Unit 3: Cholecystitis Flashcards
Biliary System
- includes the gallbladder and bile ducts
- the cystic duct (from the gallbladder) and the hepatic duct (from the liver) join to form the common bile duct
- primary function: transport bile from the liver, where it is produced, to the gallbladder, where it is stored, and then to the duodenum, where it aids in the digestion of fats
Primary Function of the Biliary System
transport bile from the liver (where it is produced), to the gallbladder (where it is stored), and then to the duodenum (aids in the digestion of fats)
Bile
- digestive enzyme
- helps break down fats
When does biliary Disease occur?
when the gallbladder or ducts become inflamed, infected, or cancerous, impairing the ability of the gallbladder to function normally
Cholecystitis
inflammation of the gallbladder caused by an obstruction of bile flow
- calculous cholecystitis (presence of gallstones)
- acalculous cholecystitis (without stones)
Gallstones
(cholelithiasis)
hard deposits formed from bile contents that often cause obstruction of ducts in and around the gallbladder
-vary in size
-can have single or multiple stones
S/S associated w/ Gallstones: Five F’s
- Fair
- Fat
- Female
- Fertile
- Over Forty years of age
Risk Factors For Gallstones
- obesity
- rapid weight loss
- weight-loss surgery
- eating large amounts of food with saturated fats
- pregnancy (b/c of elevated progesterone)
- genetics
- medications (estrogen, octreotide, and cholesterol-lowering meds)
3 Categories of Gallstones
- Cholesterol stones (most common)
- Pigmented (formed from excess Bilirubin)
- Mixed (combination of both types)
Acalculous Cholecystitis
- w/o stones
- associated with biliary stasis
- there is a slowing or stopping of the flow of bile either from decreased contractility of the gallbladder or spasms in the sphincter of Oddi
Clinical Manifestations of Acute Cholecystitis
-ranges from no physical findings to pain and tenderness in the RUQ, sometimes w/ rebound tenderness or guarding, fever, and tachycardia
The Pain associated with Cholecystitis is d/t?
the release of cholecystokinin, which causes the gallbladder to contract
- pain described as colicky, which is intermittent and radiating to the back, and is r/t the movement of the gallstones through the bile ducts as the bile flows
- there are several small valves in the ducts, and the colicky pain is due to the movement of stones through these areas
- radiation to the back is r/t the innervations of the gallbladder
- have palpable fullness in RUQ, and exhibit a positive Murphy’s sign
Murphy’s Sign
pain on palpation of the RUQ upon deep inspiration
- examiners fingers are placed on the RUQ of the abdomen, and then the examiner gently presses down while asking the patient to take a deep breath
- test is positive if the patient has pain upon deep inspiration
Causes of Acalculous Cholecystitis
- Abdominal surgery
- Severe trauma
- Long-term IV nutrition (> 1 month)
- Prolonged fasting
- Sickle cell disease
- Diabetes Mellitus
- Endotoxin
- AIDS
- Salmonella infection
- Cytomegalovirus
Diagnostic Tests
-Abdominal X-ray
-Abdominal Ultrasonography
-Computed tomography (CT)
-Hepatobiliary iminodiacetic acid (HIDA) scan
-Endoscopic Retrograde Cholangiopancreatography (ERCP)
-Cholecystography
-Cholangiogram
>Others: CBC and liver function tests
Diagnostic Test: Abdominal X-ray
used to detect calcified gallstones
Diagnostic Test: Abdominal Ultrasonography
- noninvasive
- determines presence of gallstones and acute cholecystitis
- a thickened gallbladder is indicative of cholecystitis
Diagnostic Test: CT scan
- visualizes entire abdomen
- can detect presence of gallstones
Hepatobiliary Iminodiacetic Acid (HIDA) Scan
- nuclear medicine scan
- uses a radioactive tracer to study the production and flow of bile, visualizing the liver, gallbladder, bile ducts, and small intestine
Endoscopic Retrograde Cholangiopancreatography (ERCP)
- allows visualization of the common bile duct where gallstones can be removed
- a percutaneous drain can be placed in patients with acalculous cholecystitis who are a high operative risk
- NPO night before procedure; can take their cardiac and BP meds the morning of w/ a small amount of water
- sedated; need to have someone drive them home
- after procedure, goes to PACU to allow time for recovery from the sedation
- nurse observes the patient for a potential systemic inflammatory response syndrome (SIRS) caused by the manipulation of the bile ducts and potential bacterial translocation
Cholecystography
- rarely used
- radiographic test of the gallbladder after the patient orally takes radiopaque dye, which collects in the gallbladder and is excreted by the liver
Cholangiogram
- used in the OR to image the biliary tree
- a radiopaque dye, usually containing iodine, is injected intravenously, which outlines the bile ducts and gallstones
Findings Associated with CBC and Liver Function Tests
- Elevated WBC due to inflammation
- Elevated liver enzymes: AST, ALT, Lactate dehydrogenase (LDH), Alkaline phosphate (ALP) and Bilirubin (b/c of blockage of bile flow in bile ducts)
Treatment of Gallstones
extracorporeal shock wave therapy or lithotripsy to dissolve gallstones
Extracorporeal Shock Wave Therapy
patients sit in a tub of water, and high-energy sound shock waves were directed through the water toward the stones to break them up into smaller pieces that would then pass through the bile duct
Lithotripsy
- used for treatment of small gallstones
- helps dissolve gallstones
Treatment of Acute Cholecystitis
- NPO; to prevent release of cholecystokinin, which is activated when eating and causes the gallbladder to contract and release bile, which leads to pain
- Narcotics (meperidine [Demerol]) used for severe pain management
- Acetaminophen or nonsteroidal medication (ibuprofen) used for less severe pain
- Morphine contraindicated
- IV hydration
- Correction of electrolyte and fluid imbalances
- Pain management
- IV antibiotics as indicated
Oral Agents Used to Dissolve Gallstones
> Ursodiol
Actigall
Chenodiol
-natural bile acids; provided to reduce the size and number of gallstones
-drawback: need to take for up to 2 years; expensive; if patient stops, the stones reappear
-patients may be noncompliant b/c of prolonged treatment