Unit 3 - 3.8-3.11

Question 1

Characterized by infiltration of mononuclear cells, usually accompanied by fibroplasia, and occurs when the acute inflammatory reaction does not resolve the original injury:

Answer 1

Chronic inflammation

Question 2

What are the purposes of fibroplasia?

Answer 2

• walls off

- inflammatory cells (creation of small vessels)

Question 3

What is the typical fate of fibroplasia?

Answer 3

collagen content increase, fibrous tissues matures and contracts

Question 4

If there is significant fibrosis, the surface of the chronic inflammation will be:

Answer 4

pitted

Question 5

Why can chronic inflammation be nodular?

Answer 5

presence of abscesses or granulomas

Question 6

What’s the general colorization of chronic inflammation?

Answer 6

grey to white and firm

Question 7

What does the type of chronic inflammation depend on me?

Answer 7

• location in body

- infected vs aseptic

Question 8

Collection of pus in a newly formed cavity usually due to bacteria

Answer 8

abscess

Question 9

What types of cells help form a wall around the neutrophilic infiltrate after 2-3 days? What is this structure called?

Answer 9

fibroblasts, angioblast

- pyogenic membrane

Question 10

Why does the inner surface of an abscess produce pus?

Answer 10

provides fresh neutrophils

Question 11

What is the function of the outer surface of a pyogenic membrane?

Answer 11

barrier to prevent spread

Question 12

What are the 3 basic fates of an abscess?

Answer 12

• scar
• expands
• empties

Question 13

Why can an abscess expand?

Answer 13

because bacteria fight back

Question 14

How does an abscess empty?

Answer 14

into a fistula to another body cavity or to a surface

Question 15

How can abscess turn into a scar?

Answer 15

bacteria killed, pus resorbed, pyogenic membrane shrinks

Question 16

spreading of inflammation into the subcutis

Answer 16

cellulitis

Question 17

spreading of inflammation along parallel tissue planes

Answer 17

phlegmon

Question 18

the accumulation of pus in a pre-existing cavity such as the pleural cavity

Answer 18

empyema

Question 19

What type of cell predominates in granulomatous inflammation?

Answer 19

macrophages

Question 20

A response to indigestible, poorly degradable or persistent antigenic agents

Answer 20

granulomatous inflammation

Question 21

How do multinucleated giant cells form?

Answer 21

fusion of macrophages

Question 22

Diffuse infiltrate of macrophages and.or multinucleated giant cells and accompanied by other inflammatory cells, especially lymphocytes:

Answer 22

granulomatous inflammation

Question 23

Large macrophages that resemble epithelial cells and are located in the center of granulomas. Function is only to secrete mediators:

Answer 23

epitheloid macrophages

Question 24

List the three common subtypes of granulomatous inflammation:

Answer 24

• pyogranulomatous inflammation
• eosinophilic granulomatous inflammation
• caseating granulomas

Question 25

Neutrophils seen in the center of granulomas

Answer 25

pyogranulomatous inflammation

Question 26

Eosinophils seen in the center of granulomas:

Answer 26

eosinophilic granulomatous inflammation

Question 27

granulomas with large central areas of necrosis; suggestive of TB:

Answer 27

caseating granulomas

Question 28

proliferation of fibrous CT (fibroblasts and angioblasts)

Answer 28

fibroplasia

Question 29

Chronic inflammation is typically characterized by a combination of:

Answer 29

mononuclear cells and fibroplasia (usually, but not always)

Question 30

Why can the surface of chronic inflammation appear pitted?

Answer 30

fibrous CT contracts over time

Question 31

What are some of the contributing factors to the firmness of tissue with chronic inflammation?

Answer 31

• fibrous CT

- sheer number of inflammatory cells

Question 32

What is fibroplasia also commonly called?

Answer 32

granulation tissue

Question 33

Part of the healing process in tissues that can’t be completely restored to normal:

Answer 33

fibroplasia

Question 34

pathologic channel that erodes from an abscess or body cavity into another cavity or to the body surface

Answer 34

fistula

Question 35

Rounded mass-like aggregates of macrophages; in other words, granulomas are a nodular form of granulomatous inflammation:

Answer 35

nodular granulomas