Unit 1: Intro & Biomolecules Flashcards

1
Q

Homeostasis is:

A

dynamic constancy of the internal environment

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2
Q

maintenance of _____________ is the key role of physiological systems.

A

homeostasis

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3
Q

Negative Feedback is

A

the principle mechanism by which homeostasis is maintained

[response opposes change in stimulus]

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3
Q

while anatomy focuses on the structure of body systems, physiology focuses on:

A

the function of body systems [what and how they do things]

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3
Q

What is the core concept of physiology (and healthcare) ?

A

homeostasis

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4
Q

negative feedback is _____ common than positive feedback

A

more

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5
Q

positive feedback

A

response enhances change in stimulus

ex) childbirth- oxytocin enhanced to contract uterus

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6
Q

_______ is anything that occupies space and has mass

A

matter

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7
Q

______ is the ability to do work, to put matter into motion

A

energy

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8
Q

what are the 2 types of energy?

A

potential - stored [needed for energy reserves]

kinetic - motion/movement

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9
Q

the smallest units of matter are:

A

atoms

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10
Q

_____ cannot be broken down by chemical means

A

atoms

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11
Q

Number of ______ determines atom’s identity

A

protons

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12
Q

Covalent bonds

A

equal sharing of electrons

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13
Q

ionic bonds

A

atoms interact by transferring electrons

[ions attract opposites]

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14
Q

anything with a charge is described as

A

polar

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15
Q

hydrogen bonds are easily

A

formed and broken

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16
Q

2 types of chemical reactions are

A

synthesis- bonds formed

decomposition- bonds broken

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17
Q

waters, salts, acids, bases, and buffers[usually] are all:

A

inorganic compounds

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18
Q

carbs, lipids, proteins, and nucleic acids are all:

A

organic compounds

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19
Q

the most prevalent inorganic molecular compound in living systems is

A

water

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20
Q

salts form ____ in water

A

ions

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21
Q

acids result in _____ hydrogen ions

A

more

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22
Q

bases result in ____ hydrogen ions

A

less

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23
Q

the building blocks [monomers] of proteins are

A

Amino acids

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24
Q

There are about ____ amino acids

A

20

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25
Q

primary structure determines:

A

identity- shape and function of protein

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26
Q

monomers of nucleic acids are

A

nucleotides

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27
Q

Nucleotides, at their core, are

A

sugar molecules with attached nitrogen base [base gives identity] + attached to a phosphate

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28
Q

mechanism is

A

the “how” of a system

-examines process

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29
Q

where is the intracellular fluid compartment?
Examples?

A

what’s inside the cells
cells that make up the boundary and blood vessels

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30
Q

Where is the extracellular fluid compartment?
Examples?

A

watery internal environment that surrounds cells

serves as the transition between organism’s external environment and intracellular fluid inside cells

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31
Q

Describe the sudivisions of the extracellular compartment

A

everything internal to the body but not enclosed inside blood vessels= interstitial fluid- what all cells are exposed to [tissue fluid]

plasma- inside blood vessels [blood cells]

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32
Q

where do you find interstitial fluid?
Alternative names for this and the space it defines?

A

found in spaces around cells

AKA intercellular or tissue fluid

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33
Q

Describe primary components of feedback system

A

Stimulus
Sensor
Input signal
Integrating center [proccessing and control]
effector- muscle/gland
output signal
target
response

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34
Q

Provide examples of homeostatically controlled physiological variables

A

heart rate
blood pressure
respiratory rate

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35
Q

Describe a simple single effector control system

A

deviation from set point results in return to set point or does not result in a response

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36
Q

Describe a tonic single effector control system

A

-ONE effector that can have OPPOSITE effects
- regulates physiological parameters in the up-down fashion

ex) - blood pressure (blood vessel constricts or dilates in response to how fast or slow the neuron is firing)

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37
Q

Describe an antagonistic control system

A

uses 2 opposing effectors

ex) regulating body temperature- shivering / sweating

ex) heart rate regulation

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38
Q

Define intrinsic

A

from within, or “autoregulation.”

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39
Q

What is intrinsic regulation?

A

AKA autoregulation/intrinsic control

-refers to a physiological mechanism by which a specific organ/tissue/system within the body maintains its own function or homeostasis without requiring external or central control.

-occurs locally within the tissue or organ itself, allowing it to adapt to changing conditions and ensure its optimal functioning.

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40
Q

Define extrinsic

A

includes elements outside of the effector

regulation system that includes different sensors, regulators, and effectors.

systemic regulation (physiological response) [[shivering/sweating]] or behavioral regulation [[putting on a jacket]]

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41
Q

provide example of extrinsic regulation

A

systemic regulation

ex) heart rate regulation mediated by NS (integrator), in response to inputs from body’s sensory receptors

shivering (physiological) or putting on more clothes (behavioral)

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42
Q

afferent

A

Afferent neurons carry information from sensory receptors found all over the body towards the central nervous system

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43
Q

cytology

A

studies the structure, function, and behavior of cells.

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44
Q

efferent

A

efferent neurons carry motor information away from the central nervous system to the muscles and glands of the body in order to initiate an action.

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45
Q

histology

A

the study of the microscopic structure of tissues.

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46
Q

pathology

A

study of disease

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47
Q

pathophysiology

A

the study of body functions in a disease state

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48
Q

pharmacology

A

study of the effects of drugs and chemicals on living organisms

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49
Q

thinking about a physiological event in terms of its adaptive significance is the __________________________ to science

A

teleological approach

[explains WHY not how]

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50
Q

physiology is the study of the

A

normal functioning of a living organism and its component parts, including all its chemical and physical processes

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51
Q

Which of the following is part of the extracellular compartment?

interstitial fluid
cytosol
plasma
nucleoplasm
cytoplasm

A

interstitial fluid
plasma

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52
Q

Negative feedback is a common form of maintaining homeostasis. Negative feedback _______________ changes to the internal environment

A

opposes

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53
Q

Physiology is the study of:

A

the mechanism of function of living organisms

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53
Q

Positive feedback systems work by ____________ deviations from set point.

A

amplifying

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54
Q

The molecular category associated with minimizing changes in ph is:

A

buffers

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55
Q

Bonds that form when electrons are shared between atoms include:

A

polar covalent & covalent bonds

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56
Q

If a substance has a pH that is less than 7, it is considered:

A

acidic

57
Q

The interaction between water molecules that are responsible for the surface tension of water:

A

hydrogen bonds

58
Q

All of the following molecular categories exhibit the ability to polymerize EXCEPT:

carbohydrates
proteins
nucleic acids
lipids

A

lipids

59
Q

The unique functional properties of a protein is due to the proteins _______

A

3d shape

60
Q

_______ are made of non-polar, hydrophobic molecules

A

lipids

61
Q

the interior of any hollow organ is called:

A

its lumen

62
Q

cell membranes consist of microscopic
_____________________ with protein molecules inserted in them

A

bi-layers of phospholipids

63
Q

What are the functions of the cell membrane?

A

-physical isolation
-regulation of exchange with environment
-communication between cell & environment
-structural support

64
Q

neural control is very specific because each neuron has a:

A

specific target cell(s) to which it sends its message

65
Q

the nervous system uses both ________ and _______ signals to send info throughout the body

A

electrical and chemical

66
Q

neural reflexes are much ________ than endocrine reflexes

A

faster

67
Q

molecules that contain carbon are known as

A

organic molecules

68
Q

organic molecules associated with living organisms are also called

A

biomolecules

69
Q

The 4 major groups of biomolecules are

A

carbs
lipids
proteins
nucleic acids

70
Q

DNA and RNA are the structural components of

A

genetic material

71
Q

Conjugated proteins

A

protein molecules combined with another kind of biomolecule

ex) lipoproteins; glycoproteins

72
Q

Polymers

A

biomolecules that are large molecules made up on repeating units

73
Q

functional groups

A

combination of elements that occur repeatedly in biological molecules

74
Q

What are the 4 major biological roles of electrons?

A

Covalent bonds- bind atoms together

Ions- basis for electrical signaling in body

High-energy electrons- energy is used for synthesis, movement, and other life processes

Free radicals- unstable molecules that contribute to aging/diseases

75
Q

_________ molecules have positive and negative ends/poles

A

polar

76
Q

A nonpolar molecule is one whose shared electrons are distributed so evenly that there are :

A

no regions of partial positive or negative charge

77
Q

anions are

A

negatively charged ions

78
Q

cations are

A

positively charged ions

79
Q

ionic bonds result from attraction between

A

ions with opposite charges

80
Q

H2O is a good example of a _____ molecule

A

polar

81
Q

a hydrogen bond is a weak attractive force between a __________________ and a nearby oxygen, nitrogen, or fluorine atom

A

hydrogen atom

82
Q

molecules that are soluble in water are said to be

A

hydrophilic

83
Q

molecules such as oils that do not dissolve well in water are said to be

A

hydrophobic

84
Q

a molecule’s shape is closely related to its:

A

function

85
Q

some proteins act as ________: biological catalysts that speed up chemical reactions

A

enzymes

[important for metabolism]

86
Q

proteins that bind signal molecules and initiate cellular responses are called:

A

receptors

87
Q

_________ proteins turn cell processes on and off or up and down

A

regulatory

88
Q

enzymes lower __________ _______ of reaction

A

activation energy

89
Q

________ are the key to cell function

A

proteins

90
Q

The pH scale is specifically a measure of:

A

hydrogen ion concentration

91
Q

______ molecules are non-polar

A

lipid

92
Q

Interactions between atoms are a property of the atoms:

A

electrons

93
Q

In a typical negative feedback system, there are three key components; a sensor, an integrator and effectors.

The _________ detects the amplitude of a stimulus (i.e. speed)

A

sensor

94
Q

the sensor in the feedback system only:

A

detects stimuli

-measures amount of change & relays info by way of afferent pathway to integrator

95
Q

The concentration of a solution expresses the amount of

A

solute per volume of solution

96
Q

The vasodilation of the blood vessels in muscles in response to the muscles production of carbon dioxide during exercise is an example of _______ control

A

local

97
Q

highly soluble biological molecules can also be called a:

A

solute

98
Q

highly soluble biological molecules are very likely to ___________ in water

A

dissolve

99
Q

According to the second law of thermodynamics, all things spontaneously transition from a :

A

high energy state to a low energy state

100
Q

Homeostasis is the ability of the body to:

A

oppose changes to the internal environment

101
Q

Physiological systems often exibit some activity when in the resting state. This allows these systems and associated effectors to increase or decrease their activity as needed in response to a stimulus. The resting level of activity is called:

A

tone

102
Q

All negative feedback systems function by _______ changes in the internal environment.

A

opposing

103
Q

Anabolic hormones have been used by athletes to improve performance. These “steroids” belong to which organic molecule categories:

A

lipid

104
Q

The observed state of dynamic constancy within the “internal environment” is called:

A

homeostasis

105
Q

What are the only two variables that can be quantitatively measured (without modification) by electronic bioinstrumentation like the instruments in lab?

A

voltage
time

106
Q

A pH 3.7 solution would be described as:

A

acidic

107
Q

cells maintain a resting potential as long as ___________________________is unchanged

A

ion permeability and concentration

108
Q

if the cell’s permeability to any ion changes, the potential of the cell will change. This is called:

A

Excitability

109
Q

excitability is due to the controlled opening and closing of ________________

A

ion channels

110
Q

The ___________ is the processing and control center

A

integrator

111
Q

What does the integrator do?

A

takes the info from the sensor and info associated with setpoint and compares them

if different, it will produce a response relayed by efferent pathway to effector

112
Q

The effector is typically a

A

muscle or gland; produces response/effect that adjusts initial stimulus

ex) stimulus is elevation in body temp; response = pull temp back down to correct for change in stimulus [[[negative feedback]]]

113
Q

_____ means there is activity at rest that can be increased or decreased

A

“tone”

114
Q

if there is “tone”, a ________________ system can be more effective

A

single effector

115
Q

our blood vessels exhibit _______ control, which allows them to respond to changes in the internal Co2 levels

A

local

116
Q

electrons

A

~tiny mass
~in motion in orbits
~negative charge
~determine how atoms will interact with other atoms
~electrons can be added or removed = ions

117
Q

neutrons

A

have no charge & change the isotope form of elements

118
Q

atomic number is found

A

on top of the element symbol in the periodic table

119
Q

atomic weight is found

A

under the element symbol in the periodic table

120
Q

endothermic vs exothermic

A

endothermic- heat absorbed

exothermic- heat released

121
Q

endergonic vs exergonic

A

endergonic- requires energy

exergonic- release energy

122
Q

anabolic vs catabolic

A

anabolic- uses energy

catabolic- releases energy

123
Q

Describe the characteristics of water.

A

~broad spectrum, universal solvent
~high heat capacity
~high heat of vaporization
~”sticky” properties (adhesive, cohesive)

124
Q

Describe the characteristics of salts.

A

~dissolve in water
~form ions in waters
-crystalline arrangement
-important role in water composition/distribution/charges

125
Q

Describe the characteristics of acids and bases.

A

Dissociate in water and produce ions

Acids- when placed in water, release hydrogen ions
[proton donor]

Bases- attract and remove hydrogen ions from water
[proton acceptor]

126
Q

Describe the characteristics of buffers.

A

~molecules that resist pH changes
~will absorb and release hydrogen ions
~critical for stabilizing pH

127
Q

Define “monomer” and “polymer”.

A

monomer- molecule that can react together with other monomer molecules to form a larger polymer chain

polymer- many monomers linked together

128
Q

What are the monomers of carbohydrates called?

A

monosaccharides

[basic building block] -smallest molecules that are carbohydrates

129
Q

3 forms of polysaccharides

A

Polysaccharides

1] Starch - made of glucose

2] Glycogen - energy storage for humans [not as efficient as lipids]

3] Cellulose - stable, not digestible; structural; plant cell wall

130
Q

Compare and contrast between triglycerides, phospholipids and steroids.

A

triglycerides- glycerol backbone & positions for 3 fatty acids
~primarily used for energy storage; also important in thermoregulation & padding/protection

phospholipids- glycerol base w/ 2 non-polar fatty acid tails & phosphate group [polar head w/ charge]
~form cell membrane

steroids- common role as cellular signals

131
Q

What are the polymers of proteins called?

A

polypeptides or proteins

132
Q

Describe the different levels of protein structure.

A

Primary- amino acid sequence

Secondary- amino acid sequence folding ~ Alpha helix or pleated sheet

Tertiary- irregular loops/folds; 3d shape ~ polypeptide; ionic and covalent bonds

Quaternary- not all proteins; sometimes individual proteins interact with other proteins of the same time; 3d shape; 2x alpha chain 2x beta chains.

132
Q

What is the significance of hydrogen bonds to protein function?

A

amino acid sequence folding is primarily due to hydrogen bonds

133
Q

What is the general role of protein in living things?

A

~critical as they do all of the work
~any action within a cell is a property of a protein

134
Q

Name & describe two types of nucleic acid polymer

A

DNA- sugar phosphate backbone, nitrogen base; double helix; info bearing molecule; nucleotide sequence convey recipe for amino acid order to form proteins; stores and transfers genetic info

RNA- directly codes for amino acids and as acts as a messenger between DNA and ribosomes to make proteins

135
Q

What is the role of nucleic acids in living things?

A

carry genetic information which is read in cells to make the RNA and proteins by which living things function

136
Q

The mass of an atom is mostly made up of

A

Protons and neutrons

137
Q

first electron shell can hold -
outermost electron shell can hold -

A

2

8

138
Q

polar covalent bonds occur when-

A

electrons are shared, but sharing is unequal,

so electrons are spending more time with one atom

139
Q

________ bonds are formed by attraction between weak charges on polar molecules

A

hydrogen

140
Q

Inorganic compounds do not have atoms of :

A

carbon

141
Q

Organic compounds always have atoms of :

A

carbon

142
Q

organic compounds are products of

A

living things/processes

143
Q

as hydrogen ion levels increase, pH values _________

A

decrease