Unit 3 - 3.8-3.11 Flashcards
Characterized by infiltration of mononuclear cells, usually accompanied by fibroplasia, and occurs when the acute inflammatory reaction does not resolve the original injury:
Chronic inflammation
What are the purposes of fibroplasia?
- walls off
- inflammatory cells (creation of small vessels)
What is the typical fate of fibroplasia?
collagen content increase, fibrous tissues matures and contracts
If there is significant fibrosis, the surface of the chronic inflammation will be:
pitted
Why can chronic inflammation be nodular?
presence of abscesses or granulomas
What’s the general colorization of chronic inflammation?
grey to white and firm
What does the type of chronic inflammation depend on me?
- location in body
- infected vs aseptic
Collection of pus in a newly formed cavity usually due to bacteria
abscess
What types of cells help form a wall around the neutrophilic infiltrate after 2-3 days? What is this structure called?
fibroblasts, angioblast
- pyogenic membrane
Why does the inner surface of an abscess produce pus?
provides fresh neutrophils
What is the function of the outer surface of a pyogenic membrane?
barrier to prevent spread
What are the 3 basic fates of an abscess?
- scar
- expands
- empties
Why can an abscess expand?
because bacteria fight back
How does an abscess empty?
into a fistula to another body cavity or to a surface
How can abscess turn into a scar?
bacteria killed, pus resorbed, pyogenic membrane shrinks
spreading of inflammation into the subcutis
cellulitis
spreading of inflammation along parallel tissue planes
phlegmon
the accumulation of pus in a pre-existing cavity such as the pleural cavity
empyema
What type of cell predominates in granulomatous inflammation?
macrophages
A response to indigestible, poorly degradable or persistent antigenic agents
granulomatous inflammation
How do multinucleated giant cells form?
fusion of macrophages
Diffuse infiltrate of macrophages and.or multinucleated giant cells and accompanied by other inflammatory cells, especially lymphocytes:
granulomatous inflammation
Large macrophages that resemble epithelial cells and are located in the center of granulomas. Function is only to secrete mediators:
epitheloid macrophages
List the three common subtypes of granulomatous inflammation:
- pyogranulomatous inflammation
- eosinophilic granulomatous inflammation
- caseating granulomas
Neutrophils seen in the center of granulomas
pyogranulomatous inflammation
Eosinophils seen in the center of granulomas:
eosinophilic granulomatous inflammation
granulomas with large central areas of necrosis; suggestive of TB:
caseating granulomas
proliferation of fibrous CT (fibroblasts and angioblasts)
fibroplasia
Chronic inflammation is typically characterized by a combination of:
mononuclear cells and fibroplasia (usually, but not always)
Why can the surface of chronic inflammation appear pitted?
fibrous CT contracts over time
What are some of the contributing factors to the firmness of tissue with chronic inflammation?
- fibrous CT
- sheer number of inflammatory cells
What is fibroplasia also commonly called?
granulation tissue
Part of the healing process in tissues that can’t be completely restored to normal:
fibroplasia
pathologic channel that erodes from an abscess or body cavity into another cavity or to the body surface
fistula
Rounded mass-like aggregates of macrophages; in other words, granulomas are a nodular form of granulomatous inflammation:
nodular granulomas
