Type A Dissection Flashcards

1
Q

What occurs in an aortic dissection?

A

There is an intimal tear allowing blood to go between the medial and intimal layers

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2
Q

What is the Stafford Classification of aortic dissections?

A

Type A = ascending aorta involved; Type B = only descending thoracic aorta and below are involved (may involve the arch though)

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3
Q

What is the mortality rate without surgery with a Type A dissection?

A

1-2% per hour for the first 48 hours; 74% by 2 weeks

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4
Q

How are dissections characterized via timing?

A

Hyperacute = <24 hours, Acute = 1 day to 2 weeks, Subacute = 2 weeks to 3 months, Chronic = > 3 months

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5
Q

What is the incidence rate for acute aortic dissections?

A

3 cases per 100,000 per year

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6
Q

What are risk factors for aortic dissection?

A

Male + connective tissue disorders (Marfan, Ehlers-Danlos, Loeys-Dietz) + bicuspid AV + Aortic coarctation + HTN

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7
Q

Do men or women have worse outcomes?

A

Women typically have worse outcomes because of delayed diagnosis due to atypical symptoms

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8
Q

What is the DeBakey classification of aortic dissections?

A

Type I = originates in ascending aorta and propagates distally into the descending aorta; Type II = originates in ascending and confined to the ascending only; Type IIIa = originates in the descending thoracic and confined to descending thoracic; Type IIIb = originates in descending and propagates below the diaphragm

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9
Q

What is the SVS/STS classification system for aortic dissections?

A

Based on the location of the intimal tear and the proximal and distal extent of the dissection; Zones 0-12 where Zone 0 is the ascending aorta up to innominate artery, Zone 1 is from innominate to left carotid, Zone 2 is from left carotid to left subclavian, etc.

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10
Q

What is a Type A(d) dissection based on the SVS/STS classification system?

A

The aortic dissection originates in the ascending aorta and goes distally to d (tells us where the distal zone is)

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11
Q

What is a Type B(pd) dissection based on the SVS/STS classification system?

A

The aortic dissection originates from Zone 1 or below (p will tell you where the proximal zone is and d tells you where the distal zone is)

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12
Q

What is a Type I(d) dissection based on the SVS/STS classification system?

A

Indeterminate location for the entry tear and the dissection extends distally to zone d (whatever zone that is)

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13
Q

What should be measured in patients with suspected aortic disease based on 2022 ACC/AHA guidelines?

A

Aortic diameters (longest diameter and its perpendicular diameter at a reproducible anatomic landmark) + root and ascending aortic diameters from edge to edge using ECG synchronized technology

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14
Q

Where should you put your arterial line in type A dissections?

A

Right radial monitors flow to the innominate artery; if axillary cannulation is performed, then left radial artery pressures are needed; sometimes femoral pressures are needed for distal aortic perfusion sensing

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15
Q

What neuromonitoring can you do in Type A dissections?

A

EEG (for deep hypothermic circulatory arrest) + SSEP/MEP + cerebral oximetry

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16
Q

How does hypothermia provide neuroprotection?

A

Decreases global cerebral metabolism of glucose and oxygen + reduces temp-dependent release of glutamate and other excitatory neurotransmitters + inhibits proapoptotic activity + lowers levels of free radicals and inflamatory cytokines

17
Q

How long can you have deep hypothermia (18-19C) for?

A

Up to 40 minutes

18
Q

What are the major complications of deep hypothermic circulatory arrest?

A
  1. Coagulopathy
  2. Post-ischemic hypothermia
  3. Impaired autoregulatory mechanisms
  4. Damage to the blood brain barrier
19
Q

How do you use antegrade cerebral perfusion?

A

Commonly done via axillary or brachiocephalic artery; can also be done selectively (cannula into each head vessel)

20
Q

How do you use retrograde cerebral perfusion?

A

With SVC cannula, blood flows retrograde to the brain