Parasites drugs

Question 1

Describe 2 types of Protozoa Infections

Answer 1

Amebiasis and Malaira

Question 2

List 3 drugs for amebiasis and describe their MOA

Answer 2

1. Chloroquine: Parasites digest RBC for food but the heme released will kill them. They use Heme polymerase to convert the heme into hemozoin that is non-toxic. Chloroquine inhibits Heme polymerase and the toxic heme is not degraded.
2. Metronidazole: Damage protozoa DNA and inhibit DNA synthesis
3. Iodoquinol: MOA unknown but useful against amebae in intestinal lumen

Question 3

List 4 malaria drugs and describe their MOA

Answer 3

1. Chloroquine
2. Proguanil: dihydrofolate reductase inhibitor
3. Tetracycline: 30s protein
4. Artemisinin: Chi. med, MOA unknown

Question 4

List 3 antihelmintic drugs and describe their MAO

Answer 4

1. Mebendazole: inhibit worm’s ability to absorb glucose
2. Pyrantel: Increase Ca2+ permeability and paralyse parasites
3. Ivermectin: paralysis and death of parasites