Reg Of Immune Response 2 Flashcards
Central __ cell tolerance:
-VDJ rearrangement, gene conversion, somatic mutation
-Immune _ cells can recognize self antigens (55-75%)
- _ cell suppression at early stages in animal’s development
B
Peripheral _ cell tolerance:
-Absence of co-stimulation
-Repeated exhaustive antigen stimulation
B
Peripheral B cell tolerance:
Repeated exhaustive antigen stimulation = short lived plasma cells, no memory cells = ________
Tolerance
Oral proteins in _____ doses induces clonal deletion and anergy
High
Oral proteins in ____ doses induces development of T reg cells
Low
Central intolerance of B cells = _______ cell
Peripheral tolerance of B cell = _______ cell —> ______ cell
Immature
Mature
Plasma
What type of immune response may lead to immunodeficiency and increases susceptibility to infection?
Inadequate (low) immune response
What type of immune response may result of allergies or autoimmunity?
Excessive (high) immune response
Antigen increased = immune response is ________
Prolonged
Antigen decreased = immune response ______
Stop
APCs:
Langerhan cells = _ cells
Follicular cells = _ cells
T
B
APCs:
DC1 = Th_
DC2 = Th_
1
2
What controls the immune response:
-Neonatal isoerythrolysis
-Colostrum
-Inhibitory B cell receptor
Immunoglobulins
The presence of maternal antibody in a newborn animal effectively delays the onset Ig synthesis though ________ feedback process
Negative
_____-linkage between a BCR and CD32, an Fc receptors, by antibody and antigen can turn off a B cell by activating a phosphatase that in turn blocks signaling by tyrosine kinase = apoptosis
Cross
