U2: Anti-Platelet Drugs Flashcards
How do anti-platelet drugs function?
They prevent thrombosis by suppressing platelets from clustering in arteries
What is the common name for acetylsalicylic acid?
Aspirin
What is the brand name for clopidogrel bisulfate?
Plavix
What route are acetylsalicylic acid and clopidogrel bisulfate given?
Oral
Is it safe to administer anti-platelets and anti-coagulants concurrently?
No.
Anti-platelets are contraindicated for:
GI bleeding, intracranial hemorrhage and active bleeding
Acetylsalicylic acid works by inhibiting:
COX (cyclooxygenase)
Clopidogrel bisulfate works as an antagonist for:
Adenosine diphosphate
What are side effects of acetylsalicylic acid?
Abdominal pain, nausea, dyspepsia (indigestion)
What are adverse effects of acetylsalicylic acid?
GI bleed, intracranial bleed, hepatic failure.
What are contraindications for acetylsalicylic acid?
GI bleeding, intracranial hemorrhage, active bleeding, pregnancy
Which antiplatelet is used after MI/stroke to prevent reocurrence?
Clopidogrel bisulfate
How many days before surgery should you discontinue acetylsalicylic acid?
7
How many days before surgery should you discontinue Clopidogrel bisulfate?
5
What dose of acetylsalicylic acid is toxic?
> 300 mcg/mL
What is the antidote for acetylsalicylic acid?
Sodium bicarbonate
What are the side effects of Clopidogrel bisulfate?
Abdominal pain, dizziness, confusion, headaches, hematoma, diarrhea, constipation, peripheral edema, rash
What are adverse reactions of Clopidogrel bisulfate?
Hyper/hypotension, bronchospasm, bleeding, peptic ulcer, intracranial/GI bleeding, agranulocytosis, thrombocytopenia, pancytopenia, hepatic failure, Stevens-Johnson syndrome
What are contraindications for Clopidogrel bisulfate?
GI bleed, intracranial hemorrhage, active bleeding
