Type 1 Diabetes Flashcards
1
Q
what antigen is important in the pathogenesis of type 1 diabetes?
A
beta cell GAD65
2
Q
pathogenesis of type 1 diabetes
A
autoimmune disease caused by T helper (TH1) cell-recruitment of cytotoxic CD8 cells and destruction of beta cells with cytokines
3
Q
mild symptoms of insulin overdose (hypoglycemia)
A
increased sympathetic tone: sweatiness, tachycardia
4
Q
type 1 diabetes: _____natremia
A
hypo
5
Q
why is diabetic ketoacidosis in type 1 diabetes dangerous?
A
severe hyperglycemia, ketoacidemia, and dehydration may lead to hypovolemic shock
