Ulcerative colitis

Question 1

ulcerative collitis

Answer 1

• inflammation of the most superficial layer of the mucosa and submucosa limited to colon and rectum
• continous inflammatory lesion which progresses from distal to proximal colon

Question 2

Pathophysiology of ulcerative colitis

Answer 2

• autoimmune cytotoxic T cells attack lining of the colon causing ulcers
• high proportion of pANCA antibodies which cross react with neutrophil
• high proportion of sulfide producing gut bacteria

Question 3

riskfactors

Answer 3

1. increased risk of colon cancer -> adenocarcinoma/intestinal lymphoma
2. Cholongiocarcinoma

Question 4

treatment

Answer 4

1. Colectomy - removal of large colon cures the disease as its limited to rectum etc
2. Smoking - a protective factor