Unit 2: Ch 81, 83

Question 1

What causes Peptic Ulcer Disease (PUD)?

Answer 1

Imbalance between mucosal and aggressive factors

Question 2

What are the defensive factors of Peptic Ulcers?

Answer 2

Mucus
Bicarbonate
Blood flow
Prostaglandins

Question 3

What are the aggressive factors of Peptic Ulcers?

Answer 3

H. Pylori
NSAIDs
Gastric acid
Smoking

Question 4

What are the goals of PUD drug therapy?

Answer 4

alleviate symptoms
promote healing
prevent complications
prevent recurrence

Question 5

What are the classes of Antiulcer drugs?

Answer 5

antibiotics
anti-secretory agents (H2 blockers & PPIs)
Mucosal protectants
Antacids

Question 6

How do Anti-ulcer drugs work?

Answer 6

Eradicate H. Pylori
Reduce gastric acidity
Enhance mucosal defenses

Question 7

What are the drugs that are for H. Pylori associated ulcers?

Answer 7

Antibiotics
Anti-secretory agents

Question 8

Why should a minimum of 2 antibiotics be prescribed for H. Pylori treatment?

Answer 8

To reduce the risk of resistance developing

Question 9

What are the nondrug therapies for PUD?

Answer 9

Changing eating patterns to 5-6 small meals a day
Avoid smoking, NSAIDs, and alcohol

Question 10

What are Histamine-2 Receptor Antagonists (H2 blockers), and how do they work?

Answer 10

1st choice drugs for gastric and duodenal ulcer treatment
It promotes healing by suppressing secretion of gastric acid

Question 11

What should be monitored for pts taking H2 blockers and PPIs?

Answer 11

Kidney damage

Question 12

How does Famotidine work?

Answer 12

blocks histamine 2 receptors in the parietal cells

Question 13

What are the therapeutic uses of Famotidine?

Answer 13

short-term treatment of gastric/duodenal ulcers
Treatment of GERD
OTC- to treat heartburn, indigestion, sour stomach

Question 14

What are Proton Pump Inhibitors (PPIs)?

Answer 14

Most effective drugs for suppressing secretion of gastric acid

Question 15

What are the therapeutic uses of PPIs?

Answer 15

Gastric/duodenal ulcers treatment
GERD treatment

Question 16

How does Omeprazole work?

Answer 16

Inhibits gastric secretion

Question 17

How does Sucralfate work and what is it used to treat?

Answer 17

Coates the inside of the stomach
Treats Acute ulcers

Question 18

How do antacids work?

Answer 18

React with gastric acid to produce neutral salts or salts of low acidity

Question 19

What are some antacid drugs?

Answer 19

Tums
Rolaids

Question 20

What are the classes of Antiulcer drugs?

Answer 20

Reduction of gastric acids
Neutralization of gastric acid
Ulcer protective
Ulcer healing
Anti H. Pylori drugs

Question 21

Which medication is used to promote gastric
ulcer healing by providing a protective barrier?
A. Cimetidine
B. Misoprostol
C. Omeprazole
D. Sucralfate

Answer 21

D.

Question 22

What are antiemetics given for?

Answer 22

Suppress nausea and vomiting

Question 23

What are the different receptors involved in emetic response?

Answer 23

Serotonin
dopamine

Question 24

How does Ondansetron work?

Answer 24

blocks serotonin receptors

Question 25

What are the adverse effects of Ondansetron?

Answer 25

headache diarrhea dizziness prolonged QT wave

Question 26

What is an example of a Benzodiazepine?

Answer 26

Lorazepam

Question 27

What are the primary benefits of taking a Benzodiazepine?

Answer 27

Sedation Suppression of anticipatory emesis Suppression in anxiety symptoms

Question 28

How does Metoclopramide work?

Answer 28

Blocks serotonin and dopamine receptors Increases upper GI motility and suppress emesis

Question 29

What are the adverse effects of Metoclopramide?

Answer 29

sedation diarrhea tardive dyskinesia

Question 30

A patient who is receiving chemotherapy complains of nausea. Which of the following prescribed medications should the nurse administer? A. Ondansetron B. Prochlorperazine C. Metoclopramide D. Promethazine

Answer 30

A