Unit 4 Flashcards
How is the structure of DNA related to function (7)
- Stable due to numerous hydrogen bonds so can be passed on from generation to generation
- Weak hydrogen bonds between strands are easily broken for DNA replication or protein synthesis
- Large so can carry a lot of genetic information
- Base pairs are contained within the helix and held in place by the strong sugar-phosphate backbone
- Complementary base pairs allow the synthesis of an identical daughter molecule
- 2 Strands so both can act as templates
- Helical shape means that it can be coiled so compact for storage
Describe the difference between degenerate and Non-overlapping (2)
Degenerate: More than one base triplet for each amino acid.
Non-overlapping: Each base is part of only 1 triplet
Compare DNA and mRNA (6)
- DNA is double stranded, mRNA is single stranded
- DNA is long, mRNA is short
- Thymine in DNA, Uracil in mRNA
- Deoxyribose in DNA, Ribose in mRNA
- DNA has base pairing, mRNA does not
- DNA has introns, mRNA doesn’t
Comparing mRNA and tRNA (3)
- mRNA is longer
- mRNA is a straight but tRNA is a folded molecule
- mRNA contains hydrogen bonds but tRNA has hydrogen bonds
Which two molecules are ribosomes made from? (2)
- One of RNA
- One of protein
Define the term exon?
Base sequence coding for polypeptide
Name the proteins associated with DNA
Histone
Differences between Eukaryotic DNA and Prokaryotic DNA (5)
- Associated with Histones v No Histones
- Linear v Circular
- No plasmids v plasmids
- Introns v No introns
- Longer v Shorter
Describe transcription (7)
- DNA strands separate by breaking hydrogen bonds
- Only one of the strands is used as a template
- Complementary base pairing, so A to U, A to T, C to G
- Nucleotides joined by RNA polymerase
- Forms phosphodiester bonds
- Pre-mRNA formed
- Splicing to form mRNA
Describe Translation (7)
- mRNA binds to ribosome
- Ribosome moves to start codon
- Idea of two codons
- tRNA with anticodons bind to codon on mRNA
- tRNA brings specific amino acid
- mRNA moves along to the next door
- Formation of peptide bond between amino acids
Role of Ribosome in Translation (5)
- mRNA binds to ribosome
- Idea of two codons
- tRNA with anticodons bind
- Formation of peptide bond between amino acids
- Moves along mRNA to next codon
Role of tRNA in Translation (4)
- Anticodon complementary to codon
- Specific amino acid
- Carried to ribosome
- Correct sequence of amino acids along polypeptide
Describe how a phosphodiester bond is formed between two nucleotides within a DNA molecule
- Condensation reaction
- Between phosphate and deoxyribose
- Catalysed by DNA Polymerase
What is a gene
A sequence of DNA nucleotides that codes for a polypeptide
The genome is…
Complete set of genes in a cell
The proteome is…
The full range of different proteins that a cell is able to produce
Causes of Variation in Meiosis (6)
- Homologous chromosomes pair up
- Chiasmata formed
- Independent segregation
- Maternal and paternal chromosomes are re-shuffled in any combination
- Crossing over leads to exchange of parts of chromatids
- Both create new combinations of alleles
Process of Crossing Over in Meiosis (4)
- Homologous pairs of chromosomes associate
- Chiasmata form
- Lengths of chromatids are exchanged
- Producing new combinations of alleles
Describe how the process of meiosis results in haploid cells
- DNA replication creates two identical chromatids
- Two nuclear divisions
- Homologous pairs separated
- Sister chromatids separated
Define Mutation
A change in the base sequence of DNA, results in a new allele