UNIT 2: MEDS TO KNOW Flashcards
What pharm. Class is furosemide?
Loop diuretic
What is the MOA of a loop diuretic like furosemide?
Loop diuretics work by acting at the loop of henle in the kidney in order to block sodium and other ions from being reabsorbed, which eventually leads to reduced water reabsorption and fluid loss in the urine.
Most powerful diuretics and fastest acting diuretic acts within 30mins to 1 hour after administration making it good for emergent uses.
What is the purpose of a loop diuretics like furosemide?
Remove excess fluid/diuresis- increase production of urine to remove excess fluid from the body
What are common uses of loop diuretics like furosemide?
- Peripherial edema
- Pulmonary edema
- HTN
- Acities
All of the above are situations of fluid overload which can be removed by removing fluid by the body.
When should you avoid giving diuretics like furosemide?
- In the evening
- keep in mind for order of med admin. If possible give last so that they dont have to use the bathroom while finishing med admin/assessments
What do you want to make sure your patient has easy accsess to when taking a diuretic like furosemide?
Easy bathroom accsess
What should we closely monitor with a patient taking furosemide?
- I&O/Daily weights
- Electrolyte levels
- Report a urine output less than 30ml/min because a poor urine output even after taking a diuretic can be a sign of a more serious issue
What are some adverse effects furosemide?
- Ototoxicity- high dose or administered too quickly. May require dose adjustment.
- Hypokalemia-
- low k+ can lead to life-threatening affects (disrythmias)
- DO NOT give if levels are below 3.5.
- Usually have a k+ protocol.
- Teach patinet to eat foods high in k+
What is the pharm class of Heparin?
Anticoagulant
What is Heparin?
It is an anticoagulant meaning it is given to prevent blood clot formation by thinning the blood. It does not break up exisiting clots rather prevent new ones from forming.
Who is given haparin?
- Patients who are at high risk for developing blood clots like patients with a history of DVTs and PE, storke, Heart attacks.
- Used to flush central lines to prevent blood inside from clotting and blocking assess to the line.
- Used to prevent clotting during long procedures like open heart surgery
Prevents blood clots
What are potential side effects of taking heparin?
- Can cause life- threatening bleeds
- high alert drugs
- Look for s/s of bleeding- hypotension.
- Can lower platelets- Thrombocytopenia (HIT)
- Monitor platelets.
What should we monitor when a patient is taking Heparin?
- PTT
- used to measure how long the blood takes to clot and can be a good tool to tell us how well heparin is working
- Check baseline PTT… when on heparin the level should be 1.5- 2x bigger. meaning it clots 1.5-2x longer to clot…
- Monitor platelets.
- Assess for signs of HIT
- Drop in more than 50% of platelets or platelets under 150k
What do we want our PTT levels to do when a patient is on heparin?
Needs to be 1.5-2x greater than their baseline
What do we do if a patient on heparin has a PTT level is greater than 2?
This patient is at risk for uncontrolled bleeding… stop the heparin and call the provider
What do we do if a patient on heparin has a PTT level less than 1.5
Call the provider for an increase in dose. Anything less than 1.5 the patient is not being anticoagulated sufficently.
What is the antidote for heparin?
Protomin sulfate given IV
What is the pharm class of lisiopril?
Ace inhibitor
What is the MOA of Lisinioprin (ace inhib)
Work by blocking angiotensin converting enzyme (ACE) which blocks the conversion of (inactive form) angiotensiin I to its active counterpart (active form) angiotensin II. Reduced angiotensiin II cause vasodilation, and reduced downstream signaling of aldosterone further reducses blood volume. The overall effect is lowering blood pressure
Note the function of Angiotensin II- constricts blood vessels and increases blood volume… which increases blood vessels– so when lisinopril is taken this function is blocked