Unit 2 - Chapter 4 of Text Flashcards
What are the two types of longevity?
1) Average longevity
2) Maximum longevity
What is average longevity?
- Commonly called average life expectancy and refers to the age at which half of the individuals who are born in a particular year will have died.
- Is affected by genetics and environmental factors
What are increases in longevity due to?
1) Decline in infant mortality
2) Eliminating diseases such as smallpox, polie
3) Decline in number of women who die in childbirth
4) Medical technology
What is maximum longevity?
- The oldest age to which any individual of a species lives.
- Even if we were able to eliminate all diseases, most researchers estimate the limit to be somewhere around 120 years because key body parts, such as the cardiovascular system have limits on how long they’ll last
What factors influence our longevity?
1) Genetics
2) Environmental
3) Ethnicity
4) Gender factors
Interesting facts on longevity
- If your mother lives to at least age 80, roughly 4 years are added to your average longevity
- Children of parents who lived beyond 80 survived about 20 years longer than children whose parents had both died before they were 60
What is the Human Genome Project (2003)?
An international scientific research project with the goal of determining the sequence of chemical base pairs which make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and functional standpoint
What do researchers with the Human Genome Project hope to do with their work?
1) Improve the way medicines work
2) Implant “correcting” genes into people in the hopes that the good genes will reproduce and eventually wipe out the defective genes
What sorts of environmental factors affect the life span?
1) Disease - cardiovascular, Alzheimer’s, smoking, lack of exercise
2) Toxins
3) Lifestyles
4) Social class
Generally, how are environmental factors involved in the life span?
1) Air and water pollution
2) Toxins in fish
3) Bacteria and cancer-causing agents in drinking water
4) Airborne pollutants
What is the negative impact of social class on life span?
1) Reduced access to goods and services, especially medical care
2) Ethnic groups that experience poverty
3) Little or no health insurance
4) Air pollution in crowded cities and unable to afford to move
5) Lead poisoning from old lead pipes
6) No money for a more healthful lifestyle
How do we differentiate between active life expectancy and dependent life expectancy?
- Active life expectancy is living to a healthy old age
- Dependent life expectancy is simply living a long time
- One’s active life expectancy ends at the point when one loses independence or must rely on others for most activities of daily living (cooking, bathing, etc.) The rest of one’s life constitute living in a dependent state
Give an example of how a change in circumstances can significantly alter expected life span
Acquired immunodeficiency syndrome (AIDS) has had a devastating effect on life expectancy in Africa where some countries (Botswana, Namibia, South Africa, and Zimbabwe) average longevity may be reduced by as much as 30 years
What are some ethnic differences in average longevity?
- Ethnic groups do not have the same average longevity at birth
- African Americans’ average longevity at birth is roughly 6.5 years lower for men and about 5 years lower for women than it is for European Americans
- By age 85, African Americans tend to outlife European Americans
- Latinos have higher average life expectancies than European Americans at all ages despite having less access to health care
What are the gender differences in average longevity?
- Women’s average longevity is about 5 years more than men at birth, narrowing to 1 year by age 85
- This is typical of most industrialized countries, but not developing countries
Why did the female advantage in average longevity in the US become apparent only in the early 20th century?
- Fewer women died in childbirth
- Death in childbirth explains the lack of a female advantage in developing countries
- Access to better health care, work and educational opportunities
Are men or women more likely to die from infection or disease?
- Men’s rates of dying from the top 15 causes of death are significantly higher than women’s at nearly every age
- Men are also more susceptible to infectious disease
- Great susceptibility in men of contracting certain fatal disease and genetics
What advantages may women have over men?
- Women have two X chromosomes whereas men have just one
- Men have a higher metabolic rate whereas women have ahigher brain-to-body weight ration
- Women have lower testosterone levels
How do men and women compare with respect to cognitive testing?
- Older men who survive beyond age 90 are the hardies segment of their birth cohort in terms of performance on cognitive tests
- Between ages 65 and 89, women score higher, but beyond 90, men do much better
How does the World Health Organization (WHO) define “health”?
A state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity
How do we define “illness”?
The presence of a physical or mental disease or impairment
What are the 4 reasons why self-report on one’s health status is accurate?
1) Self-rated health captures more aspects of health than other measures
2) Poor self-related health reflects respondents’ belief that they are on a downward trajectory
3) People’s self-ratings affect their health outcomes
4) Self-rated health may actually represent an assessment of people’s internal and external resources that are available to support health
What does research show about self-reporting on health?
- Self-ratings of health are very predictive of future health outcomes
- Self-ratings also tend to be fairly stable over time
Who self-reports better health … men or women?
- Men rated their health worse than women did
- Among the oldest-old, self-rated health is a powerful predictor of mortality across cultures even after socio-economic status and health conditions had been accounted for
What two areas does research on quality of life focus?
1) Quality of life in the context of specific diseases or conditions
2) Quality of life relating to end-of-life issues
What is the SOC model?
The model of selection, optimization, and compensation (SOC) posits that these three fundamental processes of developmental regulation are essential for successful development and aging. Selection, optimization, and compensation are thought to advance the maximization of gains and minimization of losses associated with aging, thus promoting successful development and aging.
What factors determine quality of life?
- Quality of life depends upon a person’s valuation of life, the degree to which a person is attached to his or her present life
- How much one enjoys life, has hope about the future, and finds meaning in everyday events
How does our immune system work?
- How does the immune system differentiate between our cells and invader cells?
- Some mechanism involves recognizing certain substances called antigens on the surface of invading bacteria and cells that have been taken over by viruses
- Once the immune system has learned to recognize the invader, it creates a defence against that invader
How does the defence system work?
- Based on 3 types of cells that form a network of interacting parts:
1) Cell-mediated immunity
2) Humoral immunity based on antibodies
3) Nonspecific immunity
What is the role of cell-mediated immunity?
- Consists of cells originating in the thymus gland or T-lymphocytes
- -* T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface.
What is the role of humoral immunity based on antibodies (B-lymphocytes)?
- A type of lymphocyte that originates in the bone marrow and produces antibodies.
- A precursor of the plasma cell, it is one of the two lymphocytes that play a major role in the body’s immune response. Also called B lymphocytes
What is the role of nonspecific immunity (monocytes and polymorphonuclear neutrophil leukocytes) cells?
A white blood cell, usually neutrophilic, having a nucleus that is divided into lobes connected by strands of chromatin. Also called multinuclear leukocyte.
What are natural killer (NK) cells?
- Special type of lymphocytes that monitor our bodies to prevent tumor growth and are the primary defence against cancer
- Also fight viral infections and parasites
What is the primary job of the T- and B- lymphocytes?
- To defend against malignant (cancerous) cells, viral infection, fungal infection and some bacteria
What are the 5 major types of specialized immunoglobulins (antibodies)?
1) IgA
2) IgD
3) IgE - is involved in allergies and asthma
4) IgG - also called g-globulin, helps fight hepatitis
5) IgM - includes the first responders in the immune system
What are some of the changes in the immune system over the life span?
- Older adults are more susceptible to certain infections and have a much higher risk of cancer
- Older adults immune systems take longer to build up defences against specific diseases, even after an immunization injection
- This is probably caused by the changing balance in T-lymphocytes and may partially explain why odler adults need to be immunized earlier against specific diseases such as influence
- Similarly, B-lymphocytes decrease in functioning
What research is there regarding administering growth hormones to older adults?
Research examining the administration of substances such as growth hormones to older adults to stimulate lymphocyte functioning indicates that some specific lymphocyte functioning returns to normal with treatment and can regenerate the thymus gland, both of which are important in treating individuals with HIV
What is the difference between when an older adult versus a younger adult faces a serious illness?
- Older adults become more prone to serious consequences from illnesses that are easily defeated by younger adults
What happens to the chances of getting leukemia as one ages?
Various forms of leukemia, which are cancers of of the immune cells, increase with age, along with other forms of cancer
What is autoimmunity?
- When the immune system attacks the body itself
- Autoimmunity results from an imbalance of B- and T-lymphocytes, giving rise to autoantibodies and is responsible for several disorers, such as rheumatoid arthritis
What is psychoneuroimmunology?
The study of relations between psychological , neurological, and immunological systems that raise or lower our suceptibility to and ability to recover from disease
What has been the focus of much of the research into psychoneuroimmunology?
- Identifying the psychological triggers that start the process and result in cancer
- Two types of investigations have been conducted:
1) Predicting which healthy older adults are likely to eventually get cancer
2) Predicting those who will live longer after being diagnosed with cancer - Having a positive attitude, support system predicts longer life for middle-aged patients with cancer, but not for older ones
- Social support appears more important for women than men
What are the characteristics of AIDS in older adults?
- An increasing number of older adults have AIDs
- People who contracted HIV during middle age and survived to later life and people who contracted the disease as older adults
- Many physicians do not test older patients for HIV/AIDs
- Older men are at a higher risk for AIDs - the most common risk factor is homosexual or bisexual behaviour
- Older women usually contract AIDs through heterosexual sex with an infected partner
- Older adults may be more susceptible to HIV infection because of the changes in the immune system
What is the prognosis when older adults are diagnoses with AIDs?
Once older adults are diagnosed with AIDs, their lifespan is considerably shorter than the same diagnosis in younger adults
What is the biggest problem in getting older adults to practice prevention re: AIDs?
- Most physicians assume that older people aren’t sexually active, so they don’t discuss HIV and AIDs with their patients
What is an acute disease?
-Conditions that develop over a short period of time and cause a rapid change in health
What is a chronic disease?
- Conditions that last a longer period of time (at least 3 months) and may be accompanied by residual functional impairment that necessitates long-term management
- Examples of chronic diseases are arthritis and diabetes mellitus
Does the rate of acute illnesses increase with age?
- No, the rate of of acute diseases go down whereas the rates of chronic diseases go up
- Older adults have fewer colds than younger adults
- However, when they do get an acute disease, they get sicker and recovery takes longer
What is the rate of deaths from pneumonia and influenza with older adults
Older adults are at more at risk from things like respiratory infection is about the same for younger and older adults, but people over age 65 account for roughly 90% of deaths from pneumonia and influenza