Crohn's disease

Question 1

crohn’s disease

Answer 1

transmural inflammation across all layers of the colon occurring in patchy, discontinuous segments called skip lesions anywhere in the GI tract

Question 2

clinical features of crohns disease

Answer 2

1. Bloody, mild diarrhoea - cells damaged unable to reabsorb water
2. Right, lower quadrant pain - periods of active disease and asymptomatic periods
3. Fibrosing structures - particularly terminal ileum, narrowing of the bowel due to scar tissue may cause obstruction
4. Ulcers and fistulae develop
5. Increased risk of developing small bowel cancer
6. GRANULOMAS - characteristix of crohns

Question 3

pathophys of crohn’s disease

Answer 3

1. inflammation is triggered by pathogens in gi tract
2. response is large uncontrolled and dysfunctional
3. collection of inflammatory cells is granulomas
4. causes healthy tissue destruction
   • all layers of GI tracts
   • can occur anywhere in GI tract
   • mainly small intestine/illeocecal area

Question 4

risk factors

Answer 4

• women 14-40 years
• smoking - is common in smoker
• genetics - NOD2 genne defect in epithelial wall makes it less resistant to bacteria entering, more likely to trigger immune response to inflammation

Question 5

treatment of crohns

Answer 5

• antiinflammatory
• antibiotics - gut flora
• resection of affected tissue