Immunological Diseases Flashcards by Chris Rodarte

Q

DiGeorge

A

Microdeletions in 22q11.2

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Q

RA

A

Rheumatoid factor (IgM or IgG to Fc reigon of IgG)

anti-cyclic citrullinated peptide

Anti-TNF, methotrexate,-hydroxychloroquine

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Q

Hyper IgM

A

CD40L deficiency

Tx = IVIG + antibiotics

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Q

MHC1 deficiency

A

TAP1/2/Tapasin deficiency == No CD8

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Q

CGD

A

NADPH oxidase deficiency

Test - Nitroblue Tetrazolium test

Pyogenic bacteria

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Q

Acute inflammatory polyneuropathy

A

(similar to GBS)

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Q

Poison ivy (contact sensitivity)

A

Th1 cells activate MQ in skin

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Q

Pernicious anemia

A

Anti-intrinsic factor or anti-parietal cells

Test - Anti-Intrinsic Factor ELISA

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Q

GVHD

A

Prevention via stem cells depleted of T cells

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Q

IDDM

A

Type 2 or 4 reaction

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Q

Allergic asthma

A

PEFR test, RAST, ELISA, Total serum IgE

Tx - Epi (short) and glucocorticoids (long)

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Q

SLE

A

Prednisone + Aleve

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Q

Serum sickness

A

Prednisone + antihistamine

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Q

Interferon gamma deficiency

A

susceptible to mycobacteria or intracellular bacteria

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Q

Immune thrombocytopenic purpura

A

Type 2 response to platelet membrane glycoproteins

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Q

Atopic dermatitis

A

Corticosteroid +

Q

Atopic dermatitis

A

Corticosteroid + Tacrolimus + Methotrexate

Q

Hashimotos

A

HLA-DR5 / CTLA4 polymorphism

Q

ADA deficiency

A

SCID

low T and B cells

Q

MHC2 deficiency

A

BLS / SCID

CD4 T cell deficiency

Q

Leukocyte Adhesion Deficiency

A

Beta-2 integrin (CD18) deficiency

(neutrophils)

= Deficient LFA-1 and CR3 (CD11b/CD18)

Q

TSS

A

Polyclonal activation of CD4+ T cells

Q

X linked agammaglobulinemia

A

BTK deficiency

Males more affected

Q

C5-c9 deficiency

Properdin / factor D deficiency

A

Susceptibility to neisseria

Hiv receptor

Cd4 Co receptor = ccr5 and cxcr4