Unit 2 Flashcards
Anti-Jo antibodies are characteristically positive in what disorders?
Dermatomyocytis
All are true regarding polymyocytis except: A. MC in females B. Endomyocele inflammation on biopsy C. Bilateral proximal muscle weakness D. Involves skin
Involves skin
Gower sign in present in which of the following?
Duchenne muscular dystrophy
Trinucleotide CTG repeat expansion play a role in what muscle disease?
Myotonic dystrophy
Which is caused by auto-antibody against postsynaptic Ach receptor and NMJ?
Myasthenia gravis
Feature of the disease caused by mutation of FGFR3?
Achondroplasia (short extremities)
Multiple fractures at birth, blue sclera, and hearing loss
Osteogenesis imperfecta
Lab findings in osteomalacia (Ricket’s child form - vitamin D deficiency)
Low Ca, Low P, high PTH, high alkaline phosphatase
All prevent osteoporosis except: A. Thyroxine supplement B. Stop smoking C. Exercise D. Calcium and Vit D supplements
Thyroxin supplement
Hypercortisolism may cause
Secondary osteoporosis
Tumor of bone associated with (Eric) Gardner’s Syndrome?
Osteoma
Benign tumor involved with metaphysis of femur?
Osteochondroma
Most common primary bone tumor?
Osteosarcoma
Tumor with sunburst appearance?
Osteosarcoma
Bone tumor due to malignant proliferation of poorly differentiated cells derived from neuro-ectoderm?
Ewing Sarcoma
Which is not osteoarthritis?
A. Arthritis with morning stiffness that improves with activity
B. Buschard and Hebernden’s nodes - DIP and PIP
C. Involves WB joints
D. Progressive degeneration of articular cartilage
Arthritis with morning stiffness that improves with activity
Which is not a feature of rheumatoid arthritis? A. Osteophytes B. Pannus C. Symmetrical joint involvement D. Subluxation of atlanto-axial joint
Osteophytes
Felty syndrome is characterized by:
Rheumatoid arthritis, splenomegaly, neutropenia
Rheumatoid factor is an IgM auto-antibody against
Fc portion of IgG
10 year old girl, salmon skin rash, polyarthritis, fever, lymphadenopathy. Lab include high WBC, rheumatoid factor negative
Still’s disease (JRA)
Arthritis, dry eyes, dry mouth, rheumatoid factor and anti-SSA antibody are positive
Sjorgren’s disease
Seen with Ankylosing Spondylitis
HLA-B27 association
Common cause of septic arthritis
Nisseria ghonorrhea
Feature of acute gout
Podagra
Confirms dx of gout
Needle shaped crystals in synovial fluid
Abnormal positioning of genital tubercle, associated with bladder
Epispadius
Condyloma accumulata of penis (causes genital warts of male and female)
HPV 6 and 11
Cryptochyidism increases risk for:
Seminoma
Osteoid osteoma small benign bone tumor associated with pain disproportionate to size of lesion:
Pain is caused by excess of prostaglandin E2
Besides testes, which structures are involved with mumps?
Parotid gland
Seminomas metastasize to:
Para-aortic lymph nodes
5 year survival right for seminoma?
Excellent
Schiller Deval bodies are associated with?
Yolk sac tumor
22 year old male has enlarged testes and gynocomastia. Tumor is made of sytotrophoblastic and synschitothrophoblasts. Surround blood and necrotic tissue. Blood has elevated levels of:
HCG
Most common cause of testicular mass in males older than 60
Lymphoma
Most common cause of acute prostatitis in 25 year old males
Chylamidia trachamatis
Hyperplasia in Benign Prostatic Hypertrophy occurs in what part of prostate gland?
Periurethral zone
Risk factor for development of prostate cancer
Black race
Confimatory dx for adenocarcinoma of prostate
Biopsy
Most common extranodal site for metastasis of prostate cancer
Bone
Rhomboid-shaped crystals
Psuedogout
Woman is pregnant, notices short limbs on ultrasound. Problem?
Type 1 collagen
Osteosarcoma commonly metastasizes where?
Lungs
Young boy comes in, has problems with tumor in diaphysis, lots of small, round cells:
Ewing Sarcoma
HLA-B27 is associated with all the following except? A. Osteoarthritis B. RA C. Psoriatic Arthritis D. None of the above
Osteoarthritis
Old guy comes in, has had increasing pain over the last few years, notice narrowing margins on x-ray (image of hip). What is it?
Osteoarthritis
Guy comes in, issues with 1st MTP joint, needle-shaped crystals in synovial fluid. What lab would be elevated?
Hyperuricemia
Guy has all this stuff, has tan homogeneous mass w/o hemorrhage or necrosis. What is it?
Seminoma
Guy has elevated alpha-fetoprotein (AFP)…
Yolk sac tumor
Tumor of syncytiotrophoblasts/cytotrophoblasts and elevated hCG. What is it?
Choriocarcinoma
…prostates…what zone would be most involved in autopsy?
Peripheral
