Reg Of Immune Response 2

Question 1

Central __ cell tolerance:
-VDJ rearrangement, gene conversion, somatic mutation
-Immune _ cells can recognize self antigens (55-75%)
- _ cell suppression at early stages in animal’s development

Answer 1

B

Question 2

Peripheral _ cell tolerance:
-Absence of co-stimulation
-Repeated exhaustive antigen stimulation

Answer 2

B

Question 3

Peripheral B cell tolerance:
Repeated exhaustive antigen stimulation = short lived plasma cells, no memory cells = ________

Answer 3

Tolerance

Question 4

Oral proteins in _____ doses induces clonal deletion and anergy

Answer 4

High

Question 5

Oral proteins in ____ doses induces development of T reg cells

Answer 5

Low

Question 6

Central intolerance of B cells = _______ cell
Peripheral tolerance of B cell = _______ cell —> ______ cell

Answer 6

Immature
Mature
Plasma

Question 7

What type of immune response may lead to immunodeficiency and increases susceptibility to infection?

Answer 7

Inadequate (low) immune response

Question 8

What type of immune response may result of allergies or autoimmunity?

Answer 8

Excessive (high) immune response

Question 9

Antigen increased = immune response is ________

Answer 9

Prolonged

Question 10

Antigen decreased = immune response ______

Answer 10

Stop

Question 11

APCs:
Langerhan cells = _ cells
Follicular cells = _ cells

Answer 11

T
B

Question 12

APCs:
DC1 = Th_
DC2 = Th_

Answer 12

1
2

Question 13

What controls the immune response:
-Neonatal isoerythrolysis
-Colostrum
-Inhibitory B cell receptor

Answer 13

Immunoglobulins

Question 14

The presence of maternal antibody in a newborn animal effectively delays the onset Ig synthesis though ________ feedback process

Answer 14

Negative

Question 15

_____-linkage between a BCR and CD32, an Fc receptors, by antibody and antigen can turn off a B cell by activating a phosphatase that in turn blocks signaling by tyrosine kinase = apoptosis

Answer 15

Cross

Question 16

IgG = suppresses production of Ig_/_

Answer 16

G/M

Question 17

IgM suppresses the production of Ig_

Answer 17

M

Question 18

T reg cells:
Natural = _______
Induced = ________
Oral Antigen = _Treg

Answer 18

Thymus
Intestine
I (induced)

Question 19

_reg cells supress Th and CD8 cell activity and

Answer 19

T

Question 20

What is TGF-beta and IL10, 35 produced by?

Answer 20

T reg cells

Question 21

Regulatory T cells are generated by the combined action of IL-2 and TGF-beta, as well of the presence of _______ acid

Answer 21

Retinoic

Question 22

What does indoleamine 2,3 Dioxygenase degrade?

Answer 22

Tryptophan

Question 23

How do encephalins and B endorphin affect T cytotoxic levels?

Answer 23

Increase

Question 24

How does beta endorphin affect antibody production?
How do alpha endorphins affect antibody production?

Answer 24

Increases
Decreases

Question 25

Somatostain ________ immune response Somatotropin _________ immune response

Answer 25

Decreases Increases