unit 1- intro to pharm Flashcards

understand topics and explain them

1
Q

pharmacology

A

the study of how drugs interact with living things.

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2
Q

pharmacognosy

A

the study of the natural origins of drugs

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3
Q

toxicology

A

the dose that makes a drug toxic to the system

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4
Q

in the early beginnings of pharm what was most commonly used?

A

herbal medications

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5
Q

now what are the 4 main sources of drugs?

A

animals, plants, minerals, and synthetics

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6
Q

drug

A

a substance that illicits a biological response when giving to a living organism.

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7
Q

the origin of some drugs determine the proper storage of the drug..t/f

A

true, ex: synthetic insulin must be refrigerated before use

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8
Q

how is a naturally sourced drug made?

A
  1. obtain the natural source
  2. crude drug prep
  3. pure drug compound made
  4. pharmacological prep
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9
Q

what is the crude drug prep?

A

the drug is obtained from the natural source and is made from drying and grinding animal tissue or plant. Then a solvent to extract the natural source ( ex: hot water).

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10
Q

what is a pure drug?

A

a compound isolate from the natural source or made in the lab.

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11
Q

what is Pharm prep?

A

when the drug is intended to give to a pt

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12
Q

what are the different types of names that can be given to a drug?

A
  • Chemical–> formula
  • generic-
  • trade name
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13
Q

what does a chemical drug name tell you and provide an example.

A

provides you with the chemical formula for the drug ex: NaCHCO3

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14
Q

what is does the generic name for a drug mean? example?

A

generic name is the non proprietary name and is the drug name that is used by HCP. Acetaminophen

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15
Q

what is the trade name for a drug mean? example?

A

the proprietary “brand name” of a drug ex Tylenol

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16
Q

what are the different categories of drugs?

A

prescription, non-prescription, and controlled substances

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17
Q

what are prescription drugs and how are they regulated?

A

drugs that have a higher potential for harmful use. Regulated by a healthcare professional

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18
Q

What are non-prescription drugs?

A

Drugs that the FDA decided to be relatively safe and are sold over the counter. dose not require supervision

19
Q

What are controlled drugs and how are they regulated?

A

Drugs that have the highest likelihood of misuse and dependency. Given out by HCP, regulated by Controlled drugs and substances act ( CDSA) and Narcotic control act.

20
Q

what do the CDSA and NCA control?

A

import, production, export, distribution, possession, and availability in the illicit market

21
Q

who regulates the CDSA and what does the CDSA do?

A

Drug Strategy control substances Program ( dscsp)
- decideds what drugs need prescriptions and develops a schedules for where and how they can be sold

22
Q

What is NAPRA and what does it do?

A

National association of pharmacy regulatory authorities. decided drug schedules, the need for rx, supervison of practitioners, and the
uncertainty drugs harm to living organisms,

23
Q

What are the different routes for administration?

A

Enteral or parenteral routes

24
Q

what is the enteral route?

A

oral or rectal routes or buccal/sublingual ( could be parenteral).
drugs undergo first pass at the liver

25
what does the enteric coating on oral medications do?
a layer of polymer that prevents the drug from being broken down by gastric juices in the stomach.
26
which route it the most common for drugs?
Oral tablets (enteric)
27
what is the parenteral route?
drugs that are entered in the blood. ex: IV, IM, SC
28
what are some uncommon parenteral routes?
intrathecal ( in CSF) , epidural ( space above dural membrane in spine), Intra articular ( in joints) etc.
29
what are some pros and cons for the oral route?
- easy/relatively safe disadvantage: - drugs can be inactivated by gastric acids, undergoes first pass
30
what a re some pros and cons of the IM route?
- good for lipid solutions, slow and sustained suspension of drugs or can be rapid cons: painful and can cause bleeding if pt on anticoagulants
31
Subq pros and cons
pro: good suspension, slower absorption cons: some drugs can irritate subq, must be given in larger vols -
32
IV pros and cons
pros: bypasses absorption and givens immediate effect, 100% bioavailability cons: more risk for toxicity
33
what are the general principles of of drugs?
entry, circulation of drug, site of affect, what are the effects, how is it broken down?, removal?
34
what are the properties of medications?
Mechanism of action, indications, adverse effect, contraindications, and toxicity
35
how To receptor interactions occur?
drug goes to site affect and binds to receptor to illicit physiological response.
36
what occurs during absorption of a drug?
drug is transported from site of admin to the bloodstream.
37
what can affect drug absorption?
dose/ concentration, route, blood flow to the site of administration, drug solubility, etc.
38
dose
amount of drug given
39
dosage
how frequent the dose should be given.
40
what dose the dose response relationship show?
as the dose increases the physiological effect increases too
41
What is the therapeutic index
ratio between the toxic dose of drug and the dose that produces a therapeutic effect
42
the space in between desired effect of drug and toxicity?
Margin of safety
43
how is therapeutic index calculated?
TD50/ED50 - measures the toxic affects from a dose in 50% of test population : the 50% that experience therapy response
44
a higher the TI= the safer drug.... t/f
true