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CANCER > Hereditary Cancer > Flashcards

Hereditary Cancer Flashcards

Statistics and Risk Data

1
Q

What % of BREAST Cancer is due to a mutation?

A

12-14%

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2
Q

What is the annual incidence of BREAST Cancer?

A

255,000

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3
Q

What is the risk of BREAST Cancer with a BRCA

Mutation?

A

up to 87%

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4
Q

What is the risk of a 2nd BREAST cancer with BRCA

mutation?

A

64%

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5
Q

What is the general population risk for BREAST Cancer?

A

12-14%

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6
Q

What % of OVARIAN Cancer is due to a mutation?

A

24%

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7
Q

What is the annual incidence of OVARIAN Cancer?

A

22,000

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8
Q

What is the risk of OVARIAN Cancer with BRCA Mutation?

A

up to 63%

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9
Q

What is the risk of OVARIAN Cancer with Lynch mutation?

A

up to 12%

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10
Q

What is the General Population risk for OVARIAN Cancer?

A

<1%

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11
Q

What % of Uterine/Endometrial Cancer is due to mutation?

A

9%

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12
Q

What is the annual incidence of Uterine Cancer

A

61,000

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13
Q

What is the risk of UTERINE/ENDO Cancer with a Lynch Mutation?

A

up to 71%

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14
Q

What is the General Population Risk for UTERINE/ENDOMETRIAL Cancer?

A

1.5%

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15
Q

What % of COLORECTAL Cancer is due to a gene mutation?

A

10%

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16
Q

What is the annual incidence of COLORECTAL Cancer?

A

135,000

17
Q

What is the risk of COLORECTAL Cancer with a Lynch Mutation?

A

82%

18
Q

How many people have a BRCA1/2 mutation?

A

1 in 400

19
Q

What is the risk of COLORECTAL Cancer with a Colon gene mutation?

A

up to 99%

20
Q

What is the COLORECTAL Cancer risk in the general population?

A

2%

21
Q

What is the risk of 2nd COLORECTAL Cancer with Lynch Mutation?

A

38%

22
Q

How long does it usually take for polyps to become cancerous in the General Population?

A

5-10 years

23
Q

How long does it take for polyps to become cancerous in a patient with LYNCH SYNDROME

A

1-3 years

CANCER (5 decks)

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