Type 2, 3, and 4 Diseases & Their Antigens

Question 1

AI hemolytic anemia

Answer 1

Rh blood group antigens

I antigen

Question 2

AI thrombocytopenia purpura

Answer 2

Platelet integrin

GP2b:3a

Question 3

Goodpasture’s

Answer 3

basement membrane (Type 4 collagen)

Question 4

Pemphigus vulgaris

Answer 4

Epidermal cadherin

Question 5

Pemphigus follaceus

Answer 5

Desmoglein

Question 6

Acute Rheumatic Fever

Answer 6

Strep cell wall antigens (cross react with cardiac myocytes)

Question 7

Graves

Answer 7

TSHr

Question 8

Myasthenia Gravis

Answer 8

AchR

Question 9

T2DM

Answer 9

Insulin receptor (antagonist)

Question 10

Hypoglycemia

Answer 10

Insulin receptor (agonist)

Question 11

Hypoglycemia

Answer 11

Insulin receptor (agonist)

Question 12

Subacute bacterial endocarditis

Answer 12

bacterial antigen 
(type 3)

Question 13

Mixed essential cryoglobulinemia

Answer 13

Rheumatoid factor IgG complexes (with or without HepC antigens)
(type3)

Question 14

SLE

Answer 14

DNA, histones, ribosomes, snRNP, scRNP

type 3

Question 15

T1DM

Answer 15

Pancreatic Beta-cell antigen

type 4

Question 16

RA

Answer 16

Unknown synovial joint antigen

type 4

Question 17

Multiple Sclerosis

Answer 17

Myelin basic protein, proteolipid protein

type 4