products are released from the cell
Cells that can produce long acting memory cells
B cells and T cells
Plasma cells secrete what?
Antibodies
T cells only recognize proteins, so they can only activate B cells against protein antigens - T/F
True
When antibodies bind to microbes or toxins, blocking them from interracting with target (body guard)
Neutralization
When antibodies bind to a microbe, making it more likely to be destroyed by phagocytes
opsonization
when antibodies bind together several microbes, making them easier to clear from body
agglutination
the process of stimulating protective adaptive immune response against microbes by exposure to nonpathogenic forms or components of microbes
vaccination
2 types of vaccination
- attenuated
2. subunit/ conjugate
Attenuated vaccines
- can’t infect the host but still retain antigens needed for a successful human response
- can passage a microbe through another organism like a mouse until it won’t infect human cells
- can mutate genome of microbe so that its virulence factors are non-functioning but still present for immune recognition
Subunit/ Conjugate Vaccines
- Antigens are separated from microbe and injected into host to trigger immune response
- inactivated toxins can be used in vaccines
- polysaccarides do not trigger T cell responses
- conjugating a polysaccharide with a protein will activate T cells and stimulate maturation of antibodies
Cholera vaccine is what?
A live, attenuated vaccine
Causative agent for strep throat and is usually part of normal microbial flora, commonly found in upper respiratory tract
Stretococcus Pyogens
Streptococcus Pnemoniae causes what?
Pnemonia
drug resistance is common
gram positive, covered in a capsule
causative bacteria agent for whooping cough or kennel cough in dogs
Bordetella Pertussis
Causative bacteria for TB?
Mycobacterium Tuberculosis
Why are TB infections increasing?
Drug resistance
How is TB transmitted?
By airborne droplets
2 types of TB infections
- primary - hypersensitizes patient to bacteria and can be tested with tb skin test
- postprimary - chronic tb resulting in gradual spread of tb lesions in lungs