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Immno Past Exam 3 > Type 1- 2 > Flashcards

Type 1- 2 Flashcards

1
Q

What mast cells location has the following:
-histamine
-heparin
-lifespan >6mo

A

Connective tissue and skin

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2
Q

What mast cells location has the following:
-chondroitin sulfate
-few histamine
-lifespan <40 days

A

Intestine and lungs

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3
Q

Mast cells cause inflammation in?

A

Seconds

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4
Q

In seconds:
_______ exocytosis
-histamine
-serotonin

A

Granule

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5
Q

In minutes=
_________ synthesis and secretion
-leukotrienes
-platelet-activating factor

A

Eicosanoid

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6
Q

In hours:
_________ synthesis and secretion
-IL-4, 5, 6, 13
-TNF-alpha

A

Cytokine

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7
Q

What are the chemical mediators that are produced after hours?

A

Cytokines and IL’s

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8
Q

What are the chemical mediators that are produced after mins?

A

IL and platelet activators

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9
Q

What are the chemical mediators that are produced after seconds?

A

Histamine and serotonin

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10
Q

IL-___ stimulates production of inflammatory cytokines and chemokines

A

33

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11
Q

What IL is the MAJOR mediator of type 1?

A

IL-33

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12
Q

When allergens bind to IgE attached to mast cells —> mast cells release granules and begin to synthesize other factors —> have effects on: GI, _________, and blood vessels

A

Airways

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13
Q

Mast cell degranulation _________:
Stimulation of alpha adrenoreceptors
Block beta adrenoreceptors

A

Enhances

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14
Q

Enhancement of mast cell degranulation=
1) ________ inflammation (10-20mins)
2) late phase reaction = 6-12 hours

A

Immediate

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15
Q

Mast cell degranulation __________:
Block alpha
Stimulate beta

A

Inhibition

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16
Q

Basophil binds to IgE —> basophils degranulation —> ________ vascular permeability

A

Increases

17
Q

What type of cells is the following:
-Long term allergic state
-Initiate helminth response
-protective role in helminths

A

Basophils

18
Q

What type of cells:
-Parasites, pathogens, PAMPS and DAMPS
-Leads to production of:
Oxidants and enzymes, lipid mediators, cationic granule proteins, cytokines, and chemokines

A

Eosinophils

19
Q

What is the main organ affected in dogs by type 1?

A

Liver

20
Q

Tx of Type 1:
-Beta stimulates = epinephrine
-CADI is a allergen specific immunotherapy that targets and neuteralizes canine IL-___

A

31

Immno Past Exam 3 (6 decks)

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