Ulcer Drugs

Question 1

List 3 drugs that decreases acid secretion and describe their MOA

Answer 1

1. Cimentidine: H2 receptor (on parietal cells) antagonist
2. Pirenzepine: Muscarinic receptor (on parietal cells) antagonist
3. Omeprazole: Proton pump inhibitor

Question 2

List 2 drugs that acts as an antacid and neutralises the stomach acid

Answer 2

1. Sodium bicarbonate

2. Calcium carbonate

Question 3

List 3 agents that promotes mucosal defence and describe their MOA

Answer 3

1. Sucralfate: releases Al3+ and becomes negatively charged and bind to positively charged glycoprotein on the mucosal wall (acts as a barrier)
2. Bismuth: combines with mucus glycoprotein to form barrier, stimulate secretion of mucus and has direct antimicrobial activity against H. Pylori (so used to Tx of H. Pylori as well)
3. Misoprostol: prostaglandin analogue that promotes mucus production by mucus cells

Question 4

List 4 drugs that can be used to eradicate H. Pylori (aside from Bismuth) and describe their MOA

Answer 4

1. Amoxicillin: inhibit transpeptidase
2. Clarithromycin: binds to 50s subunit of ribosomes
3. Tetracycline: binds to 30s subunit of ribosomes
4. Metronidazole: dirupt DNA helical structure and inhibit DNA synthesis