unit 1: drugs

Question 1

what is Sermorelin

Answer 1

synthetic GHRH used to treat GH def can be administered parenterally

• got discontinued

Question 2

what drugs stim GH release

Answer 2

glucagon, arginine, clonidine and insulin induced hypoglycemia

Question 3

what is Tesamorelin

Answer 3

(novel GHRH analogue)

used in treatment of HIV associated lipodystrophy

Question 4

what is Somatropin

Answer 4

recplacement recombinant human growth hormone

but short half life and very expensive

Question 5

what is mecasermin

Answer 5

effective treatment for patients with GH insensitivity (Lardon dwarf)

Question 6

what is octreotide

Answer 6

Somatostatin receptor ligands (SRLs), inhibt GH secretion

*somatostatin itself is rarely used bc half life is only a few min

Question 7

what is lanreotide?

Answer 7

Somatostatin receptor ligands (SRLs), inhibt GH secretion

*somatostatin itself is rarely used bc half life is only a few min

Question 8

what is pasireotide?

Answer 8

somatostatin analogue first approved to treat Cushings disease but now effective for acromegaly

Question 9

what is pegvisomat?

Answer 9

GH analoge that has been modifed to bind to one site on GH receptor w/ higher affinity than native mol, but other bidnign site it inactive

binds tightly to monomeric GH receptor but prevents dimerization required for activation (acts as competitive antagonist)

*most potent IGF-1 reducing potential, but inc GH levels because of decreased IGF-1 mediated feedback