Type 1- 2 Flashcards
What mast cells location has the following:
-histamine
-heparin
-lifespan >6mo
Connective tissue and skin
What mast cells location has the following:
-chondroitin sulfate
-few histamine
-lifespan <40 days
Intestine and lungs
Mast cells cause inflammation in?
Seconds
In seconds:
_______ exocytosis
-histamine
-serotonin
Granule
In minutes=
_________ synthesis and secretion
-leukotrienes
-platelet-activating factor
Eicosanoid
In hours:
_________ synthesis and secretion
-IL-4, 5, 6, 13
-TNF-alpha
Cytokine
What are the chemical mediators that are produced after hours?
Cytokines and IL’s
What are the chemical mediators that are produced after mins?
IL and platelet activators
What are the chemical mediators that are produced after seconds?
Histamine and serotonin
IL-___ stimulates production of inflammatory cytokines and chemokines
33
What IL is the MAJOR mediator of type 1?
IL-33
When allergens bind to IgE attached to mast cells —> mast cells release granules and begin to synthesize other factors —> have effects on: GI, _________, and blood vessels
Airways
Mast cell degranulation _________:
Stimulation of alpha adrenoreceptors
Block beta adrenoreceptors
Enhances
Enhancement of mast cell degranulation=
1) ________ inflammation (10-20mins)
2) late phase reaction = 6-12 hours
Immediate
Mast cell degranulation __________:
Block alpha
Stimulate beta
Inhibition
Basophil binds to IgE —> basophils degranulation —> ________ vascular permeability
Increases
What type of cells is the following:
-Long term allergic state
-Initiate helminth response
-protective role in helminths
Basophils
What type of cells:
-Parasites, pathogens, PAMPS and DAMPS
-Leads to production of:
Oxidants and enzymes, lipid mediators, cationic granule proteins, cytokines, and chemokines
Eosinophils
What is the main organ affected in dogs by type 1?
Liver
Tx of Type 1:
-Beta stimulates = epinephrine
-CADI is a allergen specific immunotherapy that targets and neuteralizes canine IL-___
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