unit 2 drug deliverys Flashcards
what does enteral do
absorption via the GI tract
what does Parenteral do
delivered into tissue fluids or blood (ex:
injections, i
local
topical ex eye drops
what are enteric delivery systems
Enteric coated
Suppositories rectal mucosa
Feeding tubes
Sublingua
pros and cons of enteric delivary
Safe
◦ Convenient
◦ Self-administration
◦ Economical
◦ Non-invasive
cons
Slow onset of action
◦ Possible GI irritation
◦ Cannot be given to unconscious/uncooperative
◦ May undergo extensive first pass metabolism
what are the parental drug delivery’s
Intradermal
Subcutaneous
Intramuscular
Intravenous
Inhalation
Transdermal
Transmucosal
pros and cons of parenteral drug delivary
IV route = Rapid action
◦ More predictable action
◦ Ease of administration to uncooperative/unconscious patients
◦ Avoids first pass metabolism
◦ Avoids GI irritation
* Disadvantages
◦ May be painful
◦ May damage nerves or other tissue
◦ More expensive
◦ Less safe
◦ Asepsis must be maintained
what are topical drug delivery’s
Ointment
* Cream
* Gel
* Powder
* Paste
* Mucous membranes
pros and cons of innovative drugs
Improves compliance
◦ Drug stays in the tissue even after lens removal
◦ Continuous drug delivery
◦ Avoids need for drops or surgery
◦ Not very invasive
* Concerns
◦ Cost
◦ Contact lens intolerance
◦ Risk of infection
what does adverse affect mean
potential harmful effect;
- Iatrogenic-
physician induced; an illness caused by the
drug treatment;
Teratogenicity
Causes fetal abnormalities when given
to the pregnant mother
whats a type A reaction
Pharmacologically mediated
◦ the drug impacts the patient by causing a
greater effect than expected
whats a type b reaction
Hypersensitivity a type of allergic reaction
type 1 reaction
IgE mediated immediate reaction
◦ typical allergy type reaction
◦ but can lead to anaphylaxis
type 2
Antibody-drug antigen complexes lead to
cellular destruction.
Type III
Large antibody-antigen complexes form, cause
inflammation and tissue damage.
