U2: Anti-Platelet Drugs

Question 1

How do anti-platelet drugs function?

Answer 1

They prevent thrombosis by suppressing platelets from clustering in arteries

Question 2

What is the common name for acetylsalicylic acid?

Answer 2

Aspirin

Question 3

What is the brand name for clopidogrel bisulfate?

Answer 3

Plavix

Question 4

What route are acetylsalicylic acid and clopidogrel bisulfate given?

Answer 4

Oral

Question 5

Is it safe to administer anti-platelets and anti-coagulants concurrently?

Answer 5

No.

Question 6

Anti-platelets are contraindicated for:

Answer 6

GI bleeding, intracranial hemorrhage and active bleeding

Question 7

Acetylsalicylic acid works by inhibiting:

Answer 7

COX (cyclooxygenase)

Question 8

Clopidogrel bisulfate works as an antagonist for:

Answer 8

Adenosine diphosphate

Question 9

What are side effects of acetylsalicylic acid?

Answer 9

Abdominal pain, nausea, dyspepsia (indigestion)

Question 10

What are adverse effects of acetylsalicylic acid?

Answer 10

GI bleed, intracranial bleed, hepatic failure.

Question 11

What are contraindications for acetylsalicylic acid?

Answer 11

GI bleeding, intracranial hemorrhage, active bleeding, pregnancy

Question 12

Which antiplatelet is used after MI/stroke to prevent reocurrence?

Answer 12

Clopidogrel bisulfate

Question 13

How many days before surgery should you discontinue acetylsalicylic acid?

Answer 13

7

Question 14

How many days before surgery should you discontinue Clopidogrel bisulfate?

Answer 14

5

Question 15

What dose of acetylsalicylic acid is toxic?

Answer 15

> 300 mcg/mL

Question 16

What is the antidote for acetylsalicylic acid?

Answer 16

Sodium bicarbonate

Question 17

What are the side effects of Clopidogrel bisulfate?

Answer 17

Abdominal pain, dizziness, confusion, headaches, hematoma, diarrhea, constipation, peripheral edema, rash

Question 18

What are adverse reactions of Clopidogrel bisulfate?

Answer 18

Hyper/hypotension, bronchospasm, bleeding, peptic ulcer, intracranial/GI bleeding, agranulocytosis, thrombocytopenia, pancytopenia, hepatic failure, Stevens-Johnson syndrome

Question 19

What are contraindications for Clopidogrel bisulfate?

Answer 19

GI bleed, intracranial hemorrhage, active bleeding