Unit 3 Ch 12 Host Defenses 1 Flashcards

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1
Q

An infection in which the disease symptoms are influenced by more than one colonizer is termed an ___________ infection.

A

Polymicrobial

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2
Q

The total of all microbes found on and in a normal human is referred to as the human _________

A

Microbiome; biota

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3
Q

Organisms coming from somewhere in the same human host are considered _____________.
(Becoming established, Portals of Entry: To initiate an infection, a microbe entrees the tissue of the body by characteristic route, the portal of entry. Usually the skin or a mucous membrane.

A

Endogenous
Organisms coming from the outside of the body are exogenous.

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4
Q

Inflammation;
Disease;
Infection;
Pathology;
____________ can be characterized as any deviation from the healthy state.

A

Disease

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5
Q

A pathogen is a microbe whose relationship with its host is ____________ and results in infection and ________________.

A

Parasitic; disease

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6
Q

Exogenous microbes are likely to first encounter resistance from white blood cells that engulf and destroy pathogens by means of enzymes and antimicrobial chemicals.
These white blood cells are called: ___________

A

Phagocytes.

These cells ordinarily engulf and destroy pathogens by means of enzymes and antimicrobial chemicals

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7
Q

An infection in which the disease symptoms are influenced by more than one microbe is called a(n) ______________ infection.

A

POLYMICROBIAL; MIXED
The majority of infections are Polymicrobial, with contributions from more than one microbe, like the influenza cased by a virus and pneumonia (often caused by a bacterium). Influenza infection frequently leads to pneumonia.
- several types of skin infections are known to be caused by either Staphylococcus or Streptococcus species. When these 2 cultivated together with another common skin resident, MOraxella, both staph and strep increase their transcription of virulence factors. It is possible that the 3 of them together led to the disease symptoms.

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8
Q

Infection with a member of the normal biota, rather than an agent from the outside environment, is an example of an ______________ infection.

A

Endogenous infection

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9
Q

The 1st & 2nd lines of host defense are specific or nonspecific protections?

A

Nonspecific. Do not depend on specific acquisition.

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10
Q

Communication between separate fluid compartments of the body is conducted primarily through _____?

A

CAPILLARIES

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11
Q

A network of fibers & macrophages that permeates the tissues of the body is called the ____ ____ system.

MPS

A

Mononuclear Phagocyte System

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12
Q

Because it provides a passageway within & between tissues & organs, the ____ ____ system is intrinsic to the functions of the immune system.

MPS

A

Mononuclear phagocyte system

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13
Q

A compartmentalized network of vessels, cells, & protection against foreign materials is the ____ system.

A

Lymphatic

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14
Q

Major functions of the lymphatic system:

A
  1. Provides route for the extracellular fluid to return to the circulatory system proper
  2. drain off system for inflammmatory response
  3. render surveillance, recognition & protection against foreign materials through a system of lymphocytes, phagocytes & antibodies.
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15
Q

List the lymphoid organs

A

Spleen, Lymph nodes, Thymus

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16
Q

the flow of lymph goes what direction? Heart to extremities, or extremities to the heart?

A

from the extremities to the heart

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17
Q

Which cell types are produced in the red bone marrow?

A

Red blood cels, B-lymphocyte precursors, T-lymphocyte precursors

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18
Q

Although all blood cells originate in the bone marrow, only the ___ complete their maturation process here.

A

B-lymphocytes

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19
Q

Where T lymphocytes complete their maturation?

A

T lymphocytes migrate to the thymus to complete their maturation. Triangular structure two lobes in the lower neck region

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20
Q

List the major lymph nodes sites in the body.

3

A
  1. Armpit
  2. neck
  3. groin
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21
Q

Where are INGUINAL lymph nodes located?

A

groin

22
Q

What are the lymph nodes located in the armpits called?

A

axillary nodes

23
Q

define: Hematopoiesis

A

the process by which all blood cells are formed in bone marrow.

24
Q

Define HEMOSTASIS

A

the plugging of broken blood vessels to stop bleading.

25
Q

define HOMEOSTASIS

A

The maintenance of a stable internal environment

26
Q

Generalized lymph node enlargement may indicate:
an allergic reaction, or a systemic illness, or a localized infection?

A

a systemic illness

27
Q

B & T cells belong to a group of leukocytes called:
granulocytes, lyphocytes or monocytes?

A

Lymphocytes

28
Q

What is the function of the SPLEEN?

A

filter old blood, removing worn out red cells from circulation.

29
Q

Produced in the bone marrow, the cells are able to become any type of blood cell that is needed.

A

Pluripotential stem cells

30
Q

Leukocytes (WBC) can be divided into 2 categories according to their staining patterns

A
  1. granulocytes: have dark staining granules
  2. agranulocytes: do not have granules, & have large nuclei.
31
Q

true or false?

Monocytes & lymphocytes can be described as agranulocytes.

A

true. a type of leukocyte (wbc)

32
Q

a phagocytic cell that has a high capacity for killing microbes & cleaning up dead cells:
lymphocyte, macrophage, eosinophil or mast cell?

A

macrophage

33
Q

List 3 granulocytic white blood cells

A

eosinophils, basophils, neutrophils

34
Q

Which leukocytes are involved in immunologic responses to fungal and helminth worm infections, allergy & inflammatory reactions.

A

Eosinophils,
a type of granulocyte

35
Q

What are erythrocytes?

A

Red blood cells

36
Q

What is the type of leukocyte, that are motile granulocytic cells that function in inflammatory events and allergies.

A

Basophils

37
Q

Which one is the most common leukocyte and also a phagocyte?

Primary component of pus

A

Neutrophils

38
Q

… are nonmotile cells htat are bound to connective tissue along capillaries. They release mediators such as histamine that trigger local inflammatory reactions & many allergic symptoms.

A

Mast cells

39
Q

A group of leukocytes that include B, Natural Killer, & T cells?

A

Lymphocytes

40
Q

A liquid connective tissue consisting of erythrocytes, leukocytes & platelets suspended in plasma is called:

lymphatic system

A

whole blood

41
Q

wbc

The largest phagocytic white blood cell derived from a monocyte which is involved with specific immune reactions is called a tissue…..

A

macrophage

42
Q

1st line of defense

A host barrier with an acidic pH & high fatty acid content that is inhibitory to many microbes is the ….

A

skin

43
Q

What are the 4 mechanisms that play important roles in host defenses?

A
  1. phagocytosis
  2. inflammation
  3. fever
  4. antimicrobial producs
44
Q

Identify the 3 main types of phagocytes:

neutrophils, dendritic cells, basophils, eosinophils, macrophages

A

neturophils, dendritic cells, macrophages

45
Q

2nd line of defense

which of the following processes are components of the 2nd line of defense:
inflammation, fever, apoptosis, phagocytosis, antimicrobial proteins, sneezing, antibodies

A

Inflammation, Fever, Phagocytosis, Antimicrobial proteins

46
Q

Small proteins naturally produced by white blood cells & tissue cells in response to viral infection are called:

complement proteins, pyrogens, or interferons?

A

Interferons IFN

47
Q

What term describes the migration of white blood cells from the blood vessels into the tissue?

inflammation, chemotaxis, diapedesis, diffusion

A

Diapedesis

48
Q

Phagocytosis 1.

Inflammation signals cause cells to migrate to the area

A

chemotaxis

49
Q

Phagocytosis 2.

pattern recognition receptors identify and stick to foreign cells

A

Adhesion
(PAMs)

pathogen associated molecular patterns - red flags

50
Q

What molecule is found on the surface of microbes & serves as a red flag to phagocytotic cells?
CAMP; ADP, PAMP, FERG?

A

PAMP
Pathogen Associated Molecular Patterns

51
Q

List the 6 steps of Phagocytosis briefly

A
  1. Chemotaxis
  2. Adhesion
  3. Engulfment & phagosome formation
  4. Phagolysosome formation
  5. Destruction
  6. Elimination
52
Q

What term describes a small molecule secreted by cells to regulate & control immunity & inflammation?

Sebaceous secretions, messenger, cytokine, endotoxin?

A

Cytokine