MEN

Question 1

MEN1 diagnostic criteria (3)

Answer 1

1. clinical: 2 or more MEN1 associated tumors
2. familial: one MEN1 associated tumor + 1st degree relative with MEN1
3. genetic: MEN1 mutation but no clinical/biochemical manifestations of MEN1

Question 2

3 major tumors associated with MEN1; which is most prevalent and presents earliest?

Answer 2

3 P’s: parathyroid (hyperparathyroid), pancreas, pituitary

parathyroid

Question 3

3 major tumors associated with MEN2

Answer 3

medullary thyroid carcinoma (MTC), pheochromocytoma, primary hyperparathyroidism

Question 4

which MEN is associated with RET mutations?

Answer 4

MEN2