Hepatitis drugs

Question 1

List 3 Hepatitis B drugs and describe their MOA

Answer 1

1. Interferon: increase immune response (or Peg-interferon, which is a modified interferon that stay in the body much longer)
2. Entecavir: Guanosine analogue inhibitor
3. Tenofovir : nucleotide analogue reverse transcriptase inhibitor

Question 2

Describe the rationale of Hepatitis C treatment

Answer 2

Suppress the virus to the point where it becomes undetectable and reaches Sustained Virologic Response (SVR) - virus being undetected 6 months after completion of treatment

Question 3

Describe the treatment of Hepatitis C

Answer 3

Peg-interferon and Ribavirin (Guanosine analogue that stop viral RNA synthesis)- effective against ALL genotypes of Hepatitis C virus