unit 4 Flashcards
(43 cards)
evolutionary arms race
pathogens influencing the evolution of their hosts and hosts influencing the evolution of pathogens.
types of defenses in immune system
Physical barriers
chemical defenses
cellular defenses
inflammatory response
behavioral
innate immunity
something animals are born with.
Humoral (fluids) innate immunity involves various substances found in body fluids that interfere with pathogen growth or clump pathogens together for easy disposal.
Cellular innate immunity involves cells called phagocytes that “eat” pathogens and by natural killer cells that destroy abnormal body cells.
acquired (adaptive) immunity
recognizes and destroys pathogens that the immune system has encountered before.
This system “learns” to recognize a pathogen’s antigens, such as toxins or proteins the pathogen produces.
Provides a sort of immunologic memory so that the body can fight off a pathogen better in the future.
innate physical defenses
integuments and mucous membranes are the first barrier to invading organisms.
innate chemical defenses
antimicrobial substances that inhibits pathogen growth
Lysozyme attacks the cell wall of many bacteria.
Cytokines are a class of molecules that are used for cell signaling. (They tell neighboring or distant cells to initiate an immune response.)
innate chemical defenses: Antimicrobial peptides AMPs
short chains of amino acids
- Attach to cells and make holes in membranes.
- May also work as cell signaling molecules between host cells.
innate chemical defenses: pattern recognition receptors
proteins on the surface of innate immune cells that detect non-specific antigens
mediate initiation adaptive immunity + inflammatory cytokines
complement system (small proteins in blood)
cleave proteins + release cytokines
activation results in phagocyte attraction/stimulation, inflammation and attack on invader
Cellular Innate defenses: Phagocytosis
A phagocytes is a type a white blood cell
involves invaders, old cells, debris
phago engulfs and lysosomes digest
phago presents receptor for antigens called MHC that activates acquired immune
immunity in invertebrates
xenograft- different species and allograft- same species
inflammation
innate response to pathogens, damaged cells, or irritants.
Involves immune cells (white blood cells), blood vessels, and molecular mediators.
5 cardinal signs of inflammation
Redness, Heat, swelling, pain, loss of function
Inflammation process
starts with immune cells present: phagocytes/white blood cells (macrophages, dendrite, mast)
PRR recognize PAMP, cell activates mediators (histamine, prostaglandin) complementary system is highly active
Inflammation fibrosis
inflammation failed to clear invader, starts walling off site to stop damage
granulomas may surround and suffocate
signs of more severe inflammation
Necrosis, Ascesses, ulcers
Acquired immune response in vertebrates
non self recognition can resist foreign and invader substances
stimulated by Antigen (usually proteins)
made of humoral and cellular immunity (just like innate)
Major Histocompatibility Complex MHC
act like name tags the name being peptide bits
when immune system reads this foreign “name” triggers an attack
recognition molecules
MHC are not the actual receptor just the display
antibodies and T-cells are the molecules
wide variety each with a different antigen receptor
Acquired immunity: lymphocytes
these are white blood cells primary comp
lymphocytes + RBC come from stem cells in bone marrow
Acquired immunity : B cells
B; mature in bone marrow, release in blood/lymph (body fluid)
membrane bound antibodies bind to antigen
memory B cells = copies of original in high concentration
Antibodies : Immunoglobulins
location: surface of B cells or secreted by plasma cells derived from B cells
The amino acid sequence near the ends of the Y varies in both chains bc it forms a cleft, making them specific to an antigen called the antigenic binding site.
Acquired immunity : T cells
T; mature in thymus gland
go through a lot of gene recombination during growth for diversity in receptors
T cells can only recognize antigens that bound to MHC on other cells
Cell mediated v. humoral immunity
Cell-mediated immunity: on the other hand does not depend on antibodies for its adaptive immune functions and is primarily driven by mature T cells, macrophages and the release of cytokines in response to an antigen.
Humoral immunity: produces antigen-specific antibodies and is primarily driven by B cells.