Unit 2

Question 1

Anti-Jo antibodies are characteristically positive in what disorders?

Answer 1

Dermatomyocytis

Question 2

All are true regarding polymyocytis except:
A. MC in females
B. Endomyocele inflammation on biopsy
C. Bilateral proximal muscle weakness
D. Involves skin

Answer 2

Involves skin

Question 3

Gower sign in present in which of the following?

Answer 3

Duchenne muscular dystrophy

Question 4

Trinucleotide CTG repeat expansion play a role in what muscle disease?

Answer 4

Myotonic dystrophy

Question 5

Which is caused by auto-antibody against postsynaptic Ach receptor and NMJ?

Answer 5

Myasthenia gravis

Question 6

Feature of the disease caused by mutation of FGFR3?

Answer 6

Achondroplasia (short extremities)

Question 7

Multiple fractures at birth, blue sclera, and hearing loss

Answer 7

Osteogenesis imperfecta

Question 8

Lab findings in osteomalacia (Ricket’s child form - vitamin D deficiency)

Answer 8

Low Ca, Low P, high PTH, high alkaline phosphatase

Question 9

All prevent osteoporosis except:
A. Thyroxine supplement
B. Stop smoking
C. Exercise
D. Calcium and Vit D supplements

Answer 9

Thyroxin supplement

Question 10

Hypercortisolism may cause

Answer 10

Secondary osteoporosis

Question 11

Tumor of bone associated with (Eric) Gardner’s Syndrome?

Answer 11

Osteoma

Question 12

Benign tumor involved with metaphysis of femur?

Answer 12

Osteochondroma

Question 13

Most common primary bone tumor?

Answer 13

Osteosarcoma

Question 14

Tumor with sunburst appearance?

Answer 14

Osteosarcoma

Question 15

Bone tumor due to malignant proliferation of poorly differentiated cells derived from neuro-ectoderm?

Answer 15

Ewing Sarcoma

Question 16

Which is not osteoarthritis?
A. Arthritis with morning stiffness that improves with activity
B. Buschard and Hebernden’s nodes - DIP and PIP
C. Involves WB joints
D. Progressive degeneration of articular cartilage

Answer 16

Arthritis with morning stiffness that improves with activity

Question 17

Which is not a feature of rheumatoid arthritis?
A. Osteophytes
B. Pannus
C. Symmetrical joint involvement
D. Subluxation of atlanto-axial joint

Answer 17

Osteophytes

Question 18

Felty syndrome is characterized by:

Answer 18

Rheumatoid arthritis, splenomegaly, neutropenia

Question 19

Rheumatoid factor is an IgM auto-antibody against

Answer 19

Fc portion of IgG

Question 20

10 year old girl, salmon skin rash, polyarthritis, fever, lymphadenopathy. Lab include high WBC, rheumatoid factor negative

Answer 20

Still’s disease (JRA)

Question 21

Arthritis, dry eyes, dry mouth, rheumatoid factor and anti-SSA antibody are positive

Answer 21

Sjorgren’s disease

Question 22

Seen with Ankylosing Spondylitis

Answer 22

HLA-B27 association

Question 23

Common cause of septic arthritis

Answer 23

Nisseria ghonorrhea

Question 24

Feature of acute gout

Answer 24

Podagra

Question 25

Confirms dx of gout

Answer 25

Needle shaped crystals in synovial fluid

Question 26

Abnormal positioning of genital tubercle, associated with bladder

Answer 26

Epispadius

Question 27

Condyloma accumulata of penis (causes genital warts of male and female)

Answer 27

HPV 6 and 11

Question 28

Cryptochyidism increases risk for:

Answer 28

Seminoma

Question 29

Osteoid osteoma small benign bone tumor associated with pain disproportionate to size of lesion:

Answer 29

Pain is caused by excess of prostaglandin E2

Question 30

Besides testes, which structures are involved with mumps?

Answer 30

Parotid gland

Question 31

Seminomas metastasize to:

Answer 31

Para-aortic lymph nodes

Question 32

5 year survival right for seminoma?

Answer 32

Excellent

Question 33

Schiller Deval bodies are associated with?

Answer 33

Yolk sac tumor

Question 34

22 year old male has enlarged testes and gynocomastia. Tumor is made of sytotrophoblastic and synschitothrophoblasts. Surround blood and necrotic tissue. Blood has elevated levels of:

Answer 34

HCG

Question 35

Most common cause of testicular mass in males older than 60

Answer 35

Lymphoma

Question 36

Most common cause of acute prostatitis in 25 year old males

Answer 36

Chylamidia trachamatis

Question 37

Hyperplasia in Benign Prostatic Hypertrophy occurs in what part of prostate gland?

Answer 37

Periurethral zone

Question 38

Risk factor for development of prostate cancer

Answer 38

Black race

Question 39

Confimatory dx for adenocarcinoma of prostate

Answer 39

Biopsy

Question 40

Most common extranodal site for metastasis of prostate cancer

Answer 40

Bone

Question 41

Rhomboid-shaped crystals

Answer 41

Psuedogout

Question 42

Woman is pregnant, notices short limbs on ultrasound. Problem?

Answer 42

Type 1 collagen

Question 43

Osteosarcoma commonly metastasizes where?

Answer 43

Lungs

Question 44

Young boy comes in, has problems with tumor in diaphysis, lots of small, round cells:

Answer 44

Ewing Sarcoma

Question 45

HLA-B27 is associated with all the following except?
A. Osteoarthritis
B. RA
C. Psoriatic Arthritis
D. None of the above

Answer 45

Osteoarthritis

Question 46

Old guy comes in, has had increasing pain over the last few years, notice narrowing margins on x-ray (image of hip). What is it?

Answer 46

Osteoarthritis

Question 47

Guy comes in, issues with 1st MTP joint, needle-shaped crystals in synovial fluid. What lab would be elevated?

Answer 47

Hyperuricemia

Question 48

Guy has all this stuff, has tan homogeneous mass w/o hemorrhage or necrosis. What is it?

Answer 48

Seminoma

Question 49

Guy has elevated alpha-fetoprotein (AFP)…

Answer 49

Yolk sac tumor

Question 50

Tumor of syncytiotrophoblasts/cytotrophoblasts and elevated hCG. What is it?

Answer 50

Choriocarcinoma

Question 51

…prostates…what zone would be most involved in autopsy?

Answer 51

Peripheral