Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ISOM > ugh meds, conditions, morphagens, coenzymes > Flashcards

ugh meds, conditions, morphagens, coenzymes Flashcards

1
Q

TPP (thiamine pyrophosphate)

A

oxidative decarboylation, transfers aldehyde group

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CoA-SH

A

acyl transfer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

PLP (pyridoxal phosphate)

A

transamination, deamination , decarboxylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

tetrahydrofolate

A

transfers carbons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

FAD/NAD

A

redox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

morphagen examples

A

gradients

TGF B
BMPs bone morphagen proteins
hedgehot series
wingless related intergration site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

antibiotics and topoisomerase

antibiotic resistence

A

antibiotic target topisomerase stop ligation which causes cell death

point mutations lead to antibiotic resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

topotecan

A

used in chemo

stabilizes topo-1-DNA, prevents religation, no replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

AZT

A

nucleoside analog
used in HIV
it inhibits chain enlogation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

gancyclovir

A

nucleoside anaolog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Adefovir

A

used for hepatitis

nucleotide analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

5-flurouracil

A

base analog

inhibit TS which converts dTMP to dTTP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

competitive inhibitors

A

statins
methotrexate
salicylate COX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

noncompetitive inhibitors

A

cyanide
DJNK 1
nifedipine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

uncompetitive (mixed)

A

pepstatin
trypsin inhibitor
ethanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

irreversible inhibitor

A

aspirin

17
Q

problems with BER

A

werner’s syndrome

18
Q

problems wit MSH2 and MSH1

A

lynch syndrome

colon cancers

19
Q

problems with homologous repair

A

BRCA1/2

20
Q

fribrillin mutation and elastin disease

A

marfan

21
Q

smoking causes a defect in this inflammation protector

A

alpha 1 antitrypsin

22
Q

collagen issue, can’t remove N/C term or cross-link, stretchy skin

A

EDS

23
Q

in collagen gly is replaced with bulky side chains,

also an ex of haploinsuffiency (mild)

A

osteogenesis imperfecta

24
Q

disruption in alpha helices and b sheets, bad protein folding

A

prion disease

25
Q

plyQ expression CAG (gly) causes cell death

A

huntington’s disease

26
Q

ERCC6/8 mutation

A

cockayne syndrome

27
Q

defect in double strand break repair

A

bloom syndrome

28
Q

suspect consanguinity in

A

rare AR diseases

29
Q

examples of incomplete penetrance

A

huntington’s retinoblastoma

30
Q

examples of varied expressivity

A

marfan, CF, polycystic kidney disease

31
Q

examples of delayed age of onset

A

huntington’s, hereditary cancers

32
Q

examples pleitropy

A

marfan, CF

33
Q

examples of locus hetrogeneity

A

retinits pigmentosa, BRCA

34
Q

commonly new mutation not heritary

A

achondroplasia

ISOM (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions