Tyrer-Cuzick and riskScore

Question 1

The Tyrer-Cuzick risk score will be provided to?

Answer 1

Female Patients
Unaffected with Breast Cancer
Negative for a Breast Cancer related Gene Mutation

Question 2

If a Patient is affected with a cancer other than breast and who are negative for a breast cancer gene mutation will they receive a Tyrer-Cuzick?

Answer 2

YES

Question 3

How will Tyrer-Cuzick be reported on the MMT

Answer 3

Remaining Lifetime Risk estimate and a 5 year risk estimate

Question 4

What does National Comprehensive Cancer Network (NCCN) and American Cancer Society (ACS) recommend to consider if Tyrer-Cuzick is >20%

Answer 4

consider MRI plus Mammogram

Question 5

What are 3 categories of breast cancer risk?

Answer 5

Sporadic (General Pop)
Familial
Hereditary

Question 6

Which model was replaced by Tyrer-Cuzick

Answer 6

Claus Cancer Assessment Tool

Question 7

What does the Tyrer-Cuzick Risk Model incorporate?

Answer 7

Familial Hx
hormonal
pathological factors (biopsy) 
benign disease
age
body mass
Ashkenazi descent 
HRT usage
Incorporates Negative BRCA 1/2 results

Question 8

A woman who has reported a relative that has been diagnosed with a breast cancer related gene mutation will receive a Tyrer-Cuzick estimate?

Answer 8

FALSE

Question 9

Which patients are eligible for a RiskScore calculation?

Answer 9

Under age 85
SOLELY of European ancestry
No personal history of breast cancer
LCIS
hyperplasia or atypical hyperplasia
breast biopsy with unknown results
No mutation in breast cancer gene, or have a FAMILY member with a mutation in a breast cancer related gene

Question 10

Is the RiskScore calculated if no ancestry is selected on TRF?

Answer 10

NO

Question 11

Mutations in which breast cancer related genes would result in riskScore not being run? 11 genes

Answer 11

BRCS 1/2
TP53
PTEN
STK11
CDH1
PALB2
CHEK2
ATM
NBN
BARD1

Question 12

What % of the time is there a Medical Management change with myRisk?

Answer 12

54%